A5101722683- Immune Response and Inflammation
- Natural Language Processing Techniques
- Topic Modeling
- Burn Injury Management and Outcomes
- Speech Recognition and Synthesis
- Immune Cell Function and Interaction
- Immune cells in cancer
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Speech and dialogue systems
- Adipokines, Inflammation, and Metabolic Diseases
- T-cell and B-cell Immunology
- Pharmacological Effects of Natural Compounds
- Heme Oxygenase-1 and Carbon Monoxide
- Bone and Joint Diseases
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Wound Healing and Treatments
- Vitamin C and Antioxidants Research
- Orthopaedic implants and arthroplasty
- Inflammation biomarkers and pathways
- Traditional Chinese Medicine Analysis
First Hospital of Jilin University
2012-2025
Hebei University of Chinese Medicine
2021-2025
Chinese PLA General Hospital
2010-2024
Xi'an Jiaotong University
2024
Jilin University
2012-2023
Nanjing Medical University
2023
Henan University of Traditional Chinese Medicine
2023
Carnegie Mellon University
2023
GTx (United States)
2019
First Affiliated Hospital of Chinese PLA General Hospital
2008-2018
Creating the Babel Fish, a tool that helps individuals translate speech between any two languages, requires advanced technological innovation and linguistic expertise. Although conventional speech-to-speech translation systems composed of multiple subsystems performing in cascaded fashion exist1–3, scalable high-performing unified systems4,5 remain underexplored. To address this gap, here we introduce SEAMLESSM4T–Massively Multilingual Multimodal Machine Translation–a single model supports...
Yun Tang, Hongyu Gong, Ning Dong, Changhan Wang, Wei-Ning Hsu, Jiatao Gu, Alexei Baevski, Xian Li, Abdelrahman Mohamed, Michael Auli, Juan Pino. Proceedings of the 60th Annual Meeting Association for Computational Linguistics (Volume 1: Long Papers). 2022.
Abstract Background Sustained yet intractable immunosuppression is commonly observed in septic patients, resulting aggravated clinical outcomes. However, due to the substantial heterogeneity within precise indicators deciphering trajectories and immunological alterations for patients remain largely lacking. Methods We adopted cross-species, single-cell RNA sequencing (scRNA-seq) analysis based on two published datasets containing circulating immune cell profile of as well atlas murine model...
Abstract Introduction To investigate the significance of changes in regulatory T cells (Tregs) activity and its relationship with sepsis, as well outcome patients major burns. Methods The periphery blood samples 106 were collected on post-burn days 1, 3, 7, 14, 21. Tregs isolated their phenotypes (cytotoxic T-lymphocyte-associated antigen 4 forkhead/winged helix transcription factor p3) analyzed by flow cytometry, contents cytokines (interleukin-10 transforming growth factor-β1) released...
Rationale: Evident immunosuppression has been commonly seen among septic patients, and it is demonstrated to be a major driver of morbidity.Nevertheless, comprehensive view the host immune response sepsis lacking as majority studies on have focused specific type cells.Methods: We applied multi-compartment, single-cell RNA sequencing (scRNA-seq) dissect heterogeneity within cell subsets during progression cecal ligation puncture (CLP) mouse model.Flow cytometry multiplex immunofluorescence...
Astragalus polysaccharides (APS) isolated from one of the Chinese herbs, mongholicus, are known to have a variety immunomodulatory activities. However, it is not yet clear whether APS can exert an effect on immune functions regulatory T cells (Tregs). This study was carried out investigate function peripheral blood Tregs in postburn sepsis.BALB/C mice were randomly divided into six groups as follows: sham burn group, control (burn without infection animals) plus P. aeruginosa with (50 mg/kg)...
Dendritic cell (DC) can be stimulated by both exogenous pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharide (LPS) and endogenous damage-associated (DAMPs) high mobility group box-1 protein (HMGB1). MicroRNAs (miRNAs) act post-transcriptional fine tuners of mRNA. Studies have focused mostly on the potential role miRNAs in DCs maturation triggered PAMPs, especially LPS, however, little is known about regulatory mechanism underlying effects DC mediated DAMPs, including...
With both in vivo and vitro experiments, the present study was conducted to investigate effect of regulatory T cell (Treg) on promoting T-lymphocyte apoptosis its mechanism through transforming growth factor-beta (TGF-β1) signaling mice. A murine model polymicrobial sepsis reproduced by cecal ligation puncture (CLP); PC61 anti-TGF-β antibodies were used decrease counts CD4+CD25+ Tregs inhibit TGF-β activity, respectively. Splenic CD4+CD25− cells isolated. Phenotypes, including cytotoxic...
Paul-Ambroise Duquenne, Hongyu Gong, Ning Dong, Jingfei Du, Ann Lee, Vedanuj Goswami, Changhan Wang, Juan Pino, Benoît Sagot, Holger Schwenk. Proceedings of the 61st Annual Meeting Association for Computational Linguistics (Volume 1: Long Papers). 2023.
Large-scale automatic speech translation systems today lack key features that help machine-mediated communication feel seamless when compared to human-to-human dialogue. In this work, we introduce a family of models enable end-to-end expressive and multilingual translations in streaming fashion. First, contribute an improved version the massively multimodal SeamlessM4T model-SeamlessM4T v2. This newer model, incorporating updated UnitY2 framework, was trained on more low-resource language...
In the context of accelerated globalization, prominence spoken English for cross-cultural communication has been underscored. A growing demand exists objective, large-scale, and efficient evaluations English. Artificial intelligence (AI) consequently rigorously investigated incorporated in evaluation. Nonetheless, much existing research tends to focus on singular evaluation dimensions, leading performance limitations when confronted with diverse, stylistically varied, or samples. this study,...
Abstract Interleukin-37 (IL-37) possesses the function of down-regulate systemic and local inflammation. It is unknown whether IL-37 expressed in human regulatory T cells (Tregs) its role modulating immune response Tregs. In present study, cell surface molecules secretory cytokines were analyzed order to determine regulating inhibitory effect CD4 + CD25 Meanwhile, effects on differentiation proliferation as co-culture Treg/CD4 − also investigated. was showed that cytoplasm Tregs levels...
Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands TAM receptors (Tyro3, Axl, and Mertk), its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for active suppression autoimmunity. The present study was designed to investigate whether Tregs express potential Gas6-TAM signal in regulating suppressive function Tregs. Methods. protein mRNA levels were determined by using Western blot,...
Abstract Background Burn survivors develop long-term cognitive impairment with increased inflammation and apoptosis in the brain. Gelsolin, an actin-binding protein capping severing activities, plays a crucial role septic response. We investigated if gelsolin infusion could attenuate neural damage burned mice. Methods Mice 15% total body surface area burns were injected intravenously bovine serum albumin as placebo (2 mg/kg), or low mg/kg) high doses (20 of gelsolin. Samples harvested at 8,...
Fluoride is a double-edged sword. It was widely used for early caries prevention while excessive intake caused toxicology effect, affected enamel development, and resulted in dental fluorosis. The study aimed to evaluate the protective effect mechanism of Epigallocatechin-3-gallate (EGCG) on apoptosis induced by fluoride ameloblast-like cells. We observed that NaF triggered apoptotic alterations cell morphology, arrested cycle at G1, up-regulating Bax down-regulating Bcl-2. activated...
Background: Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway plays an important role in sepsis, transducing a multitude inflammatory signals. To date, knowledge JAK/STAT sepsis is limited. This study was to investigate the potential mediating multiple organ damage mortality septic rats. Our data showed that inhibition JAK2/STAT3 attenuated cecal ligation puncture-induced 48 hours Methods: A total 98 male Wistar rats were randomly divided into 4 groups as...