A5100322253- RNA modifications and cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Traditional Chinese Medicine Analysis
- Bioactive Natural Diterpenoids Research
- Plant-based Medicinal Research
- Cancer-related molecular mechanisms research
- Microbial Metabolism and Applications
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Autophagy in Disease and Therapy
- Cancer Treatment and Pharmacology
- Antimicrobial Resistance in Staphylococcus
- RNA Research and Splicing
Henan Cancer Hospital
2025
Zhengzhou University
2021-2025
Peking University
2017-2022
Peking University Third Hospital
2022
Henan University
2022
University of California, Davis
2020-2021
Peking University Cancer Hospital
2017-2019
Ministry of Education
2018
Texas A&M Health Science Center
2016
Shenyang Pharmaceutical University
2012-2014
Anabolism and catabolism are tightly regulated according to the cellular energy supply. Upon stress, ribosomal RNA (rRNA) biogenesis is inhibited, autophagy induced. However, mechanism linking rRNA unclear. Here, we demonstrate that nucleolar protein NAT10 plays a role in transition between autophagy. Under normal conditions, acetylated activate inhibit induction. Mechanistic studies binds acetylates regulator Che-1 at K228 suppress Che-1-mediated transcriptional activation of downstream...
Abstract It was recently revealed that 5‐methylcytosine (5mC) in mRNA, similar to its behavior DNA, can be oxidized produce 5‐hydroxymethylcytosine (5hmC) and 5‐formylcytosine (5fC), implying the potential regulatory roles of this post‐transcriptional RNA modification. In study, we demonstrate vitro oxidation 5fC 5‐carboxycytidine (5caC) by catalytic domain mammalian ten‐eleven translocation enzyme (TET1) different contexts. We observed process has very low sequence dependence take place...
Background: Human N-acetyltransferase 10 (NAT10) plays pivotal roles in cellular biological processes, such as senescence, autophagy and cytokinesis. The expression of NAT10 is dysregulated colorectal cancer (CRC) associated with the prognosis patients. However, it remains unclear how regulated CRC. Methods: microRNA(miRNA) regulating was predicted by bioinformatics analysis further validated real-time quantitative PCR(RT-qPCR),Western blot dual luciferase reporter assays. miRNA CRC tissues...
For patients with breast cancer, the amplification of Human Epidermal Growth Factor 2 (HER2) is closely related to their prognosis and treatment decisions. This study aimed further improve accuracy efficiency HER2 status detection a deep learning model, apply model predict efficacy neoadjuvant therapy. We combined Next-Generation Sequencing (NGS) data IHC staining images 606 cancer developed Vision Transformer (ViT) identify through these images. was then applied therapy in 399 HER2-positive...
Long noncoding RNAs (lncRNAs) play an important role in the tumorigenesis and progression of human cancer. This research was performed to investigate LINC01296 clinical characteristics, biological functions molecular mechanisms bladder cancer.In this study, expressions cancer tissues normal were firstly compared using Gene Expression Profiling Interactive Analysis database. Subsequently, a microarray data analysis compare lncRNA mRNA expression profiles four pairs samples. Then, quantitative...
Human U three protein 14a (hUTP14a) promotes p53 degradation. Moreover, hUTP14a expression is upregulated in several types of tumors. However, the pattern hepatocellular carcinoma (HCC) remains unknown. The aim this study was to investigate and its prognostic value HCC. evaluated using immunohistochemistry (IHC) HCC tissue specimens. correlations between clinicopathological variables were analyzed. Kaplan-Meier method used analyze association survival. Independent factors associated with...
MicroRNAs (miRNAs or miRs) are small noncoding RNAs derived from genome to control target gene expresion. Recently we have developed a novel platform that offers high‐yield production of bioengineered miRNA agents (BERAs). This study was produce and utilize fully‐humanized biologic miR‐328‐3p molecule (hBERA/miR‐328) delineate the role in nutrient uptake essential for cell metabolism. We first demonstrated successful high‐level expression hBERA/miR‐328 bacteria purification high degree...
Metabolism of cancer cells is different from normal and heterogeneous. To meet energetic material needs for high-rate proliferation tumorigenesis, generally rely more heavily on vital exogenous nutrients (e.g. glucose, amino acids, vitamins) than cells. Therefore, control nutrient transport metabolism in a novel anticancer strategy. Our previous studies have suggested that microRNA-1291-5p (miR-1291-5p) downregulated pancreatic (PC) acts tumor suppressor. The current study aimed to develop...