A5100708615- Immune Response and Inflammation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Burn Injury Management and Outcomes
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Respiratory Support and Mechanisms
- Cancer Mechanisms and Therapy
- Thermal Regulation in Medicine
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sepsis Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Pharmacological Effects of Natural Compounds
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Wound Healing and Treatments
- Spinal Fractures and Fixation Techniques
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Neonatal Health and Biochemistry
- Spine and Intervertebral Disc Pathology
- Advanced Glycation End Products research
Jinan University
2025
Shandong First Medical University
2024
Anhui Medical University
2024
XinHua Hospital
2015-2024
Shanghai Jiao Tong University
2014-2024
Tongji University
2021-2023
Shanghai Skin Disease Hospital
2023
Central South University
2006-2022
Xiangya Hospital Central South University
2012-2022
Tongji Hospital
2021
Abstract Background The long non-coding RNA PVT1 (lncRNA PVT1) has been reported to act as an oncogenic regulator of several cancers. However, its expression and function in gallbladder cancer (GBC) remain largely unknown. Methods In situ hybridization (ISH) quantitative real-time PCR (qPCR) were performed detect the miR-143 GBC tissues cell lines. Immunohistochemistry (IHC) assays assess hexokinase 2 (HK2) protein. relationships among PVT1, HK2 evaluated using dual-luciferase reporter,...
Osteosarcoma is the most commonly occurring bone cancer in children and adolescents. Unfortunately, treatment failures are common due to development of chemoresistance, for which underlying molecular mechanisms remain unclear. In this study, we implicate DNA-binding protein HMGB1, also exerts immunoregulatory effects its secreted form, drug resistance osteosarcoma. Anticancer agents including doxorubicin, cisplatin, methotrexate each induced HMGB1 upregulation human osteosarcoma cells, RNA...
The survival of pancreatic cancer patients remains poor. However, the underlying molecular mechanism and new therapeutic target are still needed to be found. Many studies have shown that IGF2 mRNA-binding protein 2 (IGF2BP2) plays oncogenic roles in cancers. clinical significance, role mechanisms IGF2BP2 remain unclear.The expression miR-141 was detected cancer, significances were analyzed by statistical analysis. function determined vitro vivo, investigated. gene copy number variation (CNV)...
Background: Ethanol abuse, especially binge drinking, can be toxic to human organs. However, there have been few studies on the genotoxicity induced by ethanol in peripheral lymphocytes under drinking conditions. The purpose of this study was investigate oxidative DNA damage vitro and possible mechanism associated with metabolism. concentrations investigated were 50 100 mM, which are equal blood after drinking. maximum concentration we used 150 mM although it is not typical seen during most...
MIR34A (microRNA 34a) is a tumor suppressor gene, but how it regulates chemotherapy response and resistance not completely understood. Here, we show that the microRNA MIR34A-dependent high mobility group box 1 (HMGB1) downregulation inhibits autophagy enhances chemotherapy-induced apoptosis in retinoblastoma cell. HMGB1 multifaceted protein with key role autophagy, self-degradative, homeostatic process context-specific cancer. expression through direct MIR34A-binding site within 3′...
Purpose: The ectopic expression of N6-methyladenosine (m6A) associated genes is a common feature multiple tumors. However, little known about the status and prognostic value these in human breast cancer (BRC). Herein, we conducted comprehensive analysis to identify profiling clinical significance m6A-related genomic targets BRC. Materials Methods: data including 1109 BRC tissues 113 normal were obtained from Cancer Genome Atlas (TCGA) database evaluate mRNA levels targets. In addition, 6...
Abstract Introduction To investigate the significance of changes in regulatory T cells (Tregs) activity and its relationship with sepsis, as well outcome patients major burns. Methods The periphery blood samples 106 were collected on post-burn days 1, 3, 7, 14, 21. Tregs isolated their phenotypes (cytotoxic T-lymphocyte-associated antigen 4 forkhead/winged helix transcription factor p3) analyzed by flow cytometry, contents cytokines (interleukin-10 transforming growth factor-β1) released...
Emerging evidence has shown that microRNA-126 (miR-126) is aberrantly downregulated and plays a vital role in carcinogenesis various cancers, including HCC. However, the underlying biological mechanisms of miR-126 HCC are still largely unknown. In present study, we found was both tissues cell lines. Low expression level associated with poor overall survival (OS), late TNM stage presence recurrence. Overexpression significantly decreased proliferation, metastasis promoted apoptosis vitro....
Gallbladder cancer (GBC) is the most general biliary tract malignancy, with poor prognosis due to rapid tumor progression and lack of specific symptoms. Lactate dehydrogenase‐A (LDHA) can promote Warburg effect produce lactate Adenosine Triphosphate (ATP) in aerobic condition, which contributes oncogenesis metastasis drug resistance various cancers. However, expression functional role LDHA GBC are largely unknown. We determined that was over‐expressed tissues compared normal tissues, also an...
Gallbladder carcinoma (GBC) is the most highly aggressive cancer of biliary tract, but effective therapeutics are lacking. Emerging evidence has unveiled that miR-139-5p aberrantly downregulated in cancers, including GBC. However, functions and mechanisms GBC remain unclear.MiR-139-5p-overexpression was established cell lines, after which proliferation, migration, invasion, colony formation, glucose metabolism were assayed vitro. Subsequently, bioinformatics prediction dual-luciferase...
Abstract The DEAD/DEAH box helicase 11 (DDX11) plays vital roles in regulating the initiation of DNA replication. However, its precise function and regulation hepatocellular carcinoma (HCC) have never been reported yet. In current study, we found that DDX11 was overexpressed HCC tissues. High expression positively correlated with large tumor size, multiplicity, late tumor-node-metastasis (TNM) stage poor prognosis. Additional, gain-of-function loss-of-function experimental results revealed...
We performed DNA analysis using cord blood samples on 86 male Malay neonates diagnosed as G6PD deficiency in the National University of Malaysia Hospital by a combination rapid PCR-based techniques, single-stranded conformation polymorphism (SSCP) and sequencing. found 37.2% were 871G>A (G6PD Viangchan), 26.7% nt 563 C>T Mediterranean) 15.1% 487G>A Mahidol) followed 4.7% 1376G>T Canton), 3.5% 383T>C Vanua Lava), 592C>T Coimbra), 2.3% 1388G>A Kaiping), 1360C>T Union), 1003G>A Chatham), 1.2%...
Astragalus polysaccharides (APS) isolated from one of the Chinese herbs, mongholicus, are known to have a variety immunomodulatory activities. However, it is not yet clear whether APS can exert an effect on immune functions regulatory T cells (Tregs). This study was carried out investigate function peripheral blood Tregs in postburn sepsis.BALB/C mice were randomly divided into six groups as follows: sham burn group, control (burn without infection animals) plus P. aeruginosa with (50 mg/kg)...
Both apoptosis ("self-killing") and autophagy ("self-eating") are evolutionarily conserved processes, their crosstalk influences anticancer drug sensitivity cell death. However, the underlying mechanism remains unclear. Here, we demonstrated that HMGB1 (high mobility group box 1), normally a nuclear protein, is crucial regulator of TNFSF10/TRAIL (tumor necrosis factor [ligand] superfamily, member 10)-induced cancer Activation PARP1 (poly [ADP-ribose] polymerase 1) was required for...
Gallbladder cancer (GBC) is a highly lethal disease and the most common biliary tract malignant tumor with poor prognosis. Accumulating evidence indicates that cluster of differentiation 44 (CD44) overexpressed in several malignancies has crucial role development cancer. However, its expression function GBC are unclear. The aim this study was to explore CD44 GBC.The measured by immunohistochemistry. Tissue microarray analysis used confirm relationship between clinical outcomes patients. EDU...
Abstract Breast cancer (BRCA) is the second leading cause of cancer‐related death among female worldwide. Recent studies have revealed that LACTB was frequently repressed and functioned as a bona fide new tumor suppressor in series cancers, including BRCA. However, molecular mechanisms underlying dysregulation BRCA not been reported. In present study, we find associated with poor prognosis by tissue microarray (TMA) analysis. Moreover, confirm direct target miR‐374a, which significantly...
Most cancers rely disproportionately on glycolysis for energy even in the presence of an adequate oxygen supply, a condition known as “aerobic glycolysis,” or “Warburg effect.” Pyruvate dehydrogenase E1α subunit (PDHA1) is one main factors metabolic switch from oxidative phosphorylation (OXPHOS) to aerobic and has been suggested be closely associated with tumorigenesis. Here we observed that PDHA1 protein was reduced hepatocellular carcinoma (HCC) specimens by immunohistochemistry Western...