A5101772833- Facial Trauma and Fracture Management
- Facial Nerve Paralysis Treatment and Research
- Dental Radiography and Imaging
- Acute Myeloid Leukemia Research
- Temporomandibular Joint Disorders
- Immune Cell Function and Interaction
- Reconstructive Surgery and Microvascular Techniques
- Immunotherapy and Immune Responses
- Digital Imaging for Blood Diseases
- Bone Tissue Engineering Materials
- Complement system in diseases
- Reconstructive Facial Surgery Techniques
- Tracheal and airway disorders
- Hematological disorders and diagnostics
- Head and Neck Surgical Oncology
- Traumatic Ocular and Foreign Body Injuries
- T-cell and B-cell Immunology
- Peripheral Nerve Disorders
- Immune cells in cancer
- Lymphoma Diagnosis and Treatment
- GDF15 and Related Biomarkers
- Ear Surgery and Otitis Media
- Additive Manufacturing and 3D Printing Technologies
- Vestibular and auditory disorders
- Graphene and Nanomaterials Applications
Peking University
2025
Peking University Third Hospital
2025
Shanghai Ninth People's Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
Institute of Hematology & Blood Diseases Hospital
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Shanghai East Hospital
2024
National Clinical Research
2019-2023
National Clinical Research Center for Digestive Diseases
2021-2022
Renji Hospital
2009-2021
Environmental lipids are essential for fueling tumor energetics, but whether these exogenous transported into cancer cells facilitate immune escape remains unclear. Here, we find that CD36, a transporter lipids, promotes acute myeloid leukemia (AML) evasion. We show that, separately from its established role in lipid oxidation, CD36 on AML senses oxidized low-density lipoprotein (OxLDL) to prime the TLR4-LYN-MYD88-nuclear factor κB (NF-κB) pathway, and palmitate transfer via further...
Abstract A new mini‐deposition system (MDS) was developed to fabricate scaffolds with interconnected pore structures and anatomical geometry for bone tissue engineering. Polycaprolactone/hydroxyapatite (PCL/HA) composites varying hydroxyapatite (HA) content were adopted manufacture by using MDS a porosity of 54.6%, size 716 μm in the x ‐ y plane, 116 z direction. The water uptake ratio compressive modulus PCL/HA composite scaffold increase from 8 39% 26.5 49.8 MPa, respectively, as HA...
Abstract Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid (AML). Here, we report that UHRF1, an epigenetic regulator recruits DNMT1 to methylate DNA, is highly expressed in AML and predicts poor prognosis. UHRF1 required for leukemogenesis by maintaining LICs. Mechanistically, directly interacts with Sin3A-associated protein 30 (SAP30) through two critical amino acids, G572 F573 its SRA domain, repress gene expression. Depletion or SAP30 derepresses...
Drug resistance is a major concern in the successful treatment of ovarian cancer. In present study we report combinational drug regime using arsenic trioxide (ATO) and cisplatin (CDDP) to increase therapeutic potentiality cancer cells. ATO-mediated growth inhibition apoptosis human suspension COC1 cells were evaluated by MTT assay annexin V flow cytometry, respectively. cDNA arrays performed screen gene expression. Treatment with ATO alone resulted dose-and time-dependent fashion; further...
Abstract Background Previously some groups demonstrated that CD44 variant 6 (CD44v6) is correlated with progression and metastasis of ovarian cancer. However, a number other failed to find such an association. Moreover, epithelial cancer known easily metastasize distinct sites as the pelvic abdominal cavities, but potential association CD44v6 expression site-specific has not been explored. This study sought evaluate standard (CD44s) in primary, metastatic recurrent explore CD44s tumor...
Chemo-resistance is still a major obstacle in efforts to overcome acute myeloid leukemia (AML). An emerging concept has proposed that interactions between the bone marrow (BM) microenvironment and cells reduce sensitivity of chemotherapy. As an important element tumor microenvironment, cancer-associated fibroblasts (CAFs) are considered be activated modulators chemo-resistance many solid tumors. But their contribution AML yet fully understood. Here we report critical role for CAFs which were...
Objective. To evaluate the value of high-resolution ultrasonography and neural electrophysiology in early diagnosis, operative opportunity selection, clinical effect assessment DPN. Methods. Five hundred sixty patients with diabetic peripheral neuropathy (DPN) were treated DELLON surgical nerve decompression our hospital past 5 years. Before after 18 months surgery, tests Toronto scoring system, ultrasonography, QST, Nerve Conduction Velocity (NCV) evaluated all cases. The control group...
Abstract Background The molecular diversity exhibited by diffuse large B-cell lymphoma (DLBCL) is a significant obstacle facing current precision therapies. However, scoring using the International Prognostic Index (IPI) inadequate when fully predicting development of DLBCL. Reprogramming lipid metabolism crucial for DLBCL carcinogenesis and expansion, while predictive approach derived from metabolism-associated genes (LMAGs) has not yet been recognized Methods Gene expression profiles were...
The present study investigated the detailed in vitro osteogenic differentiation process and vivo bone regenerative property of human amniotic epithelial cells (hAECs). hAECs was evaluated by biochemical staining, real-time polymerase chain reaction, immunofluorescence. Next, β-tricalcium phosphate (β-TCP) scaffolds alone or loaded with were implanted into alveolar defects rats. Micro-computed tomography evaluation histologic studies conducted. Our results validated capacity upregulation...
The adipocyte remodeling, including of the morphological change, might indicate special pathological function. Our previous study found that remodeling larger marrow adipocytes into small correlates with a poor prognosis for acute myeloid leukemia (AML) patients. However, mechanisms contributed to are still poorly understood. GDF15 expression was analyzed by RT-qPCR and western blotting assays in leukemic cells. enhancing antibody neutralization tests vitro were employed evaluate effect on...
Background:The aim of this study was to identify the incidence endolymphatic hydrops using 3-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging (MRI) in contralateral ear patients with unilateral Ménière’s disease (MD). Material andMethods:This a prospective study. 3D-FLAIR MRI performed 3 Tesla (3 T) unit 24 h after intratympanic administration gadolinium (Gd) 30 MD an asymptomatic ear. The involvement and potential correlations between affected ears were...
A PEGS/β-TCP composite membrane was fabricated by a simple prepolymer mixing-<italic>in situ</italic> crosslinking method for guided bone regeneration.
Abstract Adenotonsillar regrowth in children after adenotonsillectomy (T&A) for obstructive sleep apnea (OSA) is often seen clinical treatment, however, the relationship between allergic disease and adenotonsillar remains unclear. In this retrospective study, were assigned to either recurrence or control group, subdivided by age at operation. Among over 36 months, those group had more higher IgE, IL-4, IL-5 levels than same-aged group. The Paediatric Allergic Disease Quality of Life...
Venous thromboembolism (VTE) is a major cause of morbidity and mortality in gynecologic malignant patients after surgery. We aimed to validate the Caprini risk assessment model (RAM) elevated tumor-specific D-dimer as predictive marker postoperative VTE for undergoing surgery malignancies.Inpatients were divided into five groups (low: score = 0-1; moderate: 2; high: 3-4; higher: 5-7; sup-high: > 7) treated according their level during hospitalization RAM. was detected perioperative period....
Remodeling of adipocyte morphology and function plays a critical role in prostate cancer development. We previously reported that leukemia cells secrete growth differentiation factor 15 (GDF15)，which remodels the residual bone marrow (BM) adipocytes into small is associated with poor prognosis acute myeloid (AML) patients. However, little known about how GDF15 drives BM remodeling. In this study, we examined transient receptor potential vanilloid (TRPV) channels remodeling exposed to GDF15....
Apart from their role as antigen presenting cells, human peripheral blood monocyte and CD34+ cell‐derived dendritic cells (DC), have been demonstrated to exert cytotoxicity against some tumor tumoricidal activity can be enhanced by stimili. However, there no reports concerning the of cord (CBDC). In this article, we report that monocyte‐derived DC acquire ability kill hematological after activation with lipopolysaccharide (LPS) or γ‐interferon (IFN‐γ), associated TNF‐α‐related...