A5101618673- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Cancer Immunotherapy and Biomarkers
- Curcumin's Biomedical Applications
- Trace Elements in Health
- Viral gastroenteritis research and epidemiology
- Pharmacogenetics and Drug Metabolism
- Liver Diseases and Immunity
- Lung Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Metabolism, Diabetes, and Cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Adipose Tissue and Metabolism
Jiangxi Agricultural University
2021
Peking University
2021
Ningbo University
2016-2018
Background and Purpose Fenofibrate, a PPARα agonist, is the most widely prescribed drug for treating hyperlipidaemia. Although fibrate drugs are reported to be beneficial cholestasis, their underlying mechanism has not been determined. Experimental Approach Wild‐type mice Pparα ‐null were pretreated orally with fenofibrate 3 days, following which α‐naphthylisothiocyanate (ANIT) was administered induce cholestasis. The agonist WY14643 JNK inhibitor SP600125 used determine role of pathway,...
α-Naphthylisothiocyanate (ANIT) is an experimental agent used to induce intrahepatic cholestasis. The Ppara-null mouse line widely employed explore the physiological and pathological roles of PPARα. However, little known about how PPARα influences hepatotoxicity ANIT. In present study, wild-type mice were orally treated with ANIT serum metabolome segregated from that mice, driven by changes bile acid (BA) metabolites. Alkaline phosphatase total BAs elevated preferentially in which correlated...
Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, causes neonatal pig acute gastrointestinal infection with a characterization of severe diarrhea, vomiting, high morbidity, and mortality, resulting in tremendous damages to the swine industry. Neither specific antiviral drugs nor effective vaccines are available, posing priority screen drugs. The aim this study is investigate anti-PEDV effects carbazole alkaloid derivatives. Eighteen derivatives (No.1 No.18) were synthesized,...
Abstract Gemfibrozil, a peroxisome proliferator‐activated receptor α ( PPAR α) agonist, is widely used for hypertriglyceridaemia and mixed hyperlipidaemia. Drug–drug interaction of gemfibrozil other agonists has been reported. However, the role in cytochrome P450 CYP ) induction by fibrates not well known. In this study, wild‐type mice were first fed gemfibrozil‐containing diets (0.375%, 0.75% 1.5%) 14 days to establish dose–response relationship induction. Then, Ppar α‐null treated with...
Abstract Objectives Metabolic syndrome (MS) is the concurrence of at least three five medical conditions: obesity, high blood pressure, insulin resistance, serum triglyceride (TG) and low high-density lipoprotein levels. While fibrates are used to treat disorders other than lowering TG, mechanism by which decrease MS has not been established. Methods In this study, wild-type Ppara-null mice fed a medium-fat diet (MFD) were administered gemfibrozil fenofibrate for 3 months respectively,...