A5101976614- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Autoimmune Neurological Disorders and Treatments
- Intensive Care Unit Cognitive Disorders
- Cardiac Ischemia and Reperfusion
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Radiopharmaceutical Chemistry and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Metabolism, Diabetes, and Cancer
- Salivary Gland Disorders and Functions
- Organ Transplantation Techniques and Outcomes
- Amino Acid Enzymes and Metabolism
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Infectious Diseases and Tuberculosis
- Adipose Tissue and Metabolism
- Cellular transport and secretion
- Pharmacological Effects and Toxicity Studies
- Chronic Myeloid Leukemia Treatments
- Fibroblast Growth Factor Research
Shandong Provincial Hospital
2013-2025
Shandong First Medical University
2021-2025
Beijing National Laboratory for Molecular Sciences
2018-2024
Peking University
2011-2024
Hebei Medical University
2013-2023
Harbin Medical University
2022-2023
Third Affiliated Hospital of Harbin Medical University
2022-2023
Second Hospital of Hebei Medical University
2014-2023
Sun Yat-sen University
2015-2020
Fifth Affiliated Hospital of Sun Yat-sen University
2015-2020
The classical photodynamic therapy (PDT) requires external light to activate photosensitizers for cancer treatment. However, limited tissue penetration of has been a long-standing challenge PDT cure malignant tumors in deep tissues. Recently, Cerenkov radiation (CR) emitted by radiotracers such as 18F-fluorodeoxyglucose (18F-FDG) become an alternative and promising internal source. Nevertheless, fluorine-18 (F-18) only releases 1.3 photons per decay average; consequently, injection dose F-18...
There are epidemiological and experimental evidences that metformin, an insulin-sensitizer agent widely used for diabetes treatment, has inhibitory effects on the growth of various human cancers. However, underlying molecular mechanisms its anti-neoplastic activity not been yet clarified effect metformin lung cancer remains unknown. In this study we revealed first time treatment led to increased apoptosis in cell lines A549 NCI-H1299 significantly inhibited cells proliferation a dose-...
Recently, inhibiting the PD-1/PD-L1 checkpoint pathway utilizing anti-PD-1 or anti-PD-L1 antibodies has achieved great clinical success in cancer treatment. However, immunotherapy cannot be applied to all patients, no more than 25% showed a positive response. Immunohistochemistry (IHC) is gold standard determine PD-L1 expression level malignant lesions, but noninvasive imaging-meditated strategy urgently required for diagnosis cover shortcomings of invasive techniques. MX001, which an...
Leptin levels are increased in patients with systemic lupus erythematosus (SLE) but little is known on how this correlates several disease characteristics including the frequency of regulatory T cells (Tregs). Here we compared serum leptin circulating Tregs 47 vs. 25 healthy matched controls. Correlations activity were also analyzed, as well Treg proliferation potential. It was found that remarkably SLE to controls, particularly moderate and severe active SLE, increase correlated activity....
Abstract Natural products are a rich resource for the discovery of therapeutic substances. By directly using 504 fine fractions from isolated traditional Chinese medicine plants, we performed transgenic zebrafish based screen anti-angiogenesis One fraction, DYVE-D3, was found to inhibit growth intersegmental vessels in vasculature. Bioassay-guided isolation DYVE-D3 indicates that flavonoid kaempferol active substance. Kaempferol also inhibited proliferation and migration HUVECs vitro ....
Late-onset epilepsy due to autoimmune dysfunction has been reported. However, definitive diagnosis requires positive antibody results. As a result, patients with negative results, but presenting classical manifestation of epilepsy, may be managed as suspected cases. In this study, we aim isolate and profile the concentration cytokines/chemokines in cerebrospinal fluid (CSF) serum ascertain if they could act alternative diagnostic biomarkers.Twenty aged ≥50 years were considered study. Ten...
Cognitive-behavioral stress management (CBSM) is a psychotherapy that helps patients cognize and manage to improve mental health quality of life. This study aimed explore the influence CBSM on anxiety, depression, life in non-small cell lung cancer (NSCLC) patients.In total, 172 NSCLC who received tumor resection were randomized 1:1 into usual care (UC) group (N = 86) receive 10-week UC interventions. Moreover, all participants attended 6-month follow-up.Hospital Anxiety Depression Scales...
Abstract The type II CRISPR/Cas9 system has been used widely for genome editing in zebrafish. However, the requirement 5′-NGG-3′ protospacer-adjacent motif (PAM) of Cas9 from Streptococcus pyogenes (SpCas9) limits its targeting sequences. Here, we report that a ortholog Staphylococcus aureus (SaCas9), and KKH variant, successfully induced targeted mutagenesis with high frequency Confirming previous findings, SpCas9 VQR, can also induce mutations Bioinformatics analysis these new Cas targets...
Amino acids derivative are well established molecular probes for diagnosis of a variety cancer using positron emission tomography (PET). Recently, boramino acid (BAAs) was found as prospective platform developing PET tracer. The objective this study to develop 18F-labeled alanine through displacing its carboxylate by trifluoroborate selective ASCT2 marker imaging. 18F-Ala-BF3 first evaluated in healthy FVB/N mice vivo, exhibiting rapid renal clearance with almost negligible uptake stomach...
Similar to glycolysis, glutaminolysis acts as a vital energy source in tumor cells, providing building blocks for the metabolic needs of cells. To capture tumors, 18F-(2S,4R)4-fluoroglutamine ([18F]FGln) and 18F-fluoroboronoglutamine ([18F]FBQ) have been successfully developed positron emission tomography (PET) imaging, but these two molecules lack stability, resulting undesired yet significant bone uptake. In this study, we found that [18F]FBQ-C2 is stable Gln PET tracer by adding more...
Hepatocellular carcinoma (HCC) is one of the most common malignancies with a rising incidence around world. MicroRNAs (miRNAs) have been reported to play essential roles in progression HCC. However, precise mechanism miR-3662 HCC process remains poorly understood. This study was aimed determine regulatory network and hexokinase 2 (HK2) Quantitative real-time polymerase chain reaction (qRT-PCR) performed detect expression. Cell proliferation invasion were measured by Counting Kit-8 (CCK-8)...
Correct specification of the left-right (L-R) axis is important for organ morphogenesis. Conserved mechanisms involving cilia rotation inside node-like structures and asymmetric Nodal signaling in lateral plate mesoderm (LPM), which are symmetry-breaking events, have been intensively studied. In zebrafish, clustering migration dorsal forerunner cells (DFCs) critical formation Kuppfer's vesicle (KV). However, molecular events underlying DFC less understood. The WD-repeat proteins function a...
Sjogren's syndrome (SS) is a chronic autoimmune disease, particularly involving the lacrimal and salivary glands, with dryness as main symptom. To date, pathogenesis of SS not fully understood. Recently, numerous miRNAs were implicated in etiology pathogenesis.Ocular wash was collected from patients healthy controls. INF-γ-treated gland epithelial cells (SGECs) utilized vitro models. Expressions miR-223-3p inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) ocular specimens measured by...