A5085403337- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Photosynthetic Processes and Mechanisms
- Plant Reproductive Biology
- Plant tissue culture and regeneration
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Plant Molecular Biology Research
- Metabolomics and Mass Spectrometry Studies
- Trace Elements in Health
- Gut microbiota and health
- Pediatric Hepatobiliary Diseases and Treatments
- Adipose Tissue and Metabolism
- Liver Disease and Transplantation
- Adipokines, Inflammation, and Metabolic Diseases
- Aquaculture disease management and microbiota
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Silymarin and Mushroom Poisoning
- Stress Responses and Cortisol
- Analytical Chemistry and Chromatography
- Tryptophan and brain disorders
- Bariatric Surgery and Outcomes
Qilu Hospital of Shandong University
2017-2025
Guangzhou Medical University
2025
State Key Laboratory for Innovation and Transformation of Luobing Theory
2025
University of Louisville
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Nanjing University
2024
State Key Laboratory of Pollution Control and Resource Reuse
2024
Sun Yat-sen University
2013-2024
Sun Yat-sen University Cancer Center
2024
Takeda (United States)
2024
Abstract Background Complex perianal fistulas are a serious complication in patients with Crohn’s disease (CD). Darvadstrocel (DVS), suspension of expanded adult allogeneic adipose-derived mesenchymal stem cells, is approved Europe and Japan for treatment complex (CPF). The global ADMIRE-CD II phase 3 randomized double-blind placebo-controlled study evaluated the efficacy safety DVS CPF. Methods Patients aged 18–75 years clinically controlled, inactive or mildly active CD CPF (≤2 internal...
Accumulated evidence has demonstrated that both oxidative stress and abnormal cytokine production, especially tumor necrosis factor-alpha (TNF), play important etiological roles in the pathogenesis of alcoholic liver disease (ALD). Agents have antioxidant anti-inflammation properties, particularly anti-TNF represent promising therapeutic interventions for ALD. We investigated effects possible mechanism(s) silymarin on injury induced by acute ethanol (EtOH) administration.Nine-week-old mice...
Background/Aims: Adipocyte-derived exosomes (ADEs) stimulate the activation of macrophages and contribute to development insulin resistance. Sonic Hedgehog (Shh) is an exosome-carrying protein stimulates secrete inflammatory cytokines. However, impact ADEs carrying Shh on pro-inflammatory consequently, adipocyte resistance unclear. Methods: 3T3-L1 adipocytes were cultured with high glucose imitate pathogeny isolated from conditioned media via differential ultracentrifugation. We explored...
Although simple steatosis was originally thought to be a pathologically inert histological change, fat accumulation in the liver may play critical role not only disease initiation, but also progression nonalcoholic steatohepatitis and cirrhosis. Therefore, prevention of an effective therapy for multiple stages fatty (NAFLD). Promising beneficial effects betaine supplementation on human NAFLD have been reported some pilot clinical studies; however, data related are limited. In this study, we...
In preclinical studies of fructose-induced NAFLD, endotoxin appears to play an important role. We retrospectively examined samples from three pediatric cohorts (1) investigate whether endotoxemia is associated with the presence hepatic steatosis; (2) evaluate postprandial levels in response fructose beverage acute 24-hour feeding challenge, and (3) determine change fasting amounts a 4-week randomized controlled trial comparing glucose beverages NAFLD. found that adolescents steatosis had...
Polychlorinated biphenyls (PCBs) are environmental pollutants associated with non-alcoholic-steatohepatitis (NASH), diabetes, and obesity. We previously demonstrated that the PCB mixture, Aroclor 1260, induced steatohepatitis activated nuclear receptors in a diet-induced obesity mouse model. This study aims to evaluate interactions pregnane-xenobiotic receptor (Pxr: Nr1i2) constitutive androstane (Car: Nr1i3) NASH. Wild type C57Bl/6 (WT), Pxr−/− Car−/− mice were fed high fat diet (42% milk...
Abstract Site‐specific recognition modules with DNA nuclease have tremendous potential as molecular tools for genome targeting. The type III transcription activator‐like effectors (TALEs) contain a binding domain consisting of tandem repeats that can be engineered to bind user‐defined specific sequences. We demonstrated customized TALE‐based nucleases (TALENs), constructed using method called “unit assembly”, specifically target the endogenous FRIGIDA gene in Brassica oleracea L. var....
Dietary copper-fructose interactions contribute to the development of nonalcoholic fatty liver disease (NAFLD). Gut microbiota play critical roles in pathogenesis NAFLD. The aim this study was determine effect different dietary doses copper and their with high fructose on gut microbiome. Male weanling Sprague-Dawley rats were fed diets adequate (6 ppm CuA), marginal (1.5 CuM) (low copper), or supplemented (20 CuS) (high copper) for 4 wk. Deionized water deionized containing 30% (wt/vol)...
We report a reverse phase chromatography mass spectrometry (LC-MS) method for simultaneous quantification of nucleosides and nucleotides from biological samples, where compound identification was achieved by tier-wise approach via external calibration. A total 65 authentic standards were used the platform development. The limit detection (LOD) those compounds ranged 0.05 nmol/L to 1.25 μmol/L, their (LOQ) 0.10 2.50 μmol/L. Using developed method, human plasma, urine, rat liver quantified....
Abstract Background Exercise rehabilitation is demonstrated to improve the prognosis of patients with coronary heart disease (CHD). Statins, as key medicine lower cholesterol in CHD, result skeletal muscle injury and impair exercise training adaptation. Energy metabolism dysfunction identified potential mechanism underlying statin‐induced injury. In this study, we investigated effects metabolic modulator trimetazidine on energy statin‐associated intolerance. Methods High‐fat fed...
Diversity analysis and taxonomic profiles can be generated from marker-gene sequence data with the help of many available computational tools. The Quantitative Insights into Microbial Ecology Version 2 (QIIME2) has been widely used for 16S rRNA analysis. While articles have demonstrated use QIIME2 suitable datasets, application to pre-clinical rarely talked about. issues involved in include low-quality score small sample size that should addressed properly during In addition, there are few...
Cryptogenic stroke constitutes approximately 40% of ischemic strokes in young adults, imposing a significant socioeconomic burden. However, the source embolus has been specifically investigated few number studies. In this report, We document first case cryptogenic associated with pulmonary arteriovenous fistula (PAVF), providing evidence mural thrombus formation within PAVF vessel. A 52-year-old woman present sudden-onset blurriness, right-sided numbness and paresthesia, speech difficulties,...
Background Heavy alcohol consumption frequently causes liver inflammation/injury, and certain fatty acids ( FAs ) may be involved in this pathology. In study, we evaluated the association of heavy drinking changes FA levels ω‐6 (pro‐inflammatory) ω‐3 (anti‐inflammatory) state alcohol‐dependent AD patients who had no clinical manifestations injury. We aimed to identify sex‐based differences with mild or biochemical evidence injury induced by drinking. Methods A total 114 female male aged 21...
Obesity and the metabolic syndrome occur in approximately one-third of patients with alcoholic liver disease (ALD). The increased consumption fructose parallels prevalence obesity United States worldwide. In this study, we investigated whether dietary high potentiates chronic alcohol-induced injury, explored potential mechanism(s).Six-week-old male C57BL/6J mice were assigned to 4 groups: control, fructose, ethanol (EtOH), plus alcohol. fed either control diet or high-fructose (60%, w/w) for...
Astrocytes in the hippocampus are immediately relevant to depressive-like behavior. By regulating their activities, Xiaoyaosan (XYS), a traditional Chinese medicine compound, works treatment of depression.Chronic unpredictable mild stress (CUMS) rat model was established observe regulation XYS. We investigated behavioral changes CUMS, expression corticosterone (CORT) hypothalamo-pituitary-adrenal (HPA) axis, Glu-NMDA receptor and astrocytes glial fibrillary acidic protein (GFAP) hippocampus....
Low serum testosterone level is associated with aging-related vascular stiffness, but the underlying mechanism unclear. The Growth arrest-specific protein 6 (Gas6) /Axl pathway has been proved to play important roles in cell senescence. In this study, we intend explore whether Gas6/Axl involved effect of on aging amelioration. Vascular models wild type and Axl-/- mice were established by natural aging. Mice these two gene types randomized into young group, group undecanoate (TU) treatment...
Abstract Congenital heart disease (CHD) is a structural abnormality of the and/or great vessels and patients with CHD are at an increased risks various morbidities throughout their lives reduced long‐term survival. Eventually, may result in complications including failure, arrhythmias, stroke, pneumonia, sudden death. Unfortunately, exact etiology pathophysiology some remain unclear. Although quality life prognosis have significantly improved following technological advancement, influence...