A5033748482- Advanced Control Systems Optimization
- Fault Detection and Control Systems
- Industrial Automation and Control Systems
- Process Optimization and Integration
- Sugarcane Cultivation and Processing
- Simulation Techniques and Applications
- Advanced Biosensing Techniques and Applications
- Smart Grid Energy Management
- Monoclonal and Polyclonal Antibodies Research
- Wind Energy Research and Development
- Virus-based gene therapy research
- Modeling and Simulation Systems
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Redox biology and oxidative stress
- Cancer therapeutics and mechanisms
- Mineral Processing and Grinding
- Genomics, phytochemicals, and oxidative stress
- Gene expression and cancer classification
- Spectroscopy and Chemometric Analyses
- Scheduling and Optimization Algorithms
- Microgrid Control and Optimization
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced biosensing and bioanalysis techniques
- Business Process Modeling and Analysis
Universidad de León
2025
Universidad de Burgos
2012-2024
Universidad de Valladolid
2005-2020
Universidad Publica de Navarra
2019
University of Chinese Academy of Sciences
2014-2015
National Center for Nanoscience and Technology
2012-2015
Instituto de Investigaciones Avícolas
2010-2013
Chinese Academy of Sciences
2012
University College Dublin
2006-2010
University of California, Los Angeles
1999-2000
Reliable and timely fault detection isolation are necessary tasks to guarantee continuous performance in complex industrial systems, avoiding failure propagation the system helping minimize downtime. Model-based diagnosis fulfils those requirements, has additional advantage of using reusable models. However, reusing existing non-linear models for large systems is not straightforward. Most times, have been created other purposes different from diagnosis, many times required analytical...
Rhamnogalacturonan–I (RG–I) pectin recovered from sugar beet pulp (SBP) and discarded red beetroot (DRB) were subjected to enzymatic hydrolysis obtain pectooligosaccharides (POS). The hydrolysates with the highest amount of oligomer a degree polymerization 2 6 selected for detailed characterization composition structure by MALDI-TOF MS 1H NMR. yields POS products ranged 32.7% (g DRB POS/g DRB) 37.0% SBP Pectin/g SBP) content 64.4% (DRB products) 68.7% (SBP POS). A comparative study was...
Abstract The role of the adenovirus major late upstream transcription factor (MLTF) in from and IVa2 promoters was studied. initiation site promoter is located 210 nucleotides CAP promoter. Transcription these two occurs on different DNA strands. Thus, this divergent suggests that same could simultaneously regulate expression genes. This investigated utilizing a reconstituted system vitro. addition MLTF to reaction mixtures containing purified general factors resulted 10-12-fold stimulation...
The isolation of a cellular factor that was specifically required for transcription from the promoter adenovirus early gene iv, an EIa-activated promoter, is described. This (EivF) purified HeLa cells using functional assay and identified as 72,000- to 65,000-dalton protein. DNase I footprinting experiments demonstrated EivF bound sequence 5'-GT(G/T)ACGT-3' present two times upstream Eiv TATA box. Nuclear extracts prepared contained more than one capable binding recognition site. Previous...
We have studied the protein factors that promote transcription via binding to cAMP response element (CRE) present in adenovirus early region III (EIII) and IV (EIV) promoters. Three sets of CRE-binding phosphoproteins, ranging molecular mass from 65-72, 38-43, 31-37 kDa, were identified vivo HeLa cells. Western blot analysis revealed all three proteins immunologically related factor AP1. found these CRE could be regulated by phosphorylation vitro. EivF, a 65-72-kDa was bind specifically EIV...
Calmodulin is an essential regulator of intracellular processes in response to extracellular stimuli mediated by a rise Ca(2+) ion concentration. To profile protein-protein interactions calmodulin human brain, we probed high content protein array with fluorophore-labeled the presence Ca(2+). This contains 37,200 redundant proteins, incorporating over 10,000 unique neural proteins from brain cDNA library. We designed screen find affinity (K(D) < or = 1 microm) binding partners and identified...
Human transcription factor IIA (TFIIA) is composed of three subunits (alpha, beta, and gamma). TFIIA interacts with the TATA-box binding protein can overcome repression transcription. was found to be necessary for VP16-mediated transcriptional activation through a coactivator function. We have separated antirepression activities TFIIA. A lacking alpha subunit isolated from HeLa cells. This "mini-TFIIA" transcription, but it defective in
Este trabajo se enmarca en el desarrollo de gemelos digitales ámbito la generación energía mediante parques eólicos. Para desarrollar estos y aplicarlos a distintos reales, uno los problemas que aparece es existencia una gran variedad turbinas eólicas con distintas características. Normalmente fabricantes proporcionan información muy limitada, entre datos suelen suministrar, está curva potencia-viento. Sin embargo, parámetros clave modelado matemático turbina coeficiente potencia, sobre todo...
Peroxiredoxin (Prx)-I and -II belong to a new class of antioxidants. Here, we report that they are induced by ischemia/reperfusion (I/R) in transplanted livers. Hypothesizing Prxs protect liver from oxidative damage, transduced these human genes into murine NIH-3T3 cells. The overexpressed made the cells more resistant t-butylhydroperoxide-induced apoptosis. These results indicate Prx-I Prx-II transplantation process can against oxidant damage tissue culture. Thus, proper genetic...