A5102841802- Immune Response and Inflammation
- Antimicrobial Resistance in Staphylococcus
- Lung Cancer Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Immunotherapy and Immune Responses
- Sirtuins and Resveratrol in Medicine
- Esophageal Cancer Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Nanoparticles: synthesis and applications
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Antimicrobial Peptides and Activities
- NF-κB Signaling Pathways
- FOXO transcription factor regulation
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Cytokine Signaling Pathways and Interactions
- Photodynamic Therapy Research Studies
- Medicinal plant effects and applications
- Telomeres, Telomerase, and Senescence
- Actinomycetales infections and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Pediatric Hepatobiliary Diseases and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
Second Affiliated Hospital of Xi'an Jiaotong University
2025
South China Normal University
2024
East China Normal University
2024
Third Affiliated Hospital of Guangzhou Medical University
2023
Guangzhou Medical University
2023
Sun Yat-sen University
2009-2021
Third Affiliated Hospital of Sun Yat-sen University
2008-2021
Ningbo University
2014-2019
Ningbo Medical Center Lihuili Hospital
2014-2019
University of Colorado Anschutz Medical Campus
2018
Cancer cell radioresistance is the primary cause of decreased curability non–small lung cancer (NSCLC) observed in patients receiving definitive radiotherapy (RT). Following RT, a set microenvironmental stress responses triggered, including senescence. However, senescence often ignored designing effective strategies to resolve radioresistance. Herein, we identify senescence-like characteristics cancer-associated fibroblasts (CAFs) after RT and clarify formidable ability CAFs promoting NSCLC...
Non-small cell lung cancer is one of the leading causes cancer-related death worldwide. MicroRNAs have been characterized as critical regulators for progression including non-small cancer. This work explored microRNA-744-5p expression in lines and normal line using quantitative real-time polymerase chain reaction. Connection paired box 2 was analyzed with bioinformatic analysis, luciferase activity reporter assay, Western blot. Effects or on behaviors were a series vitro experiments....
460 Background: For patients with inoperable oesophageal cancer, simultaneous radiotherapy is the standard treatment option. However, elderly are often unable to tolerate CCRT, so a safe, effective and tolerable option needed. Tegafur, derivative of 5-FU, has shown efficacy safety in cancer. This clinical study evaluated toxicity combined Tegafur bolus Methods: In this study, 62 unresectable intermediate advanced ESCC (stage IIA IVA) between March 2022 February 2024 were screened divided...
Fundamental studies have suggested that matrix metalloproteinases-7 (MMP-7) expression is associated with chemoresistance and constitutes a prognostic factor in several solid tumors. The present study assessed the predictive value of MMP-7 tumors patients advanced non-small cell lung cancer (NSCLC) treated platinum-based chemotherapy. In total, 159 stage III IV NSCLC were retrospectively enrolled. Immunohistochemistry was performed to evaluate MMP-7, apoptosis-related proteins Bcl-2, Bax,...
Background Nuclear factor erythroid 2–related 2 (Nrf2), a master regulator of the antioxidant host defense, maintains cellular redox homeostasis. Methods This study was designed to investigate role and molecular mechanisms by which Nrf2 regulates toll-like receptor (TLR)4-driven inflammation response in mouse model hepatic warm ischemia (90 min) reperfusion (6 hr) injury (IRI). Results Activation after preconditioning wild-type recipients with cobalt protoporphyrin ameliorated liver IRI,...
Nicotinamide phosphoribosyltransferase (NAMPT) is an important neuroprotective factor in cerebral ischemia, and it has been reported that NAMPT inhibitors can aggravate neuronal injury the acute phase. However, because a cytokine, participates many inflammatory diseases peripheral system, its have therapeutic effects. Following resident immune cells produce pro-inflammatory mediators ischemic area, which induce neuroinflammation impair brain. effects of after brain remain unknown. Here, we...
Abstract Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme of salvage pathway nicotinamide adenine dinucleotide synthesis. NAMPT can also be secreted and functions as a cytokine. We have previously shown that in brain, expression secretion induced microglia upon neuroinflammation injury. Yet mechanism for remains unclear. Here we show actively from treatment ischemia‐like injury – oxygen‐glucose deprivation recovery (OGD/R). confirmed classical ER‐Golgi not involved secretion....
To clarify the clinical features and imaging characteristics of non-AIDS patients with pulmonary cryptococcosis.We retrospectively collected 15 HIV-negative pathology-proved cryptococcosis from Sep 1992 to Jan 2008. Their medical records radiological data were reviewed analyzed.Only one patient was asymptomatic.Thirteen immunocompetent two immunosuppressed. Three had associated meningitis. The most common radiographic abnormalities multiple nodules or masses, seen in 8 5 cases respectively....
The purpose of this study was to investigate the efficacy and safety drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Chinese hepatocellular carcinoma (HCC) patients prognostic factors for response as well survival. A total 275 HCC were included prospective study. Treatment assessed by modified Response Evaluation Criteria Solid Tumors (mRECIST), progression-free survival (PFS) overall (OS) determined. Liver function adverse events (AEs) before after DEB-TACE...
Heat shock protein 70 (HSP70) was a highly conserved which significantly induced in response to cellular stresses. HSP70 played an important role the pathogenesis of cancer stabilized production large amount oncogenic proteins and finally supported growth survival tumor. However, there no report about diagnosis circulating lung patients. In this study, total 297 participants (lung cancer: 197, healthy control: 100) were enrolled detection level plasma by ELISA assay. The results indicated...
Hepatitis B virus (HBV) is a hepatotropic DNA virus, and its may be potent inflammatory molecule. Interferon-inducible protein 16 (IFI16), newly discovered sensor, plays an important role in the process of inflammation viral infections. Our study sought to identify correlation between IFI16 expression patients with chronic hepatitis (CHB) HBV-associated acute-on-chronic liver failure (HBV-ACLF). We performed flow cytometry measure levels peripheral blood mononuclear cells (PBMC) used...
Adenoviral vectors expressing Cre recombinase are commonly used to initiate tumor formation in murine lung cancer models. While these designed target genetic recombination epithelial cells, adenoviruses can infect additional cell types that potentially influence development. Our goal was explore the consequences of adenoviral-mediated alveolar macrophage (AM) transduction a Kras-initiated model. As expected, treatment animals harboring KrasLSL-G12D allele and an inducible green fluorescence...
Early diagnosis of pancreatic cancer, one the most deadly cancers with low survival rates, is difficult, and effective biomarkers are urgently needed. Lipopolysaccharide-induced tumor necrosis factor-α factor (LITAF) has been recently proposed as a potential suppressor gene in several types cancer. Here, we analyzed biological function LITAF The protein levels were decreased tissues compared their paired adjacent non-cancerous tissues. In addition, patients lower expression had disease-free...
Panton–Valentine leukocidin (PVL) is associated with rare cases of necrotizing pneumonia that occur in otherwise healthy individuals. Human alveolar macrophages (HAMs) are major effector cells host defense against infections. However, the impact PVL on HAMs uncertain. We evaluated role cytotoxicity and production inflammatory cytokines secreted by HAMs. were purified from bronchoalveolar lavage fluid. Recombinant (rPVL) was used study to interfere HAM apoptosis cytokine vitro. Hoechst 33342...
Herein, we have designed and developed a heteromultivalent chitosan base α -Fe 2 O 3 /Gadofullerene (GdF) hybrid composite through simple chemical precipitation method. Unlike other methods, the addition of external stabilizing agents to generate GdF nanoparticles (NPs) was not necessary herein. The prepared chitosan- /GdF nanocomposites were characterized using UV, FT-IR, XRD morphological microscopic analyses. results showed that successfully grown on surface chitosan. FT-IR vibration...
Abstract Objectives Metabolic syndrome (MS) is the concurrence of at least three five medical conditions: obesity, high blood pressure, insulin resistance, serum triglyceride (TG) and low high-density lipoprotein levels. While fibrates are used to treat disorders other than lowering TG, mechanism by which decrease MS has not been established. Methods In this study, wild-type Ppara-null mice fed a medium-fat diet (MFD) were administered gemfibrozil fenofibrate for 3 months respectively,...
This article displays synthesis of Silver nanoparticles (Ag NPs) decorated on sodium alginate covered magnetite (Fe3O4/Alg-Ag nanocomposite. Sodium shell as a natural anionic polysaccharide Fe3O4 microparticles core acted stabilizing agent for the reduction Ag(I) ions into Ag NPs. The structural features synthesized nanocomposite were investigated by fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopes (FE-SEM), transmission...
Lipase G, endothelial type (LIPG) is expressed abundantly in tissues with a high metabolic rate and vascularisation. Research on LIPG has focussed syndromes. However, the role of providing lipid precursors suggests that it might function metabolism carcinoma cells. Analysis The Cancer Genome Atlas indicated patients cervical expression had lower survival prognosis compared low expression. mechanism underlying effects unclear. present study aimed to determine its mechanism. results showed...