A5024833445- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Analytical Chemistry and Chromatography
- Plant Disease Resistance and Genetics
- Plant-Microbe Interactions and Immunity
- Traditional Chinese Medicine Analysis
- Immune Response and Inflammation
- HER2/EGFR in Cancer Research
- Plant Pathogens and Resistance
- Redox biology and oxidative stress
- Traditional Chinese Medicine Studies
- Phagocytosis and Immune Regulation
- Mass Spectrometry Techniques and Applications
- Immune Cell Function and Interaction
- Metabolism and Genetic Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Reproductive System and Pregnancy
- Zebrafish Biomedical Research Applications
- Enzyme Production and Characterization
- Tea Polyphenols and Effects
- Natural product bioactivities and synthesis
- Cytokine Signaling Pathways and Interactions
- Quantum-Dot Cellular Automata
- Ginseng Biological Effects and Applications
Guangzhou University of Chinese Medicine
2024-2025
China Pharmaceutical University
2016-2025
Shanghai Jiao Tong University
2015-2025
Yancheng First People's Hospital
2025
Xuzhou Medical College
2025
Nantong University
2025
Minhang District Central Hospital
2024
Fudan University
2024
Key Laboratory of Guangdong Province
2024
Zhangzhou Normal University
2023
Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis manshurica Rupr., which herbal medicine used in traditional Chinese for treatment arthritis. C-AR exerts anti-inflammatory and immunosuppressive properties, but little known about its action suppression fibroblast activation. Low oxygen tension TGF-β1 induction synovium contribute to fibrosis arthrits. This study was designed investigate effect clematichinenoside on synovial aspects hypoxic HIF-1α...
This work developed DNA amplifier logic gates (AND-OR, OR-AND, FAN-IN, FAN-OUT, and 4-bit square-root circuits) using a flap endonuclease 1 (FEN1)-catalyzed signal amplification reaction, for the fastest compact computing.
\textsf{Holant} is an essential framework in the field of counting complexity. For over fifteen years, researchers have been clarifying complexity classification for complex-valued on Boolean domain, a challenge that remains unresolved. In this article, we prove dichotomy domain when non-trivial signature odd arity exists. This based \textsf{\#EO}, and consequently $\text{FP}^\text{NP}$ vs. \#P as well, stating each problem either or \#P-hard. Furthermore, establish generalized version...
Abstract The limited replicability of retention data hinders its application in untargeted metabolomics for small molecule identification. While order models hold promise addressing this issue, their predictive reliability is by uncertain generalizability. Here, we present the ROASMI model, which enables reliable prediction within a well-defined domain coupling data-driven molecular representation and mechanistic insights. generalizability proven 71 independent reversed-phase liquid...
ABSTRACT Aims This study aimed to test the hypothesis that nuclear factor of activated T cells 1 (NFAT1) signaling contributes bone cancer pain by regulating interleukin (IL)‐18 expression in spinal microglia. Methods was performed on male mice using a Lewis lung carcinoma‐induced model. Nociceptive behaviors were evaluated measuring mechanical allodynia, thermal hyperalgesia, and spontaneous pain. Expression levels measured via real‐time quantitative polymerase chain reaction, western...
Social isolation (SI) is a prevalent issue in modern society, particularly exacerbated during the COVID-19 pandemic, and it significant contributor to depressive disorders. Inflammation-related markers are upregulated patients with major disorder (MDD) unresponsive first-line selective serotonin reuptake inhibitor (SSRI) antidepressants. This study investigates role of formyl peptide receptor 2 (FPR2), G-protein coupled expressed central peripheral immune cells, SI-induced depression. We...
Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands TAM receptors (Tyro3, Axl, and Mertk), its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for active suppression autoimmunity. The present study was designed to investigate whether Tregs express potential Gas6-TAM signal in regulating suppressive function Tregs. Methods. protein mRNA levels were determined by using Western blot,...
Late blight, caused by Phytophthora infestans (P. infestans), is a devastating disease in potato worldwide. Our previous study revealed that the Solanum andigena genotype 03112-233 resistant to P. isolate 90128, but susceptible super race isolate, CN152. In this study, we confirmed diagnostic resistance gene enrichment sequencing (dRenSeq) of toward 90128 most likely based on distinct new R gene(s). To gain an insight into mechanism governs or susceptibility 03112-223, comparative...
Maternal-fetal crosstalk during embryo implantation is complex and regulated by local signaling molecules. Chemokines their receptors are critical components required for the process of pregnancy. This study aimed to explore whether human first-trimester trophoblast cells (TCs) were capable modulating migration invasion decidual epithelial (DECs) via CXCL12/CXCR4/CXCR7 signaling.The expression CXCR4 CXCR7 in DECs was examined immunohistochemistry, immunocytochemistry, immunofluorescence,...
Liquid-liquid phase separation (LLPS) partitions cellular contents, underlies the formation of membraneless organelles and plays essential biological roles. To date, most research on LLPS has focused proteins, especially RNA-binding proteins. However, accumulating evidence demonstrated that RNAs can also function as 'scaffolds' play roles in seeding or nucleating granules. better utilize knowledge dispersed published literature, we here introduce RNAPhaSep (http://www.rnaphasep.cn), a...
Abstract Background The accurate evaluation of BRAF V600E mutation in preoperative fine‐needle aspiration cytology (FNAC) specimens is important for making management decisions thyroid nodules (TNs). aim this study was to assess the false‐positive and false‐negative mutations FNAC their influence on diagnosis TN. Methods This prospective enrolled 292 269 patients who underwent analysis using amplification refractory system‐quantitative real‐time polymerase chain reaction (ARMS‐qPCR) both...
Glutathione (GSH) redox control and arginine metabolism are critical in regulating the physiological response to injury oxidative stress. Quantification assessment of GSH/arginine supports monitoring metabolic pathway shifts during pathological processes their linkages regulation. However, assessing status organisms with complex matrices is challenging, single molecule analysis may not be accurate for interrogating cells vivo. Herein, guided by a paired derivatization strategy, we present...
Lipopolysaccharide (LPS)-activated pro-inflammatory responses play a critical role in sepsis, life-threatening condition. This study investigates the of origin recognition complex subunit 6 (ORC6) LPS macrophages and monocytes. Silencing ORC6 using targeted shRNA significantly reduced LPS-induced expression production IL-1β (interleukin-1 beta), TNF-α (tumor necrosis factor alpha), IL-6 (interleukin-6) THP-1 human macrophages, peripheral blood mononuclear cells (PBMCs), bone marrow-derived...
Background: High mobility group box-1 protein (HMGB1), a ubiquitous nuclear protein, which is recognized as danger-associated molecular pattern (DAMP) triggering activation of the innate immune system. Previous studies have shown that HMGB1 also plays role in T cell-mediated immunity, but effect on apoptosis cells and its precise mechanism remain to be determined. Methods: Two kinds assay techniques were used, i.e., Annexin V-FITC conjunction with PI identify early apoptotic cells, Hoechst...