A5101668001- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Nanoparticle-Based Drug Delivery
- Plant Reproductive Biology
- Circular RNAs in diseases
- Mesoporous Materials and Catalysis
- Polyoxometalates: Synthesis and Applications
- RNA Research and Splicing
- Plant Molecular Biology Research
- Plant Surface Properties and Treatments
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Polymer Surface Interaction Studies
- Postharvest Quality and Shelf Life Management
- Plant tissue culture and regeneration
- Seed Germination and Physiology
- Plant Stress Responses and Tolerance
- Transition Metal Oxide Nanomaterials
- Soybean genetics and cultivation
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Nanomaterials in Catalysis
- Chemical Synthesis and Analysis
- Plant Pathogenic Bacteria Studies
XinHua Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
Beijing Forestry University
2021-2024
State Key Laboratory of Tree Genetics and Breeding
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Dezhou University
2023
King Abdullah University of Science and Technology
2011-2015
Zhengzhou University of Light Industry
2013
Tongji University
2010-2012
Purdue University West Lafayette
2011
Abstract Mutation of the ECERIFERUM9 (CER9) gene in Arabidopsis (Arabidopsis thaliana) causes elevated amounts 18-carbon-length cutin monomers and a dramatic shift cuticular wax profile (especially on leaves) toward very-long-chain free fatty acids tetracosanoic acid (C24) hexacosanoic (C26). Relative to wild type, cer9 mutants exhibit cuticle membrane thickness over epidermal cells ledges with increased occlusion stomatal pore. The phenotypes are associated delayed onset wilting plants...
Abstract The plant cuticle, a structure primarily composed of wax and cutin, forms continuous coating over most aerial surfaces. cuticle plays important roles in tolerance to environmental stress, including stress imposed by drought. Some members the 3-KETOACYL-COA SYNTHASE (KCS) family are known act as metabolic enzymes involved cuticular production. Here we report that Arabidopsis (Arabidopsis thaliana) KCS3, which was previously shown lack canonical catalytic activity, instead functions...
LATERAL ORGAN BOUNDARIES DOMAIN 29 (LBD29), an important molecule downstream of auxin response factors ARF7 and ARF19, has a critical role in lateral root formation Arabidopsis thaliana. The cell cycle activation pericycle cells their specification triggered by are crucial for the initiation roots. In this study, we attempted to determine whether LBD29 is involved signalling and/or regulation characterize roles these processes. impact on cycling progression was investigated lbd29...
Abstract Lymph node metastasis is one of the most malignant clinical features in patients with esophageal squamous cell carcinoma (ESCC). Understanding mechanism lymph will provide treatment strategies for ESCC. Long noncoding RNAs (lncRNA) play a critical role development and progression human cancers. However, lncRNAs remain largely unknown. Here we show that VEGFC mRNA stability–associated long RNA (VESTAR) involved VESTAR was overexpressed ESCC tissues predictive poor prognosis In ESCC,...
Infected wounds pose a significant clinical challenge due to bacterial resistance, recurrent infections, and impaired healing. Reactive oxygen species (ROS)-based strategies have shown promise in eradicating infections. However, the excess ROS infection site after treatments may cause irreversible damage healthy tissues. To address this issue, we developed bovine serum albumin-iridium oxide nanoclusters (BSA-IrO
A novel mutant of Arabidopsis (Arabidopsis thaliana), having highly glossy inflorescence stems, postgenital fusion in floral organs, and reduced fertility, was isolated from an ethyl methanesulfonate-mutagenized population designated glossyhead1 (gsd1). The gsd1 locus mapped to chromosome 1, the causal gene identified as a new allele Acetyl-Coenzyme Carboxylase1 (ACC1), encoding main enzyme cytosolic malonyl-coenzyme synthesis. This, our knowledge, is first ACC1 that does not cause lethality...
The inner structure of W18O49 mesocrystals was observed by electron microscopy with the help ultramicrotomy and focused ion beam techniques. results showed that these contain irregular mesopores formed through partial fusion self-assembled nanowires, consequently have long-range structural ordering in one dimension short-range other two dimensions. exhibit superior performance gas sensing applications, which is considered to be associated presence more oxygen vacancy sites unique mesoporous...
Abstract Cachexia, characterized by loss of skeletal muscle mass and function, is estimated to inflict the majority patients with oesophageal squamous cell carcinoma (ESCC) associated their poor prognosis. However, its underlying mechanisms remain elusive. Here, we developed an ESCC‐induced cachexia mouse model using human xenograft ESCC lines found that ESCC‐derived extracellular vesicles (EVs) containing prolyl 4‐hydroxylase subunit beta (P4HB) induced apoptosis cells. We further...
Abstract Bone organoids, in vitro models mimicking native bone structure and function, rely on 3D stem cell culture for self‐organization, differentiation, ECM secretion, biomineralization, ultimately forming mineralized collagen hierarchies. However, their development is often limited by the lack of suitable matrices with optimal mechanical properties sustained growth differentiation. To address this, a dynamic DNA/Gelatin methacryloyl (GelMA) hydrogel (CGDE) developed to recapitulate key...
The innovative HaloTag is a labeling technology that plays crucial role in advanced fluorescence imaging. However, due to the complexity of plant materials, application field plants still its infancy. To expand cells, we constructed six eukaryotic gene expression vectors with different localizations carrying labels, then transformed Arabidopsis thaliana and Nicotiana benthamiana, finally stained living cells using ligands. Live-cell imaging showed did not affect localization pattern...
The ECERIFERUM9 (CER9) gene encodes a putative E3 ubiquitin ligase that functions in cuticle biosynthesis and the maintenance of plant water status. Here, we found CER9 is also involved abscisic acid (ABA) signaling seeds young seedlings Arabidopsis (Arabidopsis thaliana). germinated embryos mutants exhibited enhanced sensitivity to ABA during transition from reversible dormancy determinate seedling growth. Expression closely related levels displays similar pattern ABSCISIC ACID-INSENSITIVE5...
Abstract Ginkgo (Ginkgo biloba L.) is one of the earliest extant species in seed plant phylogeny. Embryo development patterns can provide fundamental evidence for origin, evolution, and adaptation seeds. However, architectural morphological dynamics during embryogenesis G. remain elusive. Herein, we obtained over 2,200 visual slices from 3 stages embryo using micro-computed tomography imaging with improved staining methods. Based on 3-dimensional (3D) spatiotemporal pattern analysis, found...
Tumor targetability and stimuli responsivity of drug delivery systems (DDS) are key factors in cancer therapy. Implementation multifunctional DDS can afford at the same time. Herein, cholesterol molecules (Ch) were coupled to hyaluronic acid (HA) backbones amphiphilic conjugates that self-assemble into stable micelles. Doxorubicin (DOX), an anticancer drug, superparamagnetic iron oxide (SPIO) nanoparticles (NPs), magnetic resonance imaging (MRI) contrast agents, encapsulated by Ch–HA...
Osteoarthritis (OA) is a common degenerative disease with high disability rate, imposing significant economic burdens on individuals and society. Due to the limited self-repair ability of articular cartilage, existing treatment methods still cannot effectively treat OA. Organoids are multicellular structures differentiated from stem cells or organ progenitors can be used model disease. Future applications provide alternative replacement strategies. Therefore, constructing cartilage organoids...
Abstract The geometric shape and arrangement of individual cells play a role in shaping organ functions. However, analyzing multicellular features exploring their connectomes centimeter-scale plant organs remain challenging. Here, we established set frameworks named large-volume fully automated cell reconstruction (LVACR), enabling the exploration 3D cytological cellular connectivity tissues. Through benchmark testing, our framework demonstrated superior efficiency segmentation aggregation,...
Controlled synthesis of mesoporous materials with ultracomplicated pore configurations is great importance for both fundamental research nanostructures and the development novel applications. IBN-9, which only tricontinuous silica three sets interpenetrating three-dimensional channel systems, appears to be an excellent model mesophase such study. The extensive study space diagrams proves transition among cylindrical MCM-41, IBN-9 bicontinuous MCM-48, also allows a more precise control...
The circularly permuted GTPase large subunit 1 (LSG1) is involved in the maturation step of 60S ribosome and essential for cell viability yeast. Here, an Arabidopsis mutant dig6 (drought inhibited growth lateral roots) was isolated. exhibited multiple auxin-related phenotypes, which included reduced root number, altered leaf veins, shorter roots. Genetic mapping combined with next-generation DNA sequencing identified that mutation occurred AtLSG1-2. This gene highly expressed regions auxin...
Multifunctional magnetic microcapsules (MMCs) for the combined cancer cells hyperthermia and chemotherapy in addition to MR imaging are successfully developed. A classical layer‐by‐layer technique of oppositely charged polyelectrolytes (poly(allylamine hydrochloride) (PAH) poly(4‐styrene sulfonate sodium) (PSS)) is used as it affords great controllability over preparation together with enhanced loading chemotherapeutic drug (doxorubicin, DOX) microcapsules. Superparamagnetic iron oxide...
IBN-9 is the first tricontinuous mesoporous material, consisting of three identical interpenetrating channels that are separated by a single continuous silica wall. It was originally synthesized using specially designed surfactant as template. The need special in synthesis inhibits extensive investigation this novel structure and its applications. We demonstrate study such complicated mesostructure can also be fabricated from most common commercially available cetyltrimethylammonium bromide...