A5091170889- Privacy-Preserving Technologies in Data
- Wireless Communication Networks Research
- Drug Transport and Resistance Mechanisms
- Advanced Wireless Communication Techniques
- Signaling Pathways in Disease
- Advanced MIMO Systems Optimization
- Lipid Membrane Structure and Behavior
- Speech and Audio Processing
- Error Correcting Code Techniques
- Metabolism and Genetic Disorders
- Cellular transport and secretion
- Cognitive Radio Networks and Spectrum Sensing
- Amino Acid Enzymes and Metabolism
- Interconnection Networks and Systems
- Cryptography and Data Security
- Image Processing Techniques and Applications
- Advanced Data Storage Technologies
- Image and Signal Denoising Methods
- Cellular Automata and Applications
- Blind Source Separation Techniques
- Speech Recognition and Synthesis
- Vehicular Ad Hoc Networks (VANETs)
- Privacy, Security, and Data Protection
- IoT and Edge/Fog Computing
- Ethics in Clinical Research
Xuzhou Medical College
2014-2025
Zhejiang A & F University
2024-2025
University of Malaya
2022-2024
Shanghai University
2024
Sun Yat-sen University
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
KU Leuven
2024
University of Gothenburg
2024
China University of Geosciences (Beijing)
2024
Changsha University of Science and Technology
2023
We have isolated a cDNA from rat placenta which, when expressed heterologously, mediates the transport of wide spectrum organic cations. The codes for protein 551 amino acids containing 12 putative transmembrane domains. Northern blot analysis indicates that this transporter is most abundantly in and moderately intestine, heart, brain. expression comparatively low kidney lung undetectable liver. This distinct previously cloned cation transporters (OCT1, OCT2, NKT, NLT, RST, OCTN1). When HeLa...
Segmental bone defects, stemming from trauma, infection, and tumors, pose formidable clinical challenges. Traditional repair materials, such as autologous allogeneic grafts, grapple with limitations including source scarcity immune rejection risks. The advent of nucleic acid nanotechnology, particularly the use DNA hydrogels in tissue engineering, presents a promising solution, attributed to their biocompatibility, biodegradability, programmability. However, these hydrogels, typically...
We investigated the transport of cationic neurotoxins and neurotransmitters by potential-sensitive organic transporter OCT3 its steroid sensitivity using heterologous expression systems also analyzed in brain. When expressed mammalian cells, mediates uptake neurotoxin 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>) neurotransmitter dopamine. Competition experiments show that several neuroactive agents including amphetamines interact with OCT3. <i>Xenopus laevis</i> oocytes, OCT3-mediated...
We have demonstrated in the present study that novel organic cation transporter (OCTN) 2 is a for cations as well carnitine. OCTN2 transports without involving Na(+), but it carnitine only presence of Na(+). The ability to transport and demonstrable with human, rat, mouse OCTN2s. Na(+) does not influence affinity cations, increases severalfold short-chain acyl esters are also transported by OCTN2. Two mutations, M352R P478L, human associated loss function, protein expression these mutants...
Epistasis Detection (ED) was widely used for identifying potential risk disease variants in the human genome. A statistically meaningful ED typically requires a more extensive dataset to detect complex disease-associated Single Nucleotide Polymorphisms (SNPs), but single institution generally possesses limited genome data. Thus, it is necessary collect multi-institutional data carry out research together. However, concerns regarding privacy and trustworthiness impede sharing of massive...
Abusing antibiotic residues in the natural environment has become a severe public health and ecological environmental problem. The side effects of its biochemical physiological consequences are severe. To avoid contamination water, implementing universal rapid residue detection technology is critical to maintaining safety aquatic environments. Surface-enhanced Raman spectroscopy (SERS) provides powerful tool for identifying small molecular components with high sensitivity selectivity....
We examined in this study the expression of potential-sensitive organic cation transporter OCT3 kidney. A functionally active was cloned from a mouse kidney cDNA library. The found to be capable mediating potential-dependent transport variety cations including tetraethylammonium. This function confirmed two different heterologous systems involving mammalian cells and Xenopus laevis oocytes. have also isolated gene deduced its structure organization. consists 11 exons 10 introns. In situ...
Systemic primary carnitine deficiency (CDSP, OMIM 212140) is an autosomal recessive disease characterized by low serum and intracellular concentrations of carnitine. CDSP may present with acute metabolic derangement simulating Reye's syndrome within the first 2 years life. After 3 age, patients cardiomyopathy muscle weakness. A linkage D5S436 in 5q was reported a family. recently cloned homologue organic cation transporter, OCTN2, which has sodium-dependent uptake properties, also mapped to...
Objective Deep learning algorithms have long been involved in the diagnosis of severe neurological disorders that interfere with patients’ everyday tasks, such as Parkinson’s disease (PD). The most effective imaging modality for detecting condition is DaTscan, a variety single-photon emission computerized tomography (SPECT) method. goal to create convolutional neural network can specifically identify region interest following feature extraction. Methods study comprised total 1,390 DaTscan...
Background Breast cancer remains a pressing global health concern, necessitating accurate diagnostics for effective interventions. Deep learning models (AlexNet, ResNet-50, VGG16, GoogLeNet) show remarkable microcalcification identification (>90%). However, distinct architectures and methodologies pose challenges. We propose an ensemble model, merging unique perspectives, enhancing precision, understanding critical factors breast intervention. Evaluation favors GoogleNet driving their...
Generative AI has become the focus of intelligent education field, especially in generation personalized learning resources. Current resource methods recommend customized courses based on styles and interests, improving efficiency. However, these cannot generate tutorials according to learners' preferences, nor can they adjust tutorial content as moods or levels knowledge change. Therefore, this study develops an tutorial-generating system (Self-GT) for self-aid learning, integrating...
Background Maintaining machines effectively continues to be a challenge for industrial organisations, which frequently employ reactive or premeditated methods. Recent research has begun shift its attention towards the application of Predictive Maintenance (PdM) and Digital Twins (DT) principles in order improve maintenance processes. PdM technologies have capacity significantly profitability, safety, sustainability various industries. Significantly, precise equipment estimation, enabled by...
Novel organic cation transporter (OCTN2) is an cation/carnitine transporter, and two missense mutations, L352R P478L, in OCTN2 have been identified as the cause for primary carnitine deficiency. In present study, we assessed influence of these mutations on transport function OCTN2. The mutation resulted a complete loss both functions. contrast, P478L only but significantly stimulated function. Studies with human OCTN2/rat chimeric transporters indicated that site were not identical. Because...
Abstract Energy storage compounds play crucial roles in prokaryotic physiology. Five chemical have been identified prokaryotes as energy reserves: polyphosphate (polyP), polyhydroxyalkanoates (PHAs), glycogen, wax ester (WE) and triacylglycerol (TAG). Currently, no systematic study of archaeal metabolism exists. In this study, we collected 427 reference sequences from UniProt database. A thorough pathway screening reserves led to an overview distribution patterns archaea. We also explored...
The importance of strategies and services by caregivers family members substantially impact the psychological emotional wellbeing autistic children. rapid research developments in clinical non-clinical methods benefit features Among various internal external factors, influence built environment also impacts characteristics This study investigates primarily effect light colors on mood behavior children to identify most favorable preferred indoor lights color shades.
Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less inclusion bodies (IBs). Here, using a yeast imaging-based screen, we identified 84 potential synphilin-1 (SY1) IB regulators isolated the conserved sphingolipid metabolic components in most enriched groups. Furthermore, show that, both cells mammalian cells, SY1 IBs are associated with mitochondria. Pharmacological inhibition metabolism...