A5108285393- Hearing, Cochlea, Tinnitus, Genetics
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Acoustic Wave Phenomena Research
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Hormonal Regulation and Hypertension
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Lung Cancer Diagnosis and Treatment
- Plant biochemistry and biosynthesis
- Laser Applications in Dentistry and Medicine
- Blood Pressure and Hypertension Studies
- Inflammasome and immune disorders
- Ear Surgery and Otitis Media
- DNA Repair Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Sexual function and dysfunction studies
- Biomarkers in Disease Mechanisms
- Developmental Biology and Gene Regulation
- Calcium signaling and nucleotide metabolism
- Cell death mechanisms and regulation
- Genetic Associations and Epidemiology
- Sodium Intake and Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
Hypertension Institute
2025
People's Hospital of Xinjiang Uygur Autonomous Region
2025
Dalian Minzu University
2024
Binzhou University
2024
Binzhou Medical University
2024
Chengdu Research Base of Giant Panda Breeding
2024
Liaoning Cancer Hospital & Institute
2009-2024
China Medical University
2020-2024
Nanjing University
2024
Eye & ENT Hospital of Fudan University
2016-2024
Abstract Background Mesenchymal stem cells (MSCs) are pluripotent mesenchymal present in various adult tissues. MSCs secrete exosomes as regulators of the tumor niche, with involvement tumorigenesis and metastasis. The regulatory role microRNAs (miRs or miRNAs) via targeting cyclin E1 (CCNE1) E2 (CCNE2) has been extensively reported. Since considered protective enriched sources shuttle miRNAs, we hypothesized that exosomal transfer miR-144 from bone marrow-derived (BMMSCs) would affect...
Limited studies have examined the relationship between plasma aldosterone concentration (PAC) and arterial stiffness progression. This study aimed to investigate longitudinal association baseline PAC progression in hypertensive patients. was a conducted at Hypertension Center of People's Hospital Xinjiang Uygur Autonomous Region April 2020 October 2023. The included 1,138 patients who had completed two measurements brachial-ankle pulse wave velocity (baPWV) over period. Arterial quantified...
Objective: Hypertension development and progression are largely influenced by inflammation, which plays a critical role activating the immune system causing damage to vascular endothelium. Metabolic dysfunction-associated fatty liver disease (MAFLD) is also associated with chronic low-grade drives via metabolic imbalances adipose tissue dysfunction. This study investigates relationship between inflammatory indices MAFLD in hypertensive patients assesses predictive accuracy of these for...
The initial randomized, double-blinded, actively controlled, phase III ANEAS study (NCT03849768) demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer (NSCLC). Metastatic disease the central nervous system (CNS) remains a challenge management of NSCLC. This aimed compare versus among patients with baseline CNS metastases study.
Savolitinib has been found to have encouraging antitumor activity and a favorable safety profile in Chinese patients with pulmonary sarcomatoid carcinoma other NSCLCs MET exon 14 skipping alterations (MET ex14 positive) at the primary analysis of phase 2 study. Here, we present long-term efficacy data savolitinib, including subgroup analyses.This multicenter, single-arm, open-label, study People's Republic China enrolled inhibitor-naive adults locally advanced or metastatic METex14-positive...
Background: Previous studies have linked primary aldosteronism to simple renal cysts (SRC), but the relationship between plasma aldosterone concentration (PAC) and SRC remains unclear. This study aimed investigate association PAC in hypertensive patients. Methods: A total of 30,135 patients who visited our hospital from January 2014 December 2023 were included. Logistic regression analyses conducted explore SRC, while restricted cubic splines (RCS) assessed dose-response relationship....
Objectives To investigate the relationship between plasma aldosterone concentration (PAC) and prevalence of peripheral artery disease (PAD) in hypertensive patients to determine any potential threshold effects. Methods This cross-sectional study analyzed data from 13,157 individuals People's Hospital Xinjiang Uygur Autonomous Region, China. PAD was diagnosed based on an ankle-brachial index (ABI) ≤0.90. A multivariate logistic regression model utilized evaluate association PAC PAD, a...
Abstract Background Excision repair cross-complementing group 1 (ERCC1) and 2 (ERCC2), X-ray (XRCC1) proteins play important roles in the of DNA damage adducts. Single nucleotide polymorphisms (SNPs) genes are suspected to influence treatment effect survival cancer patients. This study aimed investigate relationship between ERCC2 , ERCC1 XRCC1 non-smoking female patients with lung adenocarcinoma. Methods We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
Background Before tyrosine kinase inhibitor (TKI) therapy can be administered in patients with advanced non‐small cell lung cancer (NSCLC), EGFR mutation testing is required. However, few studies have evaluated the extent of real‐world practice China. Methods A multicenter, observational study NSCLC North China was conducted. Treatment‐naïve or those postoperative recurrent stage IIIB/IV were enrolled. The primary objective rate. Secondary objectives included status, methods and specimens,...
Abstract Background Excision repair cross-complementing group 1 (ERCC1) and 2 (ERCC2) proteins play important roles in the of DNA damage adducts. Single nucleotide polymorphisms (SNPs) genes are suspected to influence risk lung cancer. This study aimed investigate association between ERCC2 751, 312 ERCC1 118 adenocarcinoma Chinese non-smoking females. Methods A hospital-based case-control 285 patients matched controls was conducted. Information concerning demographic factors obtained for...
Cardiac ischemia/reperfusion (I/R) injury has emerged as an important therapeutic target for ischemic heart disease. Currently, there is no effective therapy reducing cardiac I/R injury. Damage-associated molecular patterns are endogenous molecules released after cellular damage to exaggerate tissue inflammation and RIPK3 (receptor-interacting protein kinase 3), a well-established intracellular mediator of cell necroptosis inflammation, serves circulating biomarker multiple diseases....
Homeobox B7 (HOXB7) has been found to be overexpressed in numerous types of human cancer. However, the role HOXB7 breast cancer remains elucidated. The aim present study was investigate effects on proliferation and invasion cells. Initially, reverse transcription quantitative polymerase chain reaction western blotting were respectively employed detect mRNA protein expression levels gene MDA‑MB‑231 MCF‑7 cell lines. Subsequently, small interfering RNAs designed interfere with used knockdown...
Abstract Sensory hair cells are coordinately oriented within each inner ear sensory organ to exhibit a particular form of planar cell polarity (PCP) necessary for mechanotransduction. However, the developmental events associated with establishing PCP in vestibule unclear, hindering data interpretation and employment studies. Herein, we investigated mouse vestibular organs. We further characterised cycle exit, differentiation, establishment utricle. found that formed first striolar medial...
The use of immune checkpoint inhibitors including PD-1 and PD-L1 is recommended for the treatment previously untreated advanced non-small cell lung cancer (NSCLC) patients. immunohistochemical detection expression on tumor cells has emerged as most widely utilized biomarker in clinical practice. However, predictive value mutation burden (TMB) remains controversial. Here, we reported result two cohorts an umbrella trial, to evaluate efficacy safety sintilimab monotherapy NSCLC with ≥50%...
Intense noise poses a threat to spiral ganglion neurons (SGNs) in the inner ear, often resulting limited axonal regeneration during injury and leading noise-induced hearing loss (NIHL). Here, we propose an ultrasound-triggered nitric oxide (NO) release enhance sprouting of injured axons SGNs. We developed hollow silicon nanoparticles load nitrosylated N-acetylcysteine, producing HMSN-SNO, which effectively protects NO from external interferences. Utilizing low-intensity ultrasound...
Notch inhibition is known to generate supernumerary hair cells (HCs) at the expense of supporting (SCs) in mammalian inner ear. However, activity becomes progressively less effective inducing SC-to-HC conversion postnatal cochlea and balance organs as animal ages. It has been suggested that capacity inversely correlated with E-cadherin accumulation utricles. whether localization linked ear poorly understood. In present study, we treated cochleae from day 0 (P0) signaling inhibitor DAPT...
We aimed to investigate the beneficial effect of Celastrol on inner ear stem cells and potential therapeutic value for hearing loss. The were isolated characterized from utricular sensory epithelium adult mice. stemness was evaluated by sphere formation assay. relative expressions Atoh1, MAP-2 Myosin VI measured RT-PCR immunoblotting. up-regulation also analysed with immunofluorescence. in vitro neuronal excitability interrogated calcium oscillation. electrophysiological property determined...
Loss of hair cells from vestibular epithelium results in balance dysfunction. The current therapeutic regimen for diseases is limited. Upon injury or Atoh1 overexpression, cell replacement occurs rapidly the mammalian utricle, suggesting a promising approach to induce regeneration. In this study, we applied simultaneous gentamicin-mediated ablation and overexpression neonatal utricular formation vitro. We confirmed that type I were primary targets gentamicin. Furthermore, promoted...