A5100431393- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Bioactive natural compounds
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mycobacterium research and diagnosis
- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Parathyroid Disorders and Treatments
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Biological and pharmacological studies of plants
- Phytochemical Studies and Bioactivities
- Phytochemistry and Biological Activities
- Bacteriophages and microbial interactions
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Cytokine Signaling Pathways and Interactions
- Autophagy in Disease and Therapy
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Anhui University of Traditional Chinese Medicine
2025
Tianjin Medical University
2019-2025
Second Hospital of Tianjin Medical University
2025
Changchun University of Chinese Medicine
2025
Texas A&M University
2024
Chongqing Medical University
2024
Henan Provincial People's Hospital
2024
Zhengzhou University
2024
Children's Hospital of Chongqing Medical University
2024
To reveal the potential molecular mechanism of glioblastoma multiforme (GBM) and provide candidate biomarkers for GBM gene therapy. Microarray dataset GSE50161 was obtained from GEO database. The differentially expressed genes (DEGs) were identified between samples control samples, followed by module partition analysis based on WGCNA. Then, pathway functional enrichment analyses DEGs performed. hub further investigated, survival data validation. A total 1913 investigated two groups, 5...
Abstract Background Tyrosine kinase inhibitors (TKIs) that specifically target mutational points in the EGFR gene have significantly reduced suffering and provided greater relief to patients with lung adenocarcinoma (LUAD). The third-generation EGFR-TKI, Osimertinib, has been successfully employed clinical treatments overcome resistance both original acquired T790M L858R points. Nevertheless, issue of treatment failure response emerged as an insurmountable problem. Methods By employing a...
Regulating nuclear export precisely is essential for maintaining mRNA homeostasis and impacts tumor progression. However, the mechanisms governing remain poorly elucidated. Herein, it revealed that enhanced hypoxic long no-ncoding RNA (lncRNA prostate cancer associated transcript 6 (PCAT6) in breast (BC) promotes of m6A-modified mRNAs, bolstering stem cells (BCSCs) stemness doxorubicin resistance. Clinically, PCAT6 correlates with malignant BC features poor prognosis. Mechanically, functions...
Abstract Background Elderly patients often exhibit postoperative cognitive dysfunction (POCD), a postsurgical decline in memory and executive function. Oxidative stress neuroinflammation, both pathological characteristics of the aged brain, contribute to this decline. This study posits that electroacupuncture (EA) stimulation, an effective antioxidant anti‐inflammatory modality, may enhance telomerase reverse transcriptase (TERT) function, catalytic subunit known for its protective...
RNA methylation, catalysed by a set of methyltransferases (RNMTs), modulates structures, properties, and biological functions. RNMTs are increasingly documented to be dysregulated in various human diseases, particularly developmental disorders cancer. However, the genomic transcriptomic alterations RNMTs, as well their functional roles cancer, limited. In this study, we utilized an unbiased approach examine copy number mutation rates 58 more than 10,000 clinical samples across 32 cancer...
SETD1A, a member of SET1/MLL family H3K4 methyltransferases, is involved in the tumorigenesis numerous cancers. However, biological role and mechanism SETD1A non-small cell lung cancer (NSCLC) remain to be elucidated.The expression NEAT1, EZH2, β-catenin NSCLC tissues lines was detected by qRT-PCR, immunohistochemistry western blotting. The regulatory mechanisms were validated chromatin immunoprecipitation, co-immunoprepitation luciferase reporter assay. self-renewal, cisplatin sensitivity...
The small tyrosine kinase inhibitors (TKIs) subversively altered the lung cancer treatments, but patients will inevitably face therapy resistance and disease recurrence. We aim to explore potential roles of non-coding RNAs in sensitizing TKIs effects. Multiple cellular molecular detections were applied confirm mechanistic regulations intracellular connections. explored specific gene features candidates association with resistance, found that m6A controlled stemness EMT through METTL3 YTHDF2....
Background N6-methyladenosine (m6A) is the most abundant internal mRNA modification in eukaryotic cells. There accumulating evidence that m6A methylation can play a significant role early diagnosis and treatment of cancers. However, mechanism underlying involvement cervical cancer remains unclear. Methods Here, we examined patterns immune cells tumour microenvironments (TMEs) 306 patients with from The Cancer Genome Atlas dataset analysed relations between them according to 32 regulators....
Abstract Background Tumor metastasis is a major threat to cancer patient survival. The organ‐specific niche plays pivotal role in tumor organotropic metastasis. Fibroblasts serve as vital component of the metastatic microenvironment, but how heterogeneous metastasis‐associated fibroblasts (MAFs) promote poorly characterized. Here, we aimed decipher heterogeneity MAFs and elucidate distinct roles these pulmonary formation breast cancer. Methods Mouse models were established using an vivo...
We determined the therapeutic efficacy of atractylenolide I (ATR), extracted from largehead atractylodes rhizome, in managing gastric cancer cachexia (GCC), and interpreted its probable pharmacological mechanism via investigating tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), interleukin-6 (IL-6) proteolysis-inducing (PIF). This was a randomized but not-blinded pilot. The study group (n = 11) received 1.32 g per day (ATR) control 3.6 fish-oil-enriched nutritional...
Abstract It was recently revealed that 5‐methylcytosine (5mC) in mRNA, similar to its behavior DNA, can be oxidized produce 5‐hydroxymethylcytosine (5hmC) and 5‐formylcytosine (5fC), implying the potential regulatory roles of this post‐transcriptional RNA modification. In study, we demonstrate vitro oxidation 5fC 5‐carboxycytidine (5caC) by catalytic domain mammalian ten‐eleven translocation enzyme (TET1) different contexts. We observed process has very low sequence dependence take place...
Epigenetic silencing of promoter and enhancer regions is a common phenomenon in malignant cells. The transcription factor STAT3 aberrantly activated several tumors, where its constitutive acetylation accounts for the transcriptional repression number tumor suppressor genes (TSG) via molecular mechanisms that remain to be understood. Using nucleophosmin-anaplastic lymphoma kinase-positive (NPM-ALK+) anaplastic large-cell (ALCL) as model system, we found cells patient-derived xenografts...
Radian Sophorae flavescentis is a traditional Chinese medicine commonly used to treat cancer in China. However, its active components and underlying mechanism remain ambiguous. In this study, we have screened the pharmacokinetic parameters of main chemical constituents by Traditional Medicine Systems Pharmacology (TCMSP) Database Analysis Platform found that Sophoridine one best antitumor ingredients. We MAPKAPK2 potential target for PharmMapper KEGG databXase analysis. Moreover, selectively...
Abstract Background Smac mimetics are a type of drug that can induce apoptosis by antagonizing IAP family members in cancer treatment. However, recent study showed trigger cell invasion and migration cells activating the NF-κB pathway. Methods We assessed lung elongation, under treatment with mimetic LCL161. Functional analyses (in vitro vivo) were performed to detect contribution NIK OTUD7B LCL161-induced migration. The role regulation TRAF3/NIK/NF-κB pathway LCL161 was analysed...
Abstract TNF receptor‐associated factor 3 interacting protein (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated most malignancies and critical for immune regulation. However, the specific effects molecular mechanisms of TRAF3IP3 on progression lung adenocarcinoma (LUAD) remains poorly understood. This study reveals is several tumor tissues but exclusively decreased LUAD Lung squamous cell carcinoma (LUSC) tissues, consequential a favorable overall survival (OS)...
LRPPRC is a multifunctional protein involved in mitochondrial gene expression and function, cell cycle progression, tumorigenesis. We analyzed 253 paired cases of gastric cancer noncancerous regions six lines to demonstrate the importance for prediction prognosis cancer. Our results showed that tissues significantly higher than control tissue (P < 0.001). Patients with poorer overall survival rate those lower Multivariate analysis demonstrated lymph node metastasis (N), distant (M), TNM...