A5101400231- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Nanoplatforms for cancer theranostics
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Diabetic Foot Ulcer Assessment and Management
- Bone health and treatments
- Advanced Sensor and Energy Harvesting Materials
- Luminescence and Fluorescent Materials
- Bone and Dental Protein Studies
- Periodontal Regeneration and Treatments
- Advanced biosensing and bioanalysis techniques
- Dental Implant Techniques and Outcomes
- Graphene and Nanomaterials Applications
- Orthopedic Infections and Treatments
- Pressure Ulcer Prevention and Management
- Additive Manufacturing and 3D Printing Technologies
- Conducting polymers and applications
- Advanced Nanomaterials in Catalysis
- Anatomy and Medical Technology
- Hydrogels: synthesis, properties, applications
XinHua Hospital
2023-2025
Shanghai Jiao Tong University
2020-2025
Second Affiliated Hospital of Jilin University
2018-2025
Xinjiang University
2025
New York University Shanghai
2024
Shanghai University
2024
Dalian University
2024
Dalian University of Technology
2024
Hunan University
2019-2023
Renji Hospital
2020-2022
Abstract Recently, artificial intelligence research has driven the development of stretchable and flexible electronic systems. Conductive hydrogels are a class soft materials that have emerging applications in wearable implantable biomedical devices. However, current conductive possess fundamental limitations terms their antibacterial performance mechanical mismatch with human tissues, which severely limits biological interfaces. Here, inspired by animal skin, hydrogel is fabricated from...
Stem cell-based therapy has drawn attention for enhancing the osseointegration efficiency after joint replacement in rheumatoid arthritis (RA). However, therapeutic efficacy of this approach is threatened by accumulated reactive oxygen species (ROS) and poor supply. Herein, we develop a nanozyme-reinforced hydrogel reshaping hostile RA microenvironment improving prosthetic interface osseointegration. The engineered not only scavenges endogenously over-expressed ROS, but also synergistically...
Abstract Non‐healing wound is a common complication of diabetic patients associated with high morbidity and mortality. Engineered therapeutic hydrogels have enviable advantages in tissue regeneration, however, they are suboptimal for the healing wounds characterized by reactive oxygen species (ROS) accumulation chronic hypoxia. Here, unique biological metabolism‐inspired hydrogel, ameliorating this hostile microenvironment, presented. Consisting natural polymers (hydrazide modified...
Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels are promising systems for DFU-based wound management, their effectiveness is often hindered by the immune response and hostile microenvironment associated with uncontrollable accumulation of reactive oxygen species hypoxia. Here, we develop therapeutic dressing using biomimetic hydrogel system decoration catalase-mimic nanozyme, namely, MnCoO@PDA/CPH. The can be designed match mechanical electrical cues...
Osteoarthritis (OA) is a common joint disease known for cartilage degeneration, leading to substantial burden on individuals and society due its high disability rate. However, current clinical treatments defects remain unsatisfactory the unclear mechanisms underlying regeneration. Tissue engineering hydrogels have emerged as an attractive approach in repair. Recent research studies indicated that stem cells can sense mechanical strength of hydrogels, thereby regulating their differentiation...
Traditional hydrogel design and optimization methods usually rely on repeated experiments, which is time-consuming expensive, resulting in a slow-moving of advanced development. With the rapid development artificial intelligence (AI) technology increasing material data, AI-energized hydrogels for biomedical applications has emerged as revolutionary breakthrough materials science. This review begins by outlining history AI potential advantages using hydrogels, such prediction properties,...
A diabetic foot ulcer (DFUs) is a state of prolonged chronic inflammation, which can result in amputation. Different from normal skin wounds, various commercially available dressings have not sufficiently improved the healing DFUs. In this study, novel self-healing hydrogel was prepared by situ crosslinking N-carboxyethyl chitosan ( N-chitosan) and adipic acid dihydrazide (ADH) with hyaluronic acid-aldehyde (HA-ALD), to provide moist inflammatory relief environment promote stem cell...
The healing of diabetic foot ulcers (DFUs) is a major challenge for clinical treatment because the hyperglycemic and acidic microenvironment in wound area. In this study, self-healing, injectable, pH-responsive hydrogel was synthesized by N-carboxyethyl chitosan (N-chitosan), hyaluronic acid–aldehyde (HA-ALD), adipic acid dihydrazide (ADH) through formation reversible dynamic bonds, acylhydrazone imine bonds. presence bond characterizes property. insulin glargine successfully incorporated...
Diabetic foot ulcers (DFUs) are hard-healing chronic wounds and susceptible to bacterial infection. Conventional hydrogel dressings easily lose water at high temperature or freeze low temperature, making them unsuitable for long-term use in extreme environments. Herein, a temperature-tolerant (−20 60 °C) antibacterial dressing is fabricated by the assembly of polyacrylamide, gelatin, ε-polylysine. Owing water/glycerin (Gly) binary solvent system, resultant (G-PAGL) displayed good heat...
: Osteoporosis is more likely to cause serious complications after joint replacement, mainly due physiological defects of endogenous osteogenic cells and the pathological osteoclast activity. It a feasible solution design prosthetic surface interface that specifically addresses this troublesome situation.
3D printed porous titanium alloy implants is an advanced orthopedic material for joint replacement. However, the high risk of aseptic loosening and periprosthetic infection difficult to avoid, declined autophagy osteoporosis-derived bone marrow mesenchymal stem cells (OP-BMSCs) further severely impairs osseointegration under osteoporotic circumstance. It thus becoming urgently significant develop materials with regulation antibacterial bioactivity. In this regard, a novel class...
Patients with osteoporosis are more likely to suffer prosthesis displacement, subsidence or periprosthesis fracture after replacement. This is due excessive osteoclast activity and a lack of bone marrow mesenchymal stem cell (BMSC) integration at the implant-bone interface locally in setting osteoporosis. In order inhibit local resorption promote integration, we have constructed porous titanium/poloxamer 407 hydrogel system loaded zoledronate (ZOL), bisphosphonate, osteointegration rabbit...
Abstract Stem cell transplantation is a promising alternative therapy for rheumatoid arthritis (RA) patients, with the potential to suppress autoimmune inflammation and prevent joint damage. However, widespread application of RA based on stem limited due poor migration, local retention, uncontrolled differentiation cells. Here, inspired by dynamic construction bone matrix, structurally functionally optimized scaffold loading marrow cells (BMSCs) designed aid management. The composite...
Biomaterial with the dual-functions of bone regeneration and antibacterial is a novel therapy for infective defects. Three-dimensional (3D)-printed porous titanium (pTi) benefits ingrowth, but its microporous structure conducive to bacteria reproduction. Herein, multifunctional hydrogel was prepared from dynamic supramolecular assembly sodium tetraborate (Na 2 B 4 O 7 ), polyvinyl alcohol (PVA), silver nanoparticles (AgNPs) tetraethyl orthosilicate (TEOS), composited pTi as an implant...
Intra-articular injection of mesenchymal stem cells is a potential therapeutic strategy for cartilage protection and symptom relief osteoarthritis (OA). However, controlling chondrogenesis the implanted in articular cavity remains challenge. In this study, hydrogels containing different concentrations icariin were prepared by situ crosslinking hyaluronic acid Poloxamer 407. This injectable thermoresponsive hydrogel, as 3D cell culture system, showed good biocompatibility with chondrocytes...