A5051535160- Sepsis Diagnosis and Treatment
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phagocytosis and Immune Regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Immune cells in cancer
- Curcumin's Biomedical Applications
- Autophagy in Disease and Therapy
- Erythrocyte Function and Pathophysiology
- Pharmacological Effects of Natural Compounds
- Heme Oxygenase-1 and Carbon Monoxide
- Paraquat toxicity studies and treatments
- Berberine and alkaloids research
- Blood properties and coagulation
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Inflammation biomarkers and pathways
- Antimicrobial Resistance in Staphylococcus
- Ion Channels and Receptors
- Crystallography and molecular interactions
- Bioactive natural compounds
- Inflammasome and immune disorders
- Synthesis and biological activity
- Plant-based Medicinal Research
Wenzhou Medical University
2015-2024
First Affiliated Hospital of Wenzhou Medical University
2015-2024
Wenzhou Hospital of Traditional Chinese Medicine
2023
Nanjing University
2015-2016
China Pharmaceutical University
2016
Capital Normal University
2009
Myocardial injury and cardiovascular dysfunction are serious consequences of sepsis contribute to high mortality. Currently, the pathogenesis myocardial in is still unclear, therapeutic approaches limited. In this study, we investigated protective effect emodin on septic underlying mechanism. Lipopolysaccharide (LPS)‐induced C57BL/6 mice cardiomyocytes were used as models vivo vitro, respectively. The results showed that alleviated cardiac dysfunction, improved survival rate LPS‐induced...
Sirtuin 1 (SIRT1) acts via the deacetylation of a number crucial transcription factors and has been implicated in various biological processes, including oxidative stress. Previous studies have indicated that nuclear factor, erythroid 2‑like 2 (NRF2) is an effective target antioxidant therapy for paraquat (PQ) poisoning. However, association between SIRT1 NRF2 their effects PQ‑induced stress remains to be elucidated. The current study demonstrated PQ exposure upregulated expression following...
Sepsis is a multi-organ dysfunction characterized by an unregulated host response to infection. It associated with high morbidity, rapid disease progression, and mortality. Current therapies mainly focus on symptomatic treatment, such as blood volume supplementation antibiotic use, but their effectiveness limited. Th17/Treg balance, based its inflammatory property, plays crucial role in determining the direction of regression organ damage sepsis patients. This review provides summary changes...
Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands TAM receptors (Tyro3, Axl, and Mertk), its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for active suppression autoimmunity. The present study was designed to investigate whether Tregs express potential Gas6-TAM signal in regulating suppressive function Tregs. Methods. protein mRNA levels were determined by using Western blot,...
Gastric ulcers (GU) are a disease of the gastrointestinal tract that can be caused by excessive alcohol consumption and heavy use nonsteroidal anti-inflammatory drugs. GU manifests predominantly as pathological damage, such extensive inflammatory erosion superficial bleeding gastric mucosa. Oxidative stress damage response now considered important predisposing factors for GU, suggesting antioxidant drugs could treatments GU. Nanoparticle drug carriers offer many advantages over conventional...
A common complication of sepsis is acute lung injury (ALI), which associated with an onset, rapid disease changes, and high mortality. Regulatory T (Treg) helper 17 (Th17) cells comprise CD4+ cell subsets, strongly influence inflammation during ALI. In this study, we investigated the effect berberine (BBR), antioxidant, anti-inflammatory, immunomodulatory drug, on inflammatory response immune state in mice sepsis.A mouse model cecal ligation puncture (CLP) was established. The were...
Introduction: Sepsis is a severe life-threatening infection that induces series of dysregulated physiologic responses and results in organ dysfunction. Acute lung injury (ALI), the primary cause respiratory failure brought on by sepsis, does not have specific therapy. Protopine (PTP) an alkaloid with antiinflammatory antioxidant properties. However, function PTP septic ALI has yet been documented. This work sought to investigate how affected mechanisms involved damage, including...
Dendritic cell (DC) dysfunction plays a central role in sepsis-induced immunosuppression. Recent research has indicated that collective mitochondrial fragmentation contributes to the of immune cells observed during sepsis. PTEN-induced putative kinase 1 (PINK1) been characterized as guide for impaired mitochondria can keep homeostasis. However, its function DCs sepsis and related mechanisms remain obscure. In our study, we elucidated effect PINK1 on DC underlying mechanism action.Cecal...
ABSTRACT T cell exhaustion is the main cause of sepsis-induced immunosuppression and associated with poor prognosis. Nicotinamide adenine dinucleotide (NAD + ) well known for its anti-aging effect, but role in remains to be elucidated. In present study, using a classic septic animal model, we found that levels NAD downstream molecule, which sirtuins 1 (SIRT1), cells sepsis were decreased. Supplementation nicotinamide ribose (NR), precursor , right after cecal ligation puncture significantly...
Tolerogenic dendritic cells (DCs) are associated with poor prognosis of sepsis. Matrix metalloproteinases (MMPs) have been shown to immunomodulatory effects. However, whether MMPs involved in the functional reprogramming DCs is unknown. The study aims investigate role sepsis-induced tolerance and potential mechanisms. A murine model late sepsis was induced by cecal ligation puncture (CLP). expression levels members MMP family were detected tolerogenic using microarray assessment. roles...
Excessive inflammation and increased apoptosis of macrophages contribute to organ damage poor prognosis sepsis. Ginkgolic acid (GA) is a natural constituent extracted from the leaves Ginkgo biloba, that can regulate apoptosis. The present study aims investigate potential effect GA in treating sepsis its possible mechanisms.Here, classic septic mice model lipopolysaccharide (LPS)-induced RAW 264.7 were established. Cytokines serum culture supernatant detected by ELISA, mRNA levels them...
As an important enzyme in bacterial protein biosynthesis, tyrosyl-tRNA synthetase (TyrRS) has been absorbing therapeutic target for exploring novel antibacterial agents. A series of metronidazole-based agents synthesized and identified as TyrRS inhibitors with low cytotoxicity significant activity, especially against Gram-negative organisms. Of the compounds obtained, 4f is most potent agent which inhibited growth Pseudomonas aeruginosa ATCC 13525 (MIC = 0.98 μg/mL) exhibited TryRS...
Background Immune suppression contributes to nosocomial infections (NIs) and poor prognosis in sepsis. Recent studies revealed that CD71 + erythroid cells had unappreciated immunosuppressive functions. This study aimed investigate the values of (CECs) predicting NIs among adult septic patients. The potential factors associated with expansion CECs were also explored. Methods In total, 112 patients 32 critically ill controls enrolled. frequencies cells, CD235a CD45 measured by flow cytometry....
Critically ill patients with preexisting kidney dysfunction (PKD) are at high risk for acute injury (AKI). Nevertheless, there is no criteria screening and classifying AKI in PKD. In this study, after assessing relationship between the change SCr from baseline in-hospital mortality, a new criteria, named APKD, identifying PKD was proposed. APKD defined critically as an absolute increase of ≥ 0.2 mg/dL within 48 h or 1.1 times over 7 d. detected more among compared other criteria....