A5004921007- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Ovarian cancer diagnosis and treatment
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Gut microbiota and health
Shanxi Medical University
2020-2024
Shaanxi Provincial People's Hospital
2024
Shanxi Province Hospital of Traditional Chinese Medicine
2011
Shanghai Jiao Tong University
2009
Renji Hospital
2009
<p indent="0mm">This study investigates the role of lactate in genesis and progression ovarian cancer (OV) explores underlying mechanisms. Serum levels show a positive correlation with tumor grade poor prognosis patients OV. Bioinformatics analysis identifies <italic>CCL18</italic> as lactate-related gene CCL18 is up-regulated cancerous tissues positively related to serum OV patients. THP-1 cells are exposed phorbol-12-myristate-13-acetate for M0 macrophage induction. The results RT-qPCR...
Abstract Background The indoleamine 2, 3-dioxygenase (IDO) inhibitor 1-methyl-tryptophan (1-MT) is currently being used in clinical trials patients with relapsed or refractory solid tumors by inhibiting tumor immune escape. A greater understanding of IDO activity required to begin understand the molecular mechanism which drugs work. This study was conducted investigate significance treating carboplatin-resistant (CBP-resistant) ovarian cancer and its action. Methods Using a medium dose,...
Abstract Background Recent studies have provided evidence supporting the functional role and mechanism of lactate in suppressing anticancer immunity. However, there is no systematic analysis metabolism-related genes (LMRGs) ovarian cancer (OV) prognosis. Results Six (CCL18, CCND1, MXRA5, NRBP2, OLFML2B THY1) were selected as prognostic a model was utilized. Kaplan-Meier (K-M) Receiver Operating Characteristic (ROC) analyses further performed indicated that effective. Subsequently,...
Objective To explore immunotherapy effective combined with active in different time according rats bearing-tumor after paclitaxel and carboplatin chemotherapy, to identify the optimization strategy of vaccine seek rational chemo-immunotherapy strategies ovarian cancer treatment. Methods The dynamic immunocytes number function established tumor treated chemotherapy were investigated. changes volume immune groups observed combining vaccine. Results Lymphopenia was lymphocyte subset decreased...
Objective To investigate the changes of Tc1/Tc2 profiles and cytotoxic function CD8+ cells in ovarian cancer patients undergoing paclitaxel carboplatin chemotherapy, so as to identify whether there is a window period anti-tumor immune suppression reverse after chemotherapy. Methods Blood samples from each patient were obtained before (S0) at day 5-7 (S1), 12-14 (S2) 25-28 (S3) chemotherapy 13 patients. Thirteen age-matched healthy female volunteers enrolled control group. Flow cytometry...
Abstract Background: Ovarian cancer is one of the deadliest and most common gynecological malignancies. This study aims to use comprehensive bioinformatics analysis try identify core candidate genes related prediction ovarian for early diagnosis prognosis cancer. Methods: Obtain expression profiles from Gene Expression Omnibus database, differentially expressed (DEG) with p<0.05 (logFC)>1.5, perform functional enrichment, protein-protein interaction (PPI) network construction, module...