A5101770900- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Computational Drug Discovery Methods
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Protein Hydrolysis and Bioactive Peptides
- GABA and Rice Research
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Medicinal Plants and Neuroprotection
- Lipid metabolism and biosynthesis
- Cancer, Stress, Anesthesia, and Immune Response
- Breast Cancer Treatment Studies
- Probiotics and Fermented Foods
- Genomics and Phylogenetic Studies
- Infant Nutrition and Health
- Machine Learning in Bioinformatics
- Animal Diversity and Health Studies
- Bioinformatics and Genomic Networks
- Biomedical Text Mining and Ontologies
- Natural Antidiabetic Agents Studies
- NF-κB Signaling Pathways
Weihai Municipal Hospital
2025
Shandong University
2025
University of Hong Kong
2025
Guangzhou Medical University
2015-2024
Bridge University
2024
Guangdong Provincial People's Hospital
2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Changzhi Medical College
2024
South China University of Technology
2016-2023
The associations between genes and diseases are of critical significance in aspects prevention, diagnosis treatment. Although gene-disease relationships have been investigated extensively, much the underpinnings these yet to be elucidated.A novel method integrates MeSH database, term weight (TW), co-occurrence methods predict based on cosine similarity gene vectors disease vectors. Vectors transformed from texts documents PubMed database according appearance location or terms. related text...
Let-7 miRNAs act as tumour suppressors by directly binding to the 3'UTRs of downstream gene products. The regulatory role let-7 in expression has gained much interest cancer research community, it controls multiple biological functions and determines cell fates. For example, one target family is cyclin D1, which promotes G0/S cycle progression oncogenesis, was correlated with endoribonuclease DICER1, another let-7. Down-regulated been identified many types tumours, suggesting a feedback loop...
Non‑small‑cell lung cancer (NSCLC) is well established as one of the major subtypes human cancer. NSCLC characterized by a high incidence rate and poor patient prognosis. Previous studies have identified that long intergenic non-coding RNA (lincRNA) serves key role in development tumor malignant metastasis. However, majority underlying mechanisms for lincRNA deregulation various diseases, including diabetes, not been completely elucidated. In present study, lincRNA‑p21 tissues comparison to...
Elucidating the mechanism for high metastasis capacity of Endometrial cancer (EC) is crucial to improve treatment outcomes EC. We have recently reported that nicotinamide N-methyltransferase (NNMT) overexpressed in EC, especially and predicts poor survival chemotherapy patients. Here, we aimed determine function NNMT on Additionally, analysis public datasets indicated involved cholesterol metabolism. In vitro, overexpression promoted migration invasion EC by reducing levels cytoplasm cell...
Determination of sequence similarity is one the major steps in computational phylogenetic studies. One tasks biologists to develop novel mathematical descriptors for analysis. DNA clustering an important technology that automatically identifies inherent relationships among large-scale sequences. The comparison between sequences different species helps determine species. Alignment-free approaches have continuously gained interest various analysis applications such as inference and metagenomic...
With the acceleration of pace life, people may face all kinds pressure, and anxiety has become a common mental issue that is seriously affecting human life. Safe effective food-derived compounds be used as anti-anxiety compounds. In this study, were collected curated for database construction. Quantitative structure-activity relationship (QSAR) models developed using combination various machine-learning approaches chemical descriptors to predict natural in food with effects. High-throughput...
Phenotypes and diseases are often determined by the complex interactions between genetic factors environmental (EFs). However, compared with protein-coding genes microRNAs, there is a paucity of computational methods for understanding associations long non-coding RNAs (lncRNAs) EFs. In this study, we focused on lncRNA By using common miRNA partners any pair EF, based competing endogenous RNA (ceRNA) hypothesis technique resources transfer within experimentally-supported lncRNA-miRNA miRNA-EF...
The incidence rate of gliomas is the highest among primary brain tumors. Although understanding molecular pathology glioma has improved during previous two decades, effective therapies are not yet available to treat these Previous studies have indicated that long non-coding RNAs (lncRNAs) a close association with glioma, suggesting lncRNAs may be potential targets for development novel treatments glioma. present review summarized latest on dysregulation in and discussed their use diagnosis,...
Abstract Breast cancer (BRCA) is characterized by a unique metastatic pattern, often presenting with bone metastasis (BoM), posing significant clinical challenges. This study employs single-cell RNA sequencing and TCGA data analysis to comprehensively compare primary tumors (PT), lymph node (LN), BoM. Our investigation identifies niche in BoM marked an increased abundance of cancer-associated fibroblasts (CAFs) reduced immune cell presence. A distinct subtype (State 1) BRCA cells associated...
Abstract Breast cancer (BRCA) is characterized by a unique metastatic pattern and often presents with bone metastasis (BoM), which poses significant clinical challenges. This study employed single-cell RNA sequencing (scRNA-seq) TCGA data analysis to compare primary tumor (PT), lymph node (LN), BoM data. Our investigation identified niche in BoMs marked an increased abundance of cancer-associated fibroblasts (CAFs) reduced immune cell count. A distinct subtype (State 1) BRCA cells associated...
Endometrial cancer (EC) represents a serious health concern among women globally. Excessive activation of the protooncogene c-Myc (c-Myc) is associated with proliferation and stemness EC cells. Phosphocholine (PC), which synthesized by choline kinase alpha (CHKA) catalysis, upregulated in tumor tissues. The present study aimed to investigate effect PC accumulation on cells clarify relationship between activity EC. CHKA expression tissues were examined using immunohistochemistry. Cell...
Objective To evaluate the clinical and pathologic response toxicity of cyclophosphamide epirubicin fluorouracil as neoadjuvant chemotherapy in treatment breast cancer, observe long-term effect. Methods From January 2001 to June 2006, 89 patients confirmed cancer by core needle biopsy were enrolled onto this trial treated with chemotherapy,the regimen containing 600 mg/m2 (day 1) 100 5-fluorouracil 500 (FEC100) was administered every 3 weeks for 4 cycles before local...
Molecular weight is one of the main characteristic parameters proteins, which basis for study such as protein homogeneity, aggregation state and protein-protein interaction. This research aims at establishing molecular distribution pattern milk based on gel permeation chromatography in order to analyze differences between different types guide infant formula development. After verification, established detection method accurate. The distributions samples were determined using this method,...