A5066450002- Breast Cancer Treatment Studies
- Parathyroid Disorders and Treatments
- Breast Implant and Reconstruction
- Thyroid Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Breast Lesions and Carcinomas
- Thyroid and Parathyroid Surgery
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
- Genetic Syndromes and Imprinting
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Global Cancer Incidence and Screening
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Cancer Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Pituitary Gland Disorders and Treatments
- Medical Imaging and Pathology Studies
University of Iowa
2016-2025
University of Iowa Hospitals and Clinics
2012-2023
New York Proton Center
2022
University of California, Irvine
2022
Icahn School of Medicine at Mount Sinai
2022
City of Hope
2022
University of Iowa Health Care
2022
University of Iowa Holden Comprehensive Cancer Center
2019
The University of Tokyo
2013
Iowa City Public Library
2010
Rearrangements involving the RET protooncogene have been implicated in development of papillary thyroid carcinoma (PC). Transgenic mice, expressing thyroid-targeted RET/PTC-1, develop PC; but clinical significance this oncogene remains uncertain. We examined expression -2, and -3 human microcarcinomas clinically evident PC to determine its role early stage vs. developed examine diversity RET/PTC multifocal disease. RNA was extracted from paraffin-embedded PCs; results obtained tissue were...
Here we report that miR-93, a miRNA in the miR-106B~25 cluster, paralog of miR-17-92 was significantly upregulated human breast carcinoma tissues. We stably expressed miR-93 MT-1 cell line and found tumors formed by cells contained more blood vessels than those control cells. Co-culture experiments indicated displayed high activity adhesion with endothelial could form larger tube-like structures Lung metastasis assays were performed mouse metastatic model, it expression promoted tumor to...
MicroRNAs are known to play regulatory roles in gene expression associated with cancer development. We analyzed microRNA miR-24 levels patients breast carcinoma and found that was higher samples than benign tissues. generated constructs expressing studied its functions using both vitro vivo techniques. the ectopic of promoted cell invasion migration. In experiments indicated enhanced tumor growth, local tissues, metastasis lung decreased overall mouse survival. cells tumors, EGFR highly...
Abstract As geographical location can impact the gut microbiome, it is important to study region-specific microbiome signatures of various diseases. Therefore, we profiled breast cancer (BC) patients Midwestern region United States. The bacterial component was utilizing 16S ribosomal RNA sequencing. Additionally, a gene pathway analysis performed assess functional capabilities microbiome. Alpha diversity not significantly different between BC and healthy controls (HC), however beta revealed...
This study determined, prospectively, whether duodenotomy (DX) should be routinely performed in explorations for patients with Zollinger-Ellison syndrome (ZES).Duodenal gastrinomas are now being found increasing frequency syndrome. The surgical approach used to detect these tumors is controversial. Some recommend intraoperative endoscopy transillumination (IOE) at surgery, while others routine DX.Beginning 1989, the authors prospectively compared ability of palpation, ultrasound (IOUS), IOE,...
The ret/PTC oncogene is unique to papillary thyroid cancer. Three forms of this oncogene, formed by translocation three different genes the tyrosine kinase domain ret protooncogene, result in constitutive activation. Correlation with clinical outcome controversial; ret/PTC-1 has been suggested predict aggressive behavior. There no morphological description ret/PTC-positive tumors. We analyzed 60 carcinomas for expression determine correlation history, disease stage, or tumor morphology....
We sought to establish the clinical relevance of micrometastatic disease detected by reverse transcription polymerase chain reaction (RT-PCR) in axillary lymph nodes (ALN) breast cancer patients.The presence ALN metastases remains one most valuable prognostic indicators women with cancer. However, molecular detection sentinel (SLN) and nonsentinel has not been established.Four hundred eighty-nine patients T1-T3 primary cancers were analyzed a prospective, multi-institutional cohort study....
Abstract Phosphatidylserine (PS), which is exposed on the surface of apoptotic cells, has been implicated in immune regulation. However, effects PS maturation and function dendritic cells (DCs), play a central role both activation regulation, have not described. Large unilamellar liposomes containing or phosphatidylcholine were used to model plasma membrane phospholipid composition live respectively. inhibited up-regulation HLA-ABC, HLA-DR, CD80, CD86, CD40, CD83, as well production IL-12p70...
Chronic upper extremity disability (UED) is common after breast cancer treatment but under-identified and under-treated. Although UED has been linked to quality of life (QoL), the role as mediator between contemporary practices QoL not quantified. This investigation describes in a sample patients examines its relationship with personal factors QoL.Eight hundred thirty-three women diagnosed at eight medical institutions during 2013-2014 microscopically confirmed ductal carcinoma situ or...
Abstract Background Breast cancer is the most common in women diagnosed U.S. and worldwide. Obesity increases breast risk without clear underlying molecular mechanisms. Our studies demonstrate that circulating adipose fatty acid binding protein (A-FABP, or FABP4) links obesity-induced dysregulated lipid metabolism risk, thus potentially offering a new target for treatment. Methods We immunized FABP4 knockout mice with recombinant human screened hybridoma clones specific to FABP4. The...
The incidence of breast cancer continues to rise each year despite significant advances in diagnosis and treatment. Obesity-associated dysregulated lipid metabolism is believed contribute the increasing risk cancer. However, mechanisms linking dysregulation progression remain be determined. family fatty acid binding proteins (FABPs) evolves facilitate transport metabolism. As predominant isoforms FABP members expressed tissue, adipose (A-FABP, also known as FABP4) epithelial (E-FABP, FABP5)...
Estrogen-nonresponsive estrogen receptor-α (ERα) knock-in (ENERKI) mice were generated to distinguish between ligand-induced and ligand-independent ER-α actions in vivo. These have a mutation [glycine 525 leucine (G525L)] the ligand-binding domain of ERα, which significantly reduces ERα interaction with response endogenous estrogens, whereas not affecting growth factor activation pathways. ENERKI had hypoplastic uterine tissues rudimentary mammary gland ductal trees. Females infertile due...
Recent findings suggest that combination treatment with antiestrogen and anti-RET may offer a novel strategy in subset of patients breast cancer. We investigated the role RET potentiating effects response examined whether expression predicted ability for tyrosine kinase inhibitor (TKI) to affect extracellular signal-regulated 1/2 (ERK1/2) activation primary cancer.Growth response, ERK1/2 activation, Ki-67, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling were assessed...