A5101816779- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Adipose Tissue and Metabolism
- Reconstructive Surgery and Microvascular Techniques
- Body Contouring and Surgery
- Malaria Research and Control
- Thyroid Cancer Diagnosis and Treatment
- Reconstructive Facial Surgery Techniques
- 3D Printing in Biomedical Research
- Facial Rejuvenation and Surgery Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Systemic Sclerosis and Related Diseases
- Mosquito-borne diseases and control
- Growth Hormone and Insulin-like Growth Factors
- Birth, Development, and Health
- Cellular Mechanics and Interactions
- Facial Nerve Paralysis Treatment and Research
- Head and Neck Anomalies
- Exercise and Physiological Responses
- Thyroid and Parathyroid Surgery
- Infant Nutrition and Health
- Dermatology and Skin Diseases
Southern Medical University
2016-2025
Nanfang Hospital
2016-2025
Yangzhou University
2018-2024
Shandong University of Traditional Chinese Medicine
2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
Fujian Medical University
2024
Dalian Medical University
2020-2024
Sichuan University
2024
First Affiliated Hospital of Dalian Medical University
2020-2024
Shanghai Tenth People's Hospital
2014-2023
Summary Chronic inflammation of adipose tissue is a prominent characteristic many metabolic diseases. Lipid metabolism in consistently dysregulated during inflammation, which characterized by substantial infiltration proinflammatory cells and high cytokine concentrations. Adipose caused variety endogenous factors, such as mitochondrial dysfunction, reactive oxygen species (ROS) production, endoplasmic reticulum (ER) stress, cellular senescence, ceramides biosynthesis mediators...
Background: Flap necrosis caused by inadequate blood supply is a common postoperative complication in reconstructive surgery. Because putative stem cell population within the adipose tissue has been found to possess angiogenic potential, authors sought determine whether these cells might selectively induce neovascularization and increase viability of random pattern skin flaps. Methods: Adipose-derived were isolated from inguinal fat pads ICR mice expanded ex vivo for three passages. After...
Background: The efficacy of autologous fat transplantation is reduced by absorption and fibrosis due to necrosis. Enhanced transplant neovascularization early after may reduce these outcomes. authors asked whether cell concomitant gene therapy using adipose-derived stem cells transduced with vascular endothelial growth factor (VEGF) improves survival. Methods: Human were expanded ex vivo for three passages, labeled 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine (DiI), VEGF or left...
Mesenchymal stem/progenitor cells (MSCs) are multipotent progenitors that differentiate into such lineages as bone, fat, cartilage and stromal support haemopoiesis. Bone marrow MSCs can also contribute to cardiac repair, although the mechanism for this is unclear. Here, we examine potential of from different sources generate cardiomyocytes in vitro, a means predicting their therapeutic after myocardial infarction.Mesenchymal were isolated perivascular tissue Wharton's jelly umbilical cord...
Background: Adipose-derived stem cells and other stromal vascular fraction were used more often for cell therapy, even though limitations such as poor retention rate, complicated expensive isolation processes, the use of specific laboratory equipment need to be overcome. Methods: Here, authors developed a novel but simple method generating an injectable mixture native adipose extracellular matrix. It is purely mechanical process in which lipoaspirate processed into matrix/stromal gel. The...
Introduction Glycation products accumulate during aging of slowly renewing tissue, including skin, and are suggested as an important mechanism underlying the skin process. Adipose-derived cells widely used in clinic to treat ischemic diseases enhance wound healing. Interestingly, adipose-derived stem (ASCs) also effective anti-aging therapy, although their effects remains unknown. The purpose present study was examine effect ASCs a D-galactose-induced animal model clarify mechanism....
An alkali-induced egg white hydrogel achieved ultra-stretchability, self-healing and direct 3D printability for highly sensitive electronic sensor humidity-responsive actuator fabrication.
3D bioprinting of a gradient-stiffened gelatin–alginate hydrogel accelerated wound healing by promoting the proliferation, migration, and paracrine secretion encapsulated ADSCs.
Abstract Background Adipose-derived stem cells (ASCs) represent the most advantageous choice for soft tissue regeneration. Studies proved recruitment of ASCs post injury was mediated by chemokine CXCL12, but mechanism which CXCL12 is generated after remains unclear. Migrasomes are newly discovered membrane-bound organelles that could deliver spatially and temporally in vivo. In this study, we sought to investigate whether migrasomes participate ASC-mediated Methods Discrepant asymmetrical...
Abstract This study is to compare the health-related quality of life (HRQoL) and cost-effectiveness radiofrequency ablation (RFA) open thyroidectomy (OT) for benign thyroid nodules (BTNs) treatment. HRQoL utility were assessed 404 BTN patients immediately before treatments (RFA:OT = 137:267) at 6-month visit. A analysis was performed from societal perspective in China context. Resource use (hospitalization, sick leaves) collected. We used net monetary benefit approach computed acceptability...
The major drawback of adipose grafting is its clinical unpredictability, which leads to surgeon and patient dissatisfaction. mechanisms underlying angiogenesis regeneration the graft tissue are still unclear.Mouse was processed using two different methods (fragmental integral) used identify mode graft. Cross-grafting from normal mice transgenic expressing green fluorescent protein observe origin cells during regeneration.Almost all CD31 endothelial new vessels were derived recipient. in...
Background: The apoptosis of mature adipocytes after fat grafting can result in chronic inflammation, absorption, and fibrosis, leading to unpredictable outcomes. Selective elimination may better outcomes a different underlying retention mode. authors previously developed adipocyte–free product, stromal vascular fraction gel, derived from lipoaspirate, which eliminates preserves the fraction. This study investigated regeneration mode gel grafting. Methods: Nude mice were grafted with...
Mesenchymal stem cells are an attractive cell type for cytotherapy in wound healing. The authors recently developed a novel, adipose-tissue-derived, injectable extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) therapy. This study was designed to assess the therapeutic effects of ECM/SVF-gel on healing and potential mechanisms. prepared use nude mouse excisional model. An SVF suspension phosphate-buffered saline injection served as control. expression levels endothelial growth...
Following initiation of China's National Malaria Elimination Action Plan in 2010, indigenous malaria infections Jiangsu Province decreased significantly. Meanwhile imported Plasmodium have increased substantially, particularly ovale and malariae. Given the risk for resurgence, there is an urgent need to understand increase P. malariae as China works achieve national elimination.An observational study cases Province, was carried out period 2011-2014.A total 1268 were reported from 2011 2014....
BACKGROUND The clinical outcomes of fat grafting vary and are technique-dependent. Stromal vascular fraction (SVF) gel is a novel, mechanically processed product with high concentrations adipose tissue–derived stem cells other SVF cells. This study evaluated the volumization rejuvenation effects SVF-gel. OBJECTIVE METHODS retrospective, single-center included 126 patients who underwent SVF-gel 78 conventional lipoinjection for various indications from March 2015 to February 2017. Patient...
Hypertrophic scars cause cosmetic and functional problems for patients, their treatment remains challenging. Mechanical micronization of adipose tissue can remove adipocytes concentrate cells. Stromal vascular fraction (SVF)-gel is obtained by a series simple mechanical processes, including shifting between syringes centrifugation. This study aimed to assess the therapeutic effect SVF-gel on hypertrophic scars. A model was established in rabbit ears. SVF cells were from inguinal fat pads...
Progressive hemifacial atrophy (Parry-Romberg disease) is rare and involves all skin layers subcutaneous soft hard tissue. Autologous fat grafting has revolutionized the field of soft-tissue reconstruction augmentation, but long-term maintenance unpredictable. Stromal vascular fraction (SVF)-supplemented cell therapy offers new hope for improving graft survival, with good results, efficacy outcome in clinic are rarely studied using objective data.To compare viability SVF-supplemented grafts...