A5101514324- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Breast Cancer Treatment Studies
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Sepsis Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Global Cancer Incidence and Screening
- Cardiac Imaging and Diagnostics
- Chronic Kidney Disease and Diabetes
- Wnt/β-catenin signaling in development and cancer
- Renal Diseases and Glomerulopathies
- Hepatitis C virus research
- Medical Imaging Techniques and Applications
First Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Sir Run Run Shaw Hospital
2017-2025
Zhejiang University
2017-2025
Beijing Chaoyang Emergency Medical Center
2024
Xian Yang Central Hospital
2024
Qingdao University
2024
Qingdao Municipal Hospital
2024
Ruijin Hospital
2009-2022
Xi'an Jiaotong University
2013-2015
Huashan Hospital
2015
Abstract Background Tyrosine kinase inhibitors (TKIs) that specifically target mutational points in the EGFR gene have significantly reduced suffering and provided greater relief to patients with lung adenocarcinoma (LUAD). The third-generation EGFR-TKI, Osimertinib, has been successfully employed clinical treatments overcome resistance both original acquired T790M L858R points. Nevertheless, issue of treatment failure response emerged as an insurmountable problem. Methods By employing a...
Abstract Triple‐negative breast cancer ( TNBC ) is the most aggressive subtype with a poor prognosis. The micro RNA ‐200 (miR‐200) family has been associated metastasis. However, epigenetic mechanisms underlying miR‐200b repression in are not fully elucidated. In this study, we found that MYC proto‐oncogene, bHLH transcription factor (MYC) and DNA methyltransferase 3A DNMT 3A) were highly expressed tissues compared other subtypes, while expression was inhibited significantly. We demonstrated...
The E-cadherin gene (CDH1) is associated with poor prognosis and metastasis in patients breast cancer, methylation of its promoter correlated decreased expression. However, there currently no direct evidence that CDH1 indicates cancer. In the present study, methylation-specific polymerase chain reaction (PCR) was applied to detect status 137 primary 85 matched normal tissue 13 lung specimens. Reverse transcription-quantitative PCR used assess relative expression levels mRNA, correlation...
Tamoxifen (TAM) resistance is a substantial challenge in the treatment of estrogen receptor (ER)-positive breast cancer. Previous studies have revealed an important role microRNA (miRNA/miR)-26a TAM However, mechanism underlying regulatory effects miR-26a on remains to be elucidated. The expression levels ER-positive cancer were detected by reverse transcription-quantitative polymerase chain reaction. E2F transcription factor 7 (E2F7) and MYC proto-oncogene, bHLH (MYC) western blotting....
The small tyrosine kinase inhibitors (TKIs) subversively altered the lung cancer treatments, but patients will inevitably face therapy resistance and disease recurrence. We aim to explore potential roles of non-coding RNAs in sensitizing TKIs effects. Multiple cellular molecular detections were applied confirm mechanistic regulations intracellular connections. explored specific gene features candidates association with resistance, found that m6A controlled stemness EMT through METTL3 YTHDF2....
// Xin Sun 1, * , Shiwen Jiang 2, Jian Liu 1 Huangzhen Wang Yiwen Zhang Shou-Ching Tang 3, 4 Jichang 5 Ning Du Chongwen Xu Chenguang 6 Sida Qin Jia Dapeng Yunfeng Xiaojun Li Jiansheng Jun Dong 7 8 Shaohua 9 Zhen Tao 10 Fei 11 Jie Zhou 12 13 Hong Ren Department of Thoracic Surgery and Oncology, the First Affiliated Hospital Xi’an Jiaotong University, Xi’an, Shaanxi Province, 710061, China 2 Obstetrics Gynecology, Second Wenzhou Medical Wenzhou, Zhejiang 325027, 3 Breast Cancer...
Abstract Objectives Breast cancer stem‐like cells (BrCSCs) are the major reason for tumour generation, resistance and recurrence. The turbulence of their self‐renewal ability could help to constrain stem cell expansion. way BrCSCs divided was related capacity, symmetric division contributed a higher ability. Non‐coding long RNA H19 involved in multiple malignant procedures; role mechanistic proof non‐coding controlling divisions were barely known. Materials Methods Indicative functions...
Let-7 miRNAs act as tumour suppressors by directly binding to the 3'UTRs of downstream gene products. The regulatory role let-7 in expression has gained much interest cancer research community, it controls multiple biological functions and determines cell fates. For example, one target family is cyclin D1, which promotes G0/S cycle progression oncogenesis, was correlated with endoribonuclease DICER1, another let-7. Down-regulated been identified many types tumours, suggesting a feedback loop...
The molecular mechanism of the tyrosine kinase inhibitor (TKI) resistant lung adenocarcinoma is currently unclear, and role methylated adenosine at N6 position in resistance cancer stem cells (CSCs) therapy unknown. This study identified a novel effective strategy to enhance TKIs response. We first confirmed sensitization Metformin enforcing on Osimertinib treatment revealed mature miRNAs signatures H1975 HCC827 cells. Let-7b expression was stimulated when adding then increasing sensitivity...
Objective: This research sought to assess the predictive potential of inflammation-immunity-nutrition score (IINS) and high-sensitivity C-reactive protein-albumin-lymphocyte (CALLY) index in individuals with NSCLC post-surgery. Methods: The study enrolled 506 patients undergoing R0 resection at First Affiliated Hospital Xi'an Jiaotong University. training cohort was analyzed utilizing X-tile software identify ideal threshold values for categorizing protein, albumin, lymphocyte count, CALLY...
Objective To compare the image quality, radiation dose, and examination time between non-electrocardiogram (ECG)-gated coronary CT angiography (ECG-less CCTA) conventional ECG-gated CCTA using wide-detector CT, validate its clinical applicability. Methods In this prospective study, 109 patients with suspected artery disease were divided into ECG-less (Group A, n = 59) B, 50) groups. metrics (CT attenuation, noise, SNR, CNR), subjective quality (4-point scale), analyzed. Diagnostic...
Abstract Background Immunotherapy, particularly anti-PD-1 therapy, has assumed a progressively significant position in the management of non-small cell lung cancer (NSCLC), especially adenocarcinoma (LUAD). Nevertheless, subset patients exhibit resistance to and exploration biomarkers for evaluating responsiveness therapy necessitates further investigation. FLT3LG is regarded as being associated with tumor diagnosis immunotherapy variety types, but its function LUAD uncertain. Methods...
Let-7 microRNAs have been reported to tumor suppressive functions; however, the effect of when used in combination with chemotherapies is uncertain, but may potential for use clinical practice. In this study, we RT-qPCR, western blot analysis, cell proliferation assay, flow cytometry immunohistochemistry (IHC) staining, luciferase assays, sorting analysis and xenografted model explore role chemotherapy sensitivity breast cancer stem cells. The findings current study indicated that Let‑7...
Abstract Objective The aim of this study was to assess the diagnostic value PET/CT for metastatic lymph nodes in cervical cancer patients. Methods Searching databases including PubMed, Embase, Web Science, Cochrane Library and Google Scholar about non-invasive modalities detecting metastases during 2000~2017. Following further screening, extracted effective data were calculated by Meta-Disc 1.4 software, such as sensitivity (SEN), specificity (SPE), positive likelihood (LR+), negative ratio...
Abstract Matrine, a natural product extracted from the root of Sophora flavescens Ait, was main chemical ingredient compounds Kushen injection, which has been widely used for its remarkable anticancer effects years. The underlying mechanisms Matrine regulations human breast cancer stem cells (BrCSCs) are barely known. LIN28, well‐characterized suppressor Let‐7 microRNA biogenesis, playing vital roles in cells’ renewal and tumorigenesis. Here we show that injection derived could suppress...
Abstract Immune checkpoint blockade, an immunotherapy, has been applied in multiple systemic malignancies and improved overall survival to a relatively great extent; whether it can be breast cancer remains unknown. We endeavored explore possible factors that may influence immunotherapy outcomes using several public databases. The treatment target TNF superfamily member 4 (TNFSF4) was selected from many candidates based on its abnormal expression profile, survival-associated status, ability...
Sepsis-related liver injury (SRLI) is a common condition in critically ill patients, and it associated with poor outcomes. Early identification of sepsis can provide clinicians the abundance information for optimizing treatment strategies improve quality life. Therefore, purpose this study was to establish predictive model assess early value sepsis. In retrospective study, total 1116 patients enrolled from Biobank First Affiliated Hospital Xi'an Jiaotong University were included. According...
Abstract Objective To investigate the risk factors and maternal fetal outcomes of preeclampsia after pregnancy in patients with primary chronic hypertension. Methods A total 500 singleton pregnant women a history hypertension who were admitted for delivery at our Hospital from March 2015 to May 2022 retrospectively collected by random sampling divided into non-occurrence group ( n = 200) occurrence 300) according whether they complicated preeclampsia. Afterward, general data...
The poor therapy response and prognosis of esophageal cancer has made it one the most malignant carcinoma, complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose at an earlier stage, improve effect anticancer would therapeutic efficacy. After retrospective analysis samples patients who received esophagectomy, we found relevance between ratio either ALDH1 or CD133-positive stem cells 2-year recurrence. Higher ratios indicated later clinical...
MiR-146a could stimulate tumor growth or block proliferation in systemic malignancies, referring to the specific downstream targeted gene. However, its roles breast cancer stem-like cells (BrCSCs) are barely known. To dig out mechanistic functions, we explored indicative of miR-146 preclinical study, regardless hormone receptor status, and positive correlation between better prognosis was proved, as Let-7c was. uncover implicated mechanisms, first identified suppressive role miR-146a stem...