A5022826484- Cerebrovascular and Carotid Artery Diseases
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Inflammatory Biomarkers in Disease Prognosis
- RNA Interference and Gene Delivery
- Neurological Disease Mechanisms and Treatments
- Peroxisome Proliferator-Activated Receptors
- Circular RNAs in diseases
- Adenosine and Purinergic Signaling
- Drug Transport and Resistance Mechanisms
- Cerebral Venous Sinus Thrombosis
- Neuropeptides and Animal Physiology
- Fetal and Pediatric Neurological Disorders
- Nutritional Studies and Diet
- Renin-Angiotensin System Studies
- Tea Polyphenols and Effects
- Artificial Intelligence in Healthcare
- Vascular Malformations Diagnosis and Treatment
Second Affiliated Hospital of Xi'an Jiaotong University
2011-2025
Xi'an Jiaotong University
2011-2015
Abstract Objectives Life's essential 8 (LE8) is an emerging approach for accessing and quantifying cardiovascular health (CVH), but the effect on Parkinson's disease (PD) still unclear. This study aimed to elucidate association between LE8 metrics PD in US adults. Methods Data of 26,975 participants were extracted from last 7 National Health Nutrition Examination Survey (NHANES) cycles (2005–2018). The calculated according American Heart Association criterion, divided into 3 groups using...
Ischemic stroke (IS) is a principal contributor to long-term disability in adults. A new cell death mediated by iron ferroptosis, characterized lethal aggregation of lipid peroxidation. However, paucity ferroptosis-related biomarkers early identify IS until now. This study investigated potential gene pair and explored their roles immune infiltration.In total, we identified 6 differentially expressed genes (DEFRGs) the metadata cohort. Of these genes, 4 DEFRGs were incorporated into...
Abstract Background Screening carotid B-mode ultrasonography is a frequently used method to detect subjects with atherosclerosis (CAS). Due the asymptomatic progression of most CAS patients, early identification challenging for clinicians, and it may trigger ischemic stroke. Recently, machine learning has shown strong ability classify data potential prediction in medical field. The combined use electronic health records patients could provide clinicians more convenient precise identify CAS....
Oxidative stress (OS) and immune inflammation play complex intersections in the pathophysiology of ischemic stroke (IS). However, a competing endogenous RNA- (ceRNA-) based mechanism linked to IS has not been explored. We aimed identify potential OS-related signatures analyze infiltration characteristics IS. Three datasets (GSE22255, GSE110993, GSE140275) from GEO database were extracted. Differentially expressed long noncoding RNAs, microRNAs, messenger RNAs (DElncRNAs, DEmiRNAs, DEmRNAs)...
Edaravone Dexborneol (EDB), comprised of edaravone and (+)- bornel, has been demonstrated to have synergistic effects antioxidant anti-inflammatory, which makes it be applied for stroke as a protectant. However, the underlying mechanism neuroprotection EDB not fully elucidated. Increasing evidence shown that neurotoxic A1 astrocytes were closely related neuronal death after cerebral ischemia. whether could provide by modulating activation yet The present study aimed explore afforded...
Shunt dependence syndrome is a serious long-term complication characterized by symptoms and signs of increased intracranial pressure with normal-sized lateral ventricles after several years arachnoid cyst-peritoneal shunting. It easy to misdiagnose overlook when combined sinus stenosis, thus delaying treatment. Here, we present 35-year-old man an unexplained headache binocular horizontal diplopia high pressure. Based on stenosis the right transverse absent filling left found cerebral...
To investigate the clinical efficacy and safety of intravenous thrombolysis in patients with acute severe cerebral infarction analyze risk factors poor prognosis after thrombolysis.This randomized controlled trial was conducted among 152 infarction, onset time all within 4.5 h. The were into control group (76 cases) observation received treatment routine therapy (antiplatelet aggregation, statins, neuroprotection drugs that stimulate blood flow) thrombolytic alteplase addition to therapy,...
To investigate the expression of inflammatory molecule CD40 in pallium and hippocampus rats after status epilepticus (SE). The pallium, different areas cells from lithium-pilocarpine epileptic at time points were examined by immunohistochemistry double-immunofluorescent labeling. After SE, was obviously inhibited, especially hippocampus. mainly expressed activated microglia. positive reached a peak 3rd day returned to slightly higher level 7th SE compared with before SE. Elevation microglia...