A5101661152- Autophagy in Disease and Therapy
- Fungal Biology and Applications
- Biomedical Research and Pathophysiology
- Mitochondrial Function and Pathology
- Renal Diseases and Glomerulopathies
- Genetic and Kidney Cyst Diseases
- Advanced Glycation End Products research
- Endoplasmic Reticulum Stress and Disease
- Bacterial Infections and Vaccines
- Nutrition and Health in Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Virology and Viral Diseases
- Pancreatic function and diabetes
- Cytokine Signaling Pathways and Interactions
- Peroxisome Proliferator-Activated Receptors
- Heme Oxygenase-1 and Carbon Monoxide
- Chronic Kidney Disease and Diabetes
- GDF15 and Related Biomarkers
- Cancer-related molecular mechanisms research
- Alcohol Consumption and Health Effects
- Phytochemicals and Antioxidant Activities
- Animal Virus Infections Studies
- Nuclear Receptors and Signaling
- Chromatography in Natural Products
- Nanocluster Synthesis and Applications
Second Xiangya Hospital of Central South University
2020-2025
Central South University
2020-2025
Soil and Fertilizer Institute of Hunan Province
2023
Jiangxi Agricultural University
2023
Peking Union Medical College Hospital
2021
Fujian Medical University
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Guangzhou University of Chinese Medicine
2019
National Institutes for Food and Drug Control
2019
Huazhong University of Science and Technology
2016
Mitochondria-associated endoplasmic reticulum membrane (MAM) may have a role in tubular injury diabetic nephropathy (DN), but the precise mechanism remains unclear. Here, we demonstrate that expression of phosphofurin acidic cluster sorting protein 2 (PACS-2), critical regulator MAM formation, is significantly decreased renal tubules patients with DN, and PACS-2 positively correlated function negatively degrees tubulointerstitial lesions. Conditional deletion Pacs-2 proximal (PTs) aggravates...
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and an important cause end-stage renal disease (ESRD). However, there still lack effective prevention treatment strategies in clinical practice. As metabolic disease, DN accompanied by ectopic lipid deposition, the deposited lipids further aggravate kidney injury. molecular mechanism deposition currently unknown. In this study, we observed changes droplet (LD)–mitochondria connections for first time. Destruction...
Peroxisomes are metabolically active organelles that known for exerting oxidative metabolism, but the precise mechanism remains unclear in diabetic nephropathy (DN). Here, we used proteomics to uncover a correlation between antioxidant protein disulfide-bond A oxidoreductase-like (DsbA-L) and peroxisomal function. In vivo, renal tubular injury, stress, cell apoptosis high-fat diet plus streptozotocin (STZ)-induced mice were significantly increased, these changes accompanied by "ghost"...
Mitochondria are the energy factories of cells, and their functions closely related to cell homeostasis. The mitochondrial unfolded protein response (mtUPR) is a newly discovered mechanism for regulating When unfolded/misfolded proteins accumulate in mitochondria, mitochondria release signals that regulate transcription certain nucleus, thereby inducing correct folding or degradation mitochondria. Many studies have also shown an abnormality mtUPR occurrence development diseases. Here, we...
Purpose: Evidence of the impact nutritional risk on health outcomes and hospital costs among Chinese older inpatients is limited. Relatively few studies have investigated association between clinical cost in immobile inpatients, particularly those with neoplasms, injury, digestive, cardiac, respiratory conditions. Methods: This China-wide prospective observational cohort study comprised 5,386 hospitalized at 25 hospitals. All patients were screened for using Nutrition Risk Screening (NRS...
This study aimed to explore the feasibility of pneumococcal surface protein A (PspA) as a carrier protein. Three recombinant proteins from three different clades were expressed by prokaryotic expression system and conjugated group meningococcal polysaccharide (GAMP) generate polysaccharide-protein conjugates. The conjugates, unconjugated proteins, GAMP, GAMP-TT vaccine bulk (used positive control) immunized into mice, their immune effects assessed methods enzyme-linked immunosorbent assay...
<a>Mitochondria-associated endoplasmic reticulum membrane (MAM) is emerging as a novel insight into tubular injury in diabetic nephropathy (DN), but the precise mechanism remains unclear. </a>Here, we demonstrate that expression of phosphofurin acidic cluster sorting protein 2 (PACS-2), critical regulator MAM formation, significantly decreased <a>renal tubules</a> patients with DN, which positively correlated renal function and negatively degrees tubulointerstitial...
<a>Mitochondria-associated endoplasmic reticulum membrane (MAM) is emerging as a novel insight into tubular injury in diabetic nephropathy (DN), but the precise mechanism remains unclear. </a>Here, we demonstrate that expression of phosphofurin acidic cluster sorting protein 2 (PACS-2), critical regulator MAM formation, significantly decreased <a>renal tubules</a> patients with DN, which positively correlated renal function and negatively degrees tubulointerstitial...