A5050026123- Advanced Harmonic Analysis Research
- Advanced Mathematical Physics Problems
- Nonlinear Partial Differential Equations
- Mathematical Analysis and Transform Methods
- Holomorphic and Operator Theory
- Advanced Banach Space Theory
- Bladder and Urothelial Cancer Treatments
- Differential Equations and Boundary Problems
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Biosensors and Analytical Detection
- Immune Response and Inflammation
- Advanced Glycation End Products research
- Chronic Lymphocytic Leukemia Research
- Numerical methods in inverse problems
- Salmonella and Campylobacter epidemiology
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Fibroblast Growth Factor Research
- Colorectal Cancer Treatments and Studies
- Nanocluster Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
Chongqing Three Gorges University
2021-2025
Shenzhen Pingle Orthopedic Hospital
2024
Shanxi University
2013-2023
Janssen (United States)
2020-2023
Johnson & Johnson (United States)
2011-2023
Hubei Normal University
2016-2021
Shanxi University of Traditional Chinese Medicine
2016-2020
Wenzhou Hospital of Traditional Chinese Medicine
2016
State Council of the People's Republic of China
2016
Xinjiang University
2013-2014
Study Type – Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does study add? Hypermethylation genes such as glutathione‐S‐transferase P1 (GSTP1) adenomatous polyposis coli (APC) occurs with high frequency in prostate tumour tissue but is much less common benign prostate; however, potential value gene methylation biomarkers an adjunct to biopsy histopathology has had little study. When measured histologically tissue, APC hypermethylation was found...
In this paper, the authors first introduce a class of Orlicz-slice spaces which generalize slice recently studied by Auscher et al. Based on these spaces, then new kind Hardy-type Hardy via radial maximal functions. This scale contains variant Orlicz–Hardy space Bonami and Feuto as well Hardy-amalgam de Paul Ablé special cases. Their characterizations atom, molecule, various functions, Poisson integral Littlewood–Paley functions are also obtained. As an application characterizations,...
9013 Background: Amivantamab (ami) is a bispecific antibody targeting EGFR and MET with immune cell-directing activity, lazertinib (laz) brain-penetrant, third-generation tyrosine kinase inhibitor. In previous report, the overall response rate (ORR) of ami+laz in post-osimertinib (osi) setting was 36%, median duration 9.6 months (Bauml JCO 2021; 39:15_suppl, 9006). Exploratory analyses suggested certain immunohistochemistry (IHC) ctDNA-based next-generation sequencing (NGS) biomarkers may...
Enhancing tumor homing and improving the efficacy of drugs are urgent needs for cancer treatment.
Background: Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway plays an important role in sepsis, transducing a multitude inflammatory signals. To date, knowledge JAK/STAT sepsis is limited. This study was to investigate the potential mediating multiple organ damage mortality septic rats. Our data showed that inhibition JAK2/STAT3 attenuated cecal ligation puncture-induced 48 hours Methods: A total 98 male Wistar rats were randomly divided into 4 groups as...
A novel carbazole derivative, N,N′-bis(9-ethyl-9H-carbazol-3-yl)-(ethane-1,2-diamine), has been synthesized by reacting 3-amino-9-ethylcarbazole with glyoxal and characterized 1H NMR, infrared spectroscopy, elemental analysis mass spectra. The strong fluorescence emission at 438 nm of the derivative is effectively selectively quenched Cr3+. 1 : complex formed between Cr3+ their association constant 1.4 × 104 L mol−1. results indicate that can provide a rapid, selective sensitive response to...
The core–shell AuNCs synthesized by a facile strategy using NAC as reducing-cum-protecting agent were successfully applied for cancer cell imaging.
Naproxen enantiomers possess strong room temperature phosphorescence (RTP) in β-cyclodextrin (β-CD) system with a small amount of 1,2-dibromoethane (1,2-DBE) under ambient conditions. The effects pH, concentration β-CD, and 1,2-DBE on the RTP naproxen have been investigated detail. Time-resolved spectroscopy shows that both exhibit biexponential decay pattern lifetimes τ1 = 4.79 ± 0.13 τ2 1.51 0.096 ms for R-naproxen 6.67 0.15 2.13 0.061 S-naproxen. lifetime differences between these are Δτ1...
Echinomycin, a member of the quinoxaline family antibiotics, is known to be small-molecule inhibitor hypoxia inducible factor-1 (HIF-1) DNA binding activity. Recently, it has been shown suppress mammalian target rapamycin (mTOR) signaling and growth in leukemia cell lines. In this study, we investigated whether echinomycin interacts with FKBP12 protein. Molecular docking was used, predicted energy -10.61 kcal/mol. Moreover, surface plasmon resonance imaging fluorescence quenching techniques...
Abstract Erdafitinib, a pan‐fibroblast growth factor receptor (FGFR) inhibitor received accelerated approval from the US Food and Drug Administration (FDA) for locally advanced or metastatic urothelial carcinoma (mUC) in adult patients with specific FGFR3/2 genetic alterations who progressed during after ≥1 line of prior platinum‐containing chemotherapy (PCC), including within 12 months neoadjuvant adjuvant PCC. Concordance between clinical trial assay (CTA) used phase 2 study QIAGEN's...
We assessed the concordance between immunohistochemistry (IHC) and gene expression profiling (GEP) for determining diffuse large B-cell lymphoma (DLBCL) cell of origin (COO) in phase III PHOENIX trial rituximab plus cyclophosphamide, doxorubicin, vincristine prednisone (R-CHOP) with or without ibrutinib. Among 910 1114 screened patients non-germinal centre B cell-like (non-GCB) DLBCL by IHC, GEP non-GCB calls was 82·7%, 691 (75·9%) identified as activated (ABC), 62 (6·8%) unclassified. 746...
Amivantamab, an epidermal growth factor receptor (EGFR)–c-Met bispecific antibody, targets activating/resistance EGFR mutations and MET mutations/amplifications. In the ongoing CHRYSALIS study (ClinicalTrials.gov Identifier: NCT02609776), amivantamab demonstrated antitumor activity in patients with non–small cell lung cancer harboring exon 20 insertion (ex20ins) that progressed on or after platinum-based chemotherapy, a population which use has been approved by US Food Drug Administration....
Abstract In this post hoc subgroup analysis of 200 patients enrolled in China from the phase III PHOENIX trial ( N = 838, NCT01855750), addition ibrutinib to rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R‐CHOP) did not improve event‐free survival (EFS) versus placebo+R‐CHOP intent‐to‐treat (ITT; n 200, hazard ratio [HR] 0.83, 95% confidence interval [CI]: 0·509–1.349; p 0.4495) or activated B‐cell‐like (ABC; 141 [based on available gene‐expression profiling...
Abstract Background: The Qiagen therascreen® companion diagnostic is FDA approved to aid identifying patients with urothelial carcinoma who harbor susceptible fibroblast growth factor receptor (FGFR) gene alterations and are therefore eligible for treatment erdafitinib, an FGFR inhibitor. We examined analytical concordance between the assay against 2 next-generation sequencing (NGS) platforms used identify molecular targets tailored treatment, including alterations. Methods: Formalin-fixed...
This paper explains that setting up artificial intelligence courses can clearly enhance students' interest in high technology, boost learning confidence and promote overall development the following three aspects: significance of education to students, confusion regarding teaching this stage, especially rural middle schools, some related suggestions.