A5068712005- Meningioma and schwannoma management
- Facial Nerve Paralysis Treatment and Research
- Hearing, Cochlea, Tinnitus, Genetics
- PARP inhibition in cancer therapy
- Erythropoietin and Anemia Treatment
- Hearing Loss and Rehabilitation
- Head and Neck Surgical Oncology
- Neurofibromatosis and Schwannoma Cases
- Ear Surgery and Otitis Media
- Congenital heart defects research
- Neurogenesis and neuroplasticity mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Ear and Head Tumors
- Vestibular and auditory disorders
- Advanced biosensing and bioanalysis techniques
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Nuclear and radioactivity studies
- Congenital Ear and Nasal Anomalies
- Vascular Malformations Diagnosis and Treatment
- Organic Light-Emitting Diodes Research
- Seed and Plant Biochemistry
- Phytochemicals and Medicinal Plants
Fudan University
2013-2023
Zhongshan Hospital
2023
Songshan Lake Materials Laboratory
2023
Eye & ENT Hospital of Fudan University
2011-2022
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2022
Shanghai Medical Information Center
2021
Affiliated Hospital of Hebei University
2020
Shanghai Clinical Research Center
2018
Huzhou University
2017-2018
Baylor College of Medicine
2017
Abstract Fluorescent analysis of bone provides valuable insights into structures. However, conventional dyes suffer from low specificity on tissue, small stokes shift, short fluorescent lifetime, and aggregation‐caused quenching effect, which result in efficacy artifacts. In this work, we design an aggregation‐induced emission (AIE)‐active iridium(III) complex ( Ir‐BP2 ) as a highly selective, convenient, nondestructiveness, dual‐mode staining agent for analysis. containing phosphonate...
Oxidative stress-induced neuronal apoptosis plays an important role in the progression of central nervous system (CNS) diseases. In our study, when cells were exposed to hydrogen peroxide (H2O2), exogenous oxidant, cell was observed with typical morphological changes including membrane blebbing, neurite retraction and contraction. The actomyosin is considered be responsible for changes, but how exactly it regulates oxidative distinctive functions different myosin II isoforms remain unclear....
Objectives: Our research investigated the relationship between childhood leukemia and breastfeeding in P. R. of China.Methods: We conducted a retrospective case-control study from March 2008 to April 2017 at Children’s Hospital Zhejiang University, province, China, which reviewed 958 children who had been diagnosed with case group 785 healthy control group. Data were obtained medical records, if records incomplete, we called mothers by phone complete data.Results: Breastfeeding reduces risk...
Embryonic neural stem cells (NSCs) were isolated from the neuroepithelium of dorsal telencephalon embryonic rats and infected by Ad5-Atoh1-enhanced green fluorescent protein. These NSCs then delivered into neurosphere culture medium or transplanted endolymphatic space normal guinea pig cochlea through cochleostomy. NSC phenotype these was determined immunohistochemical detection cell-specific protein markers. Survival, location hair cell (HC) differentiation implanted expression report gene,...
Since little has been reported about complications of spinal anesthesia in adult tethered cord syndrome (TCS), we sought to delineate the characteristics condition. A total 4 cases TCS after were reviewed. The medical charts patients obtained. Anesthesia, which was combined and epidural or performed, follow-up carried out all patients. most common neurological symptom before surgery occasional severe pain back, perineal region, legs. Frequent micturition, diminished knee ankle reflexes,...
Embelin is a small-molecule inhibitor extracted from plants of the Myrsinaceae family demonstrating specific inhibition X-linked apoptosis protein (XIAP) to affect proliferation and various types tumor cells. However, mechanism action for this effect remains unclear. The purpose present study was investigate role mitochondrial pathway in embelin-induced HepG2 human hepatocellular carcinoma cell embelin on cycle. cells were treated with different doses embelin. MTT method used determine...
Background: Petrous bone cholesteatoma (PBC) is a rare but local aggressive lesion which can lead to severe complications. Surgery the mainstay for its treatment.Objectives: To analyse clinical characteristics and surgical outcomes in series of patients with PBC, paying special attention cochlea preservation use endoscope.Materials methods: Retrospective study 51 PBC who underwent surgery at our centre.Results: Hearing loss (72.5%) facial paralysis (58.8%) were two most common symptoms....
The Numb and Numb-like are evolutionarily conserved cell fate-determining factors in mammals. For the first time, we investigate involvement of developing auditory sensory epithelium. We show that both them expressed rat epithelium, four isoforms have dynamic expression patterns during cochlear development. At early stage epithelium development, they occur all progenitor cells. late differentiation, mainly cytoplasm apical cells their locations different. Furthermore, find overexpression or...
Objective Anatomic knowledge is needed to avoid injury internal carotid artery (ICA) during the endoscopic surgery around nasopharynx and its surrounding space. Design We prospectively studied computed tomography angiography (CTA) data of 28 patients with image processing software. Special attention was given ICA various landmarks nasopharynx. Results The anatomic relationship between different clearly presented in three-dimension. fossa Rosenmuller nearest point nasopharyngeal cavity ICA....
Abstract Although there have been significant advances in cancer treatment, the urgent need to inhibit breast metastasis remained unmet. Bruceine A (BA) is a natural compound extracted from Bruceae Fructus and has long recognized antitumor effects with high safety biocompatibility. However, mechanisms and/or targets of BA for metastatic treatment are still not fully elucidated. In this study, we systematically investigated on inhibition its underlying mechanisms. We found that, addition...
Hair cell regeneration is the fundamental method of correcting hearing loss and balance disorders caused by hair damage or loss. How to promote a hot focus in current research. In mammals, cochlear cells cannot be regenerated few vestibular can renewed through spontaneous regeneration. However, Math1 gene transfer allows inner ear transformed into vitro vivo. two possible means birds: supporting differentiation transdifferentiation with without division. strongly associated proliferation....
Previous studies have found that recombinant human erythropoietin (rhEPO) protects long-term cultured ageing primary nerve cells by enhancing the endogenous antioxidant capacity of cells; however, its signalling pathways are not clear. This study aimed to explore relationship between rhEPO and PI3K/Akt in protection senescent at cellular level.Primary were for 22 days mimic natural process cells. LY294002 administered as an intervention on 11th day culture. Western blot, immunochemistry,...
Bypass reconstructed from the cervical segment of internal carotid artery (ICA) to its petrous allows high-volume bypass flow without any risk intracranial dissection. The purpose this study was investigate geometric effect on end-to-side anastomosis cervical-to-petrous bypass, for close relationship local haemodynamic and long-term performance bypass. We focused two controllable parameters: diameter ratio (Φ) angle (α) between graft host arteries. Different models covering a range Φ (0.75,...
Abstract In vitro cell experiments have suggested that recombinant human erythropoietin (rhEPO) and peroxisome proliferator activated receptor γ (PPARγ) activation exert protective effects on neurons. This study observed the learning memory ability, antioxidant capacity ratio of apoptotic cells after rhEPO intervention investigated relationship among rhEPO, PI3K/Akt PPARγ in anti‐neural oxidative stress injury process vivo. The results showed significantly improved abilities rats subjected...