A5056864536- Ultrasonics and Acoustic Wave Propagation
- Acoustic Wave Resonator Technologies
- Ultrasound Imaging and Elastography
- Alzheimer's disease research and treatments
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Advanced Glycation End Products research
- Heme Oxygenase-1 and Carbon Monoxide
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Physiological and biochemical adaptations
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Advanced MEMS and NEMS Technologies
- Flow Measurement and Analysis
- Cancer-related molecular mechanisms research
- Neurobiology and Insect Physiology Research
- Garlic and Onion Studies
- Speech and Audio Processing
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
Second Xiangya Hospital of Central South University
2022-2025
Central South University
2022-2025
Wuhan University
2021-2024
Wuhan University of Technology
2021-2024
Huzhou University
2014-2024
Huzhou Central Hospital
2024
Soil and Fertilizer Institute of Hunan Province
2022-2023
Civil Aviation Flight University of China
2023
Nanfang Hospital
2018-2022
Southern Medical University
2018-2022
Acute kidney injury (AKI) is a common clinical problem, and patients who survive AKI have high risk of chronic disease (CKD). The mechanism CKD post-AKI, characterized by progressive renal fibrosis, still unclear. Maladaptive tubular epithelial cells (TECs) after are considered leading cause fibrosis post-AKI. TECs under maladaptive repair manifest characteristics senescence. Removing senescent genetic ablation has been proven effective in reducing fibrosis. Senolytics, which eliminate...
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and an important cause end-stage renal disease (ESRD). However, there still lack effective prevention treatment strategies in clinical practice. As metabolic disease, DN accompanied by ectopic lipid deposition, the deposited lipids further aggravate kidney injury. molecular mechanism deposition currently unknown. In this study, we observed changes droplet (LD)–mitochondria connections for first time. Destruction...
In this article, we present a high-performance aluminum nitride (AlN)-based microelectromechanical system (MEMS) hydrophone sensor, in which the sensing cells are designed and arranged as an innovative honeycomb architecture for achieving large acoustic pressure sensitivity high fill-factor. An 8×9 array of 360 μm characteristic size, 0.92-MHz MEMS sensor is developed based on AlN-on-cavity silicon-on-insulator (CSOI) platform. The size 3.2 mm ×3.2 mm. its preamplification circuit integrated...
ABSTRACT Renal proximal tubular epithelial cell (PTEC) senescence and defective autophagy contribute to kidney aging, but the mechanisms remain unclear. Caveolin‐1 (CAV1), a crucial component of membrane caveolae, regulates is associated with cellular senescence. However, its specific role in aging poorly understood. In this study, we generated Cav1 gene knockout mice induced using D‐galactose (D‐gal). The results showed that CAV1 expression increased renal cortex mice, which was accompanied...
In recent years, the roles of mitochondrial RNA and its associated human diseases have been reported to increase significantly. Treatments based on mtRNA metabolic processes nuclear gene mutations are thus discussed. The oxidative phosphorylation process is affected by metabolism, including production, maturation, stabilization, degradation, which leads a variety inherited diseases. Moreover, caused messenger RNA, transfer ribosomal mutations. This review presents molecular mechanisms...
Acute kidney injury (AKI) is characterized by necroinflammation formed necrotic tubular epithelial cells (TECs) and interstitial inflammation. In necroinflammation, macrophages are key inflammatory can be activated polarized into proinflammatory macrophages. Membranous Toll-like receptors (TLRs) cooperate with intracellular NOD-like receptor protein 3 (NLRP3) to recognize danger signals from TECs activate assembling NLRP3 inflammasome. However, the cooperation between TLRs still unclear....
Peroxisomes are metabolically active organelles that known for exerting oxidative metabolism, but the precise mechanism remains unclear in diabetic nephropathy (DN). Here, we used proteomics to uncover a correlation between antioxidant protein disulfide-bond A oxidoreductase-like (DsbA-L) and peroxisomal function. In vivo, renal tubular injury, stress, cell apoptosis high-fat diet plus streptozotocin (STZ)-induced mice were significantly increased, these changes accompanied by "ghost"...
This article investigates the dependence of transmitting sensitivity on top electrode design piezoelectric micromachined ultrasonic transducers (PMUTs). Two typical electrodes, namely inner (IE) and outer (OE), are designed fabricated. The measured velocities fabricated PMUTs at resonance under a drive voltage 5 [Formula: see text] (peak-to-peak) 15.36 mm/s for IE 20.67 OE with circular diaphragm 16.62 22.18 hexagonal diaphragm. demonstrates velocity improvement 34.57% 33.45% is due to fact...
A piezoelectric micromachined ultrasonic transducer (PMUT) array-based smart electronic stethoscope is presented for Internet of Medical Things (IoMT). For the first time, an based on a high-performance PMUT array demonstrated to record mechanoacoustic cardiopulmonary signals from body. This can continuously capture and enable telemedicine as well digital medical becoming reality. The measured are collected using transmitted mobile terminal via Bluetooth. Then, primary diagnosis be...
One of the most important performance metrics for piezoelectric micromachined ultrasonic transducers (PMUTs) is their transmitting sensitivity, which significantly dependent on design transduction diaphragm. In this work, a comprehensive comparison transmission sensitivities PMUTs with circular, square, and hexagonal diaphragms are investigated through theoretical calculations, finite element analysis (FEA), as well experimental verifications. Compared to circular square diaphragms,...
Neuroinflammation characterized by glial activation and release of proinflammatory mediators is considered to be correlated with cognitive deficits in Alzheimer's disease (AD). Previously, some studies have demonstrated that lycopene (LYCO) or human amniotic epithelial cells (HAECs) could attenuate inflammation AD. Specifically, the choroid plexus (CP), an layer forms blood-cerebrospinal fluid barrier, able modulate function, through changes neuroinflammatory response brain immune...
Abstract Mitochondria-associated endoplasmic reticulum membranes (MAMs) regulate ATG14- and Beclin1-mediated mitophagy play key roles in the development of diabetic nephropathy (DN). DsbA-L is mainly located MAMs plays a role renoprotection, but whether it activates by maintaining MAM integrity remains unclear. In present study, we found that renal tubular damage was further aggravated DsbA-L−/− mice compared with this accompanied disrupted decreased mitophagy. Furthermore, notably...
Objectives: Our research investigated the relationship between childhood leukemia and breastfeeding in P. R. of China.Methods: We conducted a retrospective case-control study from March 2008 to April 2017 at Children’s Hospital Zhejiang University, province, China, which reviewed 958 children who had been diagnosed with case group 785 healthy control group. Data were obtained medical records, if records incomplete, we called mothers by phone complete data.Results: Breastfeeding reduces risk...