Chong‐Ke Zhao

ORCID: 0000-0003-0968-4464
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About
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Research Areas
  • Thyroid Cancer Diagnosis and Treatment
  • Radiomics and Machine Learning in Medical Imaging
  • Ultrasound and Hyperthermia Applications
  • Head and Neck Anomalies
  • Ultrasound Imaging and Elastography
  • BRCA gene mutations in cancer
  • Cervical Cancer and HPV Research
  • Thyroid and Parathyroid Surgery
  • AI in cancer detection
  • Ovarian cancer diagnosis and treatment
  • MRI in cancer diagnosis
  • Photoacoustic and Ultrasonic Imaging
  • Neuroendocrine Tumor Research Advances
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Veterinary medicine and infectious diseases
  • Artificial Intelligence in Healthcare and Education
  • Musculoskeletal synovial abnormalities and treatments
  • Oral Health Pathology and Treatment
  • Mathematical Biology Tumor Growth
  • Ultrasound in Clinical Applications
  • PI3K/AKT/mTOR signaling in cancer
  • Lung Cancer Diagnosis and Treatment
  • Tea Polyphenols and Effects
  • TGF-β signaling in diseases
  • Telemedicine and Telehealth Implementation

Zhongshan Hospital
2024-2025

Fudan University
2004-2025

Ningxia Medical University
2025

Shanxi Normal University
2025

Sun Yat-sen University
2024

Ping An (China)
2024

Shanghai Institute of Hematology
2024

The First Affiliated Hospital, Sun Yat-sen University
2024

Shanghai Tenth People's Hospital
2016-2020

Tongji University
2016-2020

Ultrasonography (renamed from the Journal of Korean Society Ultrasound in Medicine January 2014), official English-language journal (KSUM), is an international peer-reviewed academic dedicated to practice, research, technology, and education dealing with medical ultrasound, Aims Scope:Ultrasonography ultrasound.It published four times per year: 1, April July October 1. Original articles, topical reviews, pictorial essays, notable case reports are covering state-of-the-art content. also...

10.14366/usg.18037 article EN cc-by-nc ULTRASONOGRAPHY 2018-10-01

Background: The risk stratification system of the American College Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) for thyroid nodules is affected by low diagnostic specificity. Machine learning (ML) methods can optimize performance in medical image analysis. However, it unknown which ML-based pattern more effective improving reducing nodule biopsies. Therefore, we compared ML-assisted visual approaches radiomics with ACR TI-RADS unnecessary fine-needle aspiration biopsy...

10.1089/thy.2020.0305 article EN Thyroid 2020-08-12

To assess the factors associated with initial incomplete ablation (ICA) after radiofrequency for benign thyroid nodules (BTNs).69 BTNs (mean volume 6.35±5.66 ml, range 1.00-25.04 ml) confirmed by fine-needle aspiration cytology (FNAC) in fifty-four patients were treated ultrasound-guided percutaneous (RFA) and local treatment efficacy was immediately assessed intra-procedural contrast-enhanced ultrasound (CEUS). The RFA performed a bipolar electrode (CelonProSurge 150-T20, output power: 20...

10.3233/ch-16208 article EN Clinical Hemorheology and Microcirculation 2016-12-17

The role of mechanical stress and transforming growth factor beta 1 (TGF-β1) is important in the initiation progression osteoarthritis (OA). However, underlying molecular mechanisms are not clearly known.In this study, TGF-β1 from osteoclasts knee joints were analyzed using a co-cultured cell model an OA rat model, respectively. Five patients with femoral neck fracture (four female one male, mean 73.4 years (68 to 79)) recruited between January 2015 December 2015. Results showed that was...

10.1302/2046-3758.711.bjr-2018-0057.r1 article EN cc-by-nc-nd Bone and Joint Research 2018-11-01

To evaluate the diagnostic performance of parametric imaging with contrast-enhanced ultrasound(CEUS) for differentiating hepatocellular carcinoma(HCC) from metastatic liver cancer(MLC).30 HCCs (mean diameter, 3.6±1.3 cm; range, 2.1-5.0 cm) and 30 MLCs 2.8±1.5 1.2-5.0 pathologically diagnosed or confirmed by clinical criteria that underwent CEUS were randomly included. was carried out using a multifrequency transducer (2-4 MHz) bolus injection 2.4 mL SonoVue. The clips targeted lesion...

10.3233/ch-162060 article EN Clinical Hemorheology and Microcirculation 2016-11-25

To prospectively evaluate the diagnostic performance of 3-dimensional (3D) shear wave elastography (SWE) for assessing thyroid nodules.A total 176 surgically or cytologically confirmed nodules (63 malignant and 113 benign) in patients who had undergone conventional ultrasound (US), 2-dimensional (2D) SWE, 3D SWE examinations were included this study. Quantitative elasticity values (mean elasticity, maximum standard deviation a large region interest mean 2-mm interest) measured on 2D SWE....

10.1002/jum.14531 article EN Journal of Ultrasound in Medicine 2018-01-09

The aim of this study was to evaluate the diagnostic performance strain elastography, acoustic radiation force impulse (ARFI) imaging and point shear wave elastography (p-SWE) for assessment predominant types intestinal stenosis in Crohn disease.Twenty-five patients were enrolled study, among whom 25 suspicious stenoses segments studied using gray scale ultrasonography. All 3 methods performed, all underwent endoscopy within 24 hours with pathologic biopsy. sensitivity, specificity,...

10.1002/jum.14989 article EN Journal of Ultrasound in Medicine 2019-03-28

To compare the diagnostic performance and unnecessary biopsy rates for recommending fine needle aspiration (FNA) of Thyroid Imaging Reporting Data Systems proposed by American College Radiology (ACR TI-RADS), Association (ATA) guidelines, TI-RADS Kwak (Kwak Korean Association/Korean Society (KTA/KSThR) guidelines malignancy risk stratification thyroid nodules (TNs).The study included 1271 TNs whose cytologic results or surgical pathologic findings were available. Ultrasound images these...

10.3233/ch-190778 article EN Clinical Hemorheology and Microcirculation 2020-01-17

Abstract Background The accurate evaluation of BRAF V600E mutation in preoperative fine‐needle aspiration cytology (FNAC) specimens is important for making management decisions thyroid nodules (TNs). aim this study was to assess the false‐positive and false‐negative mutations FNAC their influence on diagnosis TN. Methods This prospective enrolled 292 269 patients who underwent analysis using amplification refractory system‐quantitative real‐time polymerase chain reaction (ARMS‐qPCR) both...

10.1002/cam4.2478 article EN cc-by Cancer Medicine 2019-08-08

Objective To investigate the feasibility of remotely providing routine ultrasound (US) examinations to patients using a fifth‐generation‐based robot‐assisted tele‐ultrasonography (RATU) system in real‐world setting. Methods Between September 2020 and May 2021, we conducted prospective large‐scale study RATU provide US for on limited‐source island locate. An on‐site radiologist performed examinations, which served as reference diagnosis. Five tele‐radiologists then from Central Shanghai. We...

10.1002/jum.16638 article EN Journal of Ultrasound in Medicine 2025-01-22

This paper presents a basic model for the therapeutic effect of two drugs on patients with early cervical cancer. Two cases are considered: constant control and optimal control. For case one, system is proved to have unique non-negativity solution if initial values positive; then sufficient conditions existence stability equilibriums derived; Hopf bifurcation also considered. two, by using Pontryagin's Maximum Principle, we get solution. Some examples numerical simulations presented....

10.1080/10255842.2025.2457601 article EN Computer Methods in Biomechanics & Biomedical Engineering 2025-02-08

Ferroptosis is a novel form of regulated cell death characterized by the iron-dependent accumulation lipid peroxides. Recent research has suggested that ferroptosis in osteoblasts contributes to steroid-induced osteonecrosis femoral head (SONFH). However, relationship between and SONFH remains unclear. In this study, vitro experiments show dexamethasone (Dex) treatment reduces expressions key regulators, SLC7A11 GPX4, MC3T3-E1 cells. This reduction leads decrease intracellular glutathione...

10.3724/abbs.2025014 article EN cc-by-nc-nd Acta Biochimica et Biophysica Sinica 2025-03-01

To compare the efficiency of four different ultrasound (US) Thyroid Imaging Reporting and Data Systems (TI-RADS) in malignancy risk stratification surgically resected thyroid nodules (TNs). The study included 547 benign TNs 464 malignant TNs. US images were retrospectively reviewed categorized according to TI-RADSs published by Horvath E et al. (TI-RADS H), Park P), Kwak K) Russ R). diagnostic performances for then compared. At multivariate analysis, among suspicious features, marked...

10.1038/s41598-017-11863-0 article EN cc-by Scientific Reports 2017-09-11

The purpose of the study was to explore differences conventional ultrasound characteristics, thyroid imaging reporting and data system (TI-RADS) category shear wave speed (SWS) measurement between follicular adenoma (FA) carcinoma (FTC). Twenty-eight FTCs 67 FAs proven by surgery were retrospectively included for analysis. Conventional point-shear elastography (p-SWE) performed in all patients. features, American Thyroid Association (ATA) TI-RADS College Radiology (ACR) category, SWS...

10.3233/ch-190750 article EN Clinical Hemorheology and Microcirculation 2020-04-07

Abstract To evaluate the associated factors leading to misdiagnosis with VTIQ for differentiation between benign from malignant thyroid nodules (TNs). The study included 238 TNs and 150 TNs. Conventional ultrasound (US) features parameters were obtained compared reference standard of histopathological and/or cytological results. Binary logistic regression analysis was performed select independent variables misdiagnosis. maximum shear wave speed (SWS) (SWS-max), mean SWS (SWS-mean), SWS-ratio...

10.1038/srep41958 article EN cc-by Scientific Reports 2017-02-03

To investigate the diagnostic performance of combination ultrasound (US) thyroid imaging reporting and data system (TI-RADS) a new US scoring for diagnosing nodules (TNs) with indeterminate results (Bethesda categories III, IV V) on fine-needle aspiration (FNA) cytology. 453 patients cytologically TNs were included in this study. Multivariate analyses performed to construct system. The performances TI-RADS combined method evaluated compared. revealed that marked hypoechogenicity, taller than...

10.1038/s41598-017-07353-y article EN cc-by Scientific Reports 2017-07-25

The purpose of this study was to comparatively evaluate the two different shear wave speed (SWS) imaging systems Toshiba elastography (T-SWE) and SuperSonic SWE (S-SWE) in distinguishing malignant from benign thyroid nodules (TNs).140 patients with 140 focal TNs were enrolled underwent T-SWE S-SWE before fine-needle aspiration (FNA) biopsy or surgery. indices mean, standard deviation maximum values (E-mean, E-SD E-max) elastic modulus measured on a color-coded mapping. receiver operating...

10.3233/ch-16197 article EN Clinical Hemorheology and Microcirculation 2016-12-16

Abstract To assess the association between BRAF V600E mutation and ultrasound (US) features in papillary thyroid carcinoma (PTC) patients with without Hashimoto’s thyroiditis (HT). We retrospectively reviewed US status of 438 consecutive surgically confirmed PTCs. The were analyzed. In addition, we conducted subgroup analyses terms coexistent HT. was found 86.5% (379 438). Patient age (OR: 1.028, P = 0.010), ≥ 50 y 1.904, 0.030), microcalcification 2.262, 0.015) on significantly associated...

10.1038/s41598-017-05153-y article EN cc-by Scientific Reports 2017-07-03

Non-calcified thyroid nodules are relatively difficult to diagnose only relying on features of at conventional US images.To investigate the diagnostic performances strain elastography (SE), acoustic radiation force impulse (ARFI) SE and point shear-wave speed (pSWS) measurement for non-calcified nodules.A total 201 in 195 patients were studied. They examined with ultrasound (US), SE, ARFI pSWS measurement. Their multivariable models assessed receiver operating characteristic (ROC) curve...

10.3233/ch-16178 article EN Clinical Hemorheology and Microcirculation 2016-08-16

OBJECTIVE: The aim of this study was to compare the diagnostic performance two different 2D shear wave speed imaging techniques Virtual Touch Tissue Imaging & Quantification (VTIQ) and Toshiba elastography (T-SWE) in predicting malignant thyroid nodules (TNs). MATERIALS AND METHODS : 75 TNs patients which were subject both VTIQ T-SWE examinations enrolled analyzed. Shear (SWS) values on computed (SWS_max, min, mean median). Area under receiver operating characteristic (AUROC) curve obtained...

10.3233/ch-16217 article EN Clinical Hemorheology and Microcirculation 2017-02-17

To prospectively evaluate the diagnostic performance of three-dimensional (3D) shear wave elastography (SWE) for breast lesions with quantitative stiffness information from transverse, sagittal and coronal planes.Conventional ultrasound (US), two-dimensional (2D)-SWE 3D-SWE were performed 122 consecutive patients before biopsy or surgical excision. Maximum elasticity values Young's modulus (Emax) recorded on 2D-SWE three planes 3D-SWE. Area under receiver operating characteristic curve...

10.3233/ch-180388 article EN Clinical Hemorheology and Microcirculation 2018-05-29

// Chong-Ke Zhao 1, 2, 3 , Hui-Xiong Xu Jun-Mei Cheng-Yu Sun Wei Chen Bo-Ji Liu Xiao-Wan Bo Dan Wang Shen Qu 4 1 Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School Medicine, 200072, China 2 Thyroid Center for Diseases, Endocrinology & Metabolism, Correspondence to: Xu, email: xuhuixiong@126.com Keywords: thyroid nodules, fine-needle aspiration cytology, Bethesda category III, ultrasound, acoustic...

10.18632/oncotarget.13685 article EN Oncotarget 2016-11-29
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