A5101887181- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- RNA Research and Splicing
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Cancer Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Lung Cancer Treatments and Mutations
- 14-3-3 protein interactions
- Acute Myeloid Leukemia Research
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- Pharmacogenetics and Drug Metabolism
- Cancer, Lipids, and Metabolism
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
Shandong University
2013-2025
Hubei University of Chinese Medicine
2025
Sichuan Cancer Hospital
2017-2024
University of Electronic Science and Technology of China
2020-2024
Huazhong University of Science and Technology
2021
Sun Yat-sen University
2010-2021
The First Affiliated Hospital, Sun Yat-sen University
2010-2021
Youjiang Medical College for Nationalities
2020
Guangxi Center for Disease Prevention and Control
2020
Taian City Central Hospital
2020
Rheumatoid arthritis (RA) is an autoimmune disease which lack of effective therapies. Abnormal activation, proliferation, and differentiation T lymphocytes are closely related to RA. Mesenchymal stem cells (MSCs) can be used for RA treatment due their immunoregulatory effects. However, the specific molecular mechanisms have not been fully elucidated therapeutic effect has inconsistent. This study investigated immunomodulatory human umbilical cord MSCs (hUCMSCs) on in collagen-induced (CIA)...
Abstract CD147 plays a critical role in the invasive and metastatic activity of malignant melanoma cells by stimulating surrounding fibroblasts to express matrix metalloproteinases vascular endothelial growth factor. We developed system that blocks human cell line, A375, using RNA interference. By transfecting with small interfering (siRNA) targets CD147, we were able establish two stable clones which expression was significantly down-regulated. This resulted decreased proliferation invasion...
The initial randomized, double-blinded, actively controlled, phase III ANEAS study (NCT03849768) demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer (NSCLC). Metastatic disease the central nervous system (CNS) remains a challenge management of NSCLC. This aimed compare versus among patients with baseline CNS metastases study.
Abstract Breast cancer (BRCA) is the second leading cause of cancer‐related death among female worldwide. Recent studies have revealed that LACTB was frequently repressed and functioned as a bona fide new tumor suppressor in series cancers, including BRCA. However, molecular mechanisms underlying dysregulation BRCA not been reported. In present study, we find associated with poor prognosis by tissue microarray (TMA) analysis. Moreover, confirm direct target miR‐374a, which significantly...
Background: The administration of immune checkpoint inhibitors (ICIs) in advanced non-small cell lung cancer (NSCLC) with oncogenic driver alterations other than epidermal growth factor receptor (EGFR) aroused a heated discussion. We thus aimed to evaluate ICI treatment these patients real-world routine clinical practice. Methods: A multicenter, retrospective study was conducted for NSCLC at least one gene alteration (KRAS, HER2, BRAF, MET, RET, ALK, ROS1) receiving monotherapy or...
L3MBTL encodes a member of the Polycomb family proteins, which, together with Trithorax group is responsible for coordinated regulation patterns gene activity. Members also regulate self renewal normal and malignant hematopoietic stem cells. lies in region chromosome 20, deletion which associated myeloid malignancies represents good candidate 20q target gene. However, mutations have not been identified patients deletions or cytogenetically patients. Here we demonstrate that monoallelic...
We recently demonstrated that overexpression of HOTAIR (Hox transcript antisense intergenic RNA ) was associated with tumor progression and radio‐resistance in human cervical cancer. Considering the single nucleotide polymorphism ( SNP rs920778 (C>T) could influence expression cancer predisposition other malignancies, we herein investigated association between status susceptibility a Chinese population. Using specific TaqMan PCR assay, genotyped 215 patients 430 age‐matched healthy...
Abstract Introduction: Aumolertinib, a third generation selective EGFR-TKI, is standard of care for the first-line treatment in advanced or metastatic NSCLC with sensitizing EGFR mutations China. Evidence has shown that combining EGFR-TKIs chemotherapy can improve outcomes compared to monotherapy. AENEAS2 (NCT04923906) randomized, open-label, multicenter, phase 3 study assessing efficacy and safety aumolertinib plus versus alone as locally mutations. Methods: Patients who were naïve...
Long non-coding RNA (lncRNA) H19 is a hot spot in tumor development, progression and metastasis. This study assessed the association between genetic polymorphisms susceptibility of lung cancer.The case-control was conducted to evaluate four selected single nucleotide (rs217727, rs2107425, rs2735469 rs17658052) gene risk cancer. There were 556 female never smoking cancer patients 395 cancer-free controls. Unconditional logistic regression analysis used analyze associations SNPs risks by...
As a traditional Chinese medicine, Croton tiglium has the characteristics of laxative, analgesic, antibacterial and swelling. This study aimed to analyze chemical composition C. essential oil (CTEO) extracted from seeds its cytotoxicity antitumor effect in vitro. Supercritical CO2 fluid extraction technology was used extract CTEO constituents were identified by comparing retention indices mass spectra data taken NIST library with those calculated based on C7-C40 n-alkanes standard. In vitro...
Abstract Abnormal expression or activity of proteins that regulate cell polarity can contribute to tumour progression. Discs large homolog ( DLG ) play crucial roles in the maintenance and tissue morphogenesis. Previous studies breast cancer patients showed 3 had greater cancerous tissues than non‐cancerous tissues, but relationship between progression prognosis is not clear. Here, we investigated association with using data on clinicopathological parameters from The Cancer Genome Atlas TCGA...
CDKN1C and NAP1L4 in human CDKN1C/KCNQ1OT1 imprinted domain are two key candidate genes responsible for BWS (Beckwith-Wiedemann syndrome) cancer. In order to increase understanding of these pigs, their cDNAs characterized this paper. By the IMpRH panel, porcine were assigned chromosome 2, closely linked with IMpRH06175 LOD 15.78 17.94, respectively. real-time quantitative RT-PCR polymorphism-based method, tissue allelic expression both determined using F1 pigs Rongchang Landrace reciprocal...
Long noncoding RNAs (lncRNAs) are a new class of potential biomarkers and therapeutic targets for cancer. In this study, we chose four single nucleotide polymorphisms (SNPs) in lncRNA-PCAT1 (rs1026411 G>A, rs12543663 A>C, rs710886 T>C, rs16901904 T>C) to investigate the association between genetic variant susceptibility lung The study was hospital-based case-control including 561 cancer-free controls 468 cancer cases. Genotyping SNPs conducted by using Taqman® allelic discrimination methods....
The aim of the present study was to identify a child hepatoblastoma serum biomarker that is unaffected by inflammatory factors, with ultimate finding an effective method for early diagnosis hepatoblastoma. magnetic bead-based weak cation exchange chromatography technique used process harvested from 30 children hepatoblastoma, 20 systemic response syndrome (SIRS) and healthy children. Proteins differentially expressed in SIRS were excluded consideration as biomarkers controls screened using...
Growing evidence supports BH3-interacting domain death agonist (Bid) playing a dual role in DNA damage response. However, the effects of Bid on hepatocellular carcinoma (HCC) cell proliferation response to etoposide-induced have not been sufficiently investigated.Using stable Bid-overexpression HCC line, Bid/PLC/PRF/5, overexpression promoted loss viability damage. MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]- and BrdU (5'-bromo-2'-deoxyuridine)-labeling assays revealed...
This study aimed to explore the expression profile of Forkhead box protein L2 gene (FOXL2) and determine its prognostic value associated epigenetic genetic alterations in patients with laryngeal squamous cell carcinoma (LSCC).Data for a subset LSCC (N = 116) were extracted from head neck dataset The Cancer Genome Atlas analyzed relation FOXL2 survival.Aberrant was an independent factor progression-free survival (PFS) (hazard ratio (HR): 2.63, 95% confidence interval (CI): 1.34-5.18) overall...