A5100619432- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Biomedical Research and Pathophysiology
- Nuclear Structure and Function
- Hepatitis B Virus Studies
- Cardiomyopathy and Myosin Studies
- Immune cells in cancer
- Economic and Financial Impacts of Cancer
- Bacteriophages and microbial interactions
- Prenatal Screening and Diagnostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Genetic and Kidney Cyst Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Pediatric Hepatobiliary Diseases and Treatments
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- interferon and immune responses
- Protein Interaction Studies and Fluorescence Analysis
- Connective tissue disorders research
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Breast Lesions and Carcinomas
First Affiliated Hospital of Jinan University
2019-2023
Massachusetts General Hospital
2016
Intratumoral immunotherapeutic hydrogel administration is emerging as an effective method for inducing a durable and robust antitumor immune response. However, scaffold hydrogels that can synergize with the loaded drugs, thus potentiating therapeutic efficacy, are limited. Here, we report ternary composed of polyvinyl alcohol (PVA), polyethylenimine (PEI)‒a cationic polymer potential immunoactivation effects, magnesium ions‒a stimulator adaptive response, which exhibits intrinsic...
To identify the novel, noninvasive biomarkers to assess outcome and prognosis of breast cancer (BC), patients with high sensitivity specificity are greatly desired. Herein, miRNA expression profile matched clinical features BC were extracted from The Cancer Genome Atlas (TCGA) database. preliminary candidates screened out by univariate Cox regression test. Then, help LASSO analysis, hsa-let-7b, hsa-mir-101-2, hsa-mir-135a-2, hsa-mir-22, hsa-mir-30a, hsa-mir-31, hsa-mir-3130-1,...
Abstract Background Centronuclear myopathy (CNM), a subtype of congenital (CM), is group clinical and genetically heterogeneous muscle disorders. kind disease difficult to diagnose due its genetic diversity. Since the discovery SPEG gene disease‐causing variants, only few additional patients have been reported. Methods A radiograph test, ultrasonic biochemical tests were applied diagnosis CNM. We performed trio medical exome sequencing family conservation analysis identify variants. Results...
Progressive familial intrahepatic cholestasis (PFIC) is an autosomal recessive inherited disease that accounts for 10%-15% childhood and could lead to infant disability or death. There are three well-established types of PFIC (1-3), caused by mutations in the ATP8B1, ABCB11, ABCB4 genes. Biallelic pathogenic variants tight junction protein 2 gene (TJP2) were newly reported as a cause type 4; however, only limited number patients undisputable have been TJP2, underlying mechanism 4 remains...
BACKGROUND:Novel biomarkers provide clinicians more critical information on tumor genetic features and patients' prognosis. Here, we aimed to establish prognosis-predicting signatures for endometrial carcinoma (EC) patients based the miRNA information. MATERIAL AND METHODS:The Cancer Genome Atlas (TCGA) website was available dataset extraction. Prognosis-associated miRNAs were generated by univariate Cox regression test. Online websites used predict targeted genes of these enrolled miRNAs....
Selenium nanoparticle (SeNP)-based nanotherapeutics have become an emerging cancer therapy, while effective drug delivery remains a technical hurdle. A theranostic approach, through which imaging companions are integrated with SeNPs, will allow image-guided and, therefore, is highly desirable. Traditional methods require the chemical conjugation of agents to surface nanoparticles, may impede later clinical translation. In this study, we developed label-free strategy in...
Abstract Background : CLIFAHDD is caused by mutation in NALCN and characterized facial malformation, hypotonia, developmental delay. Recently rare mutations associated with of syndrome have been reported. Methods Whole exome sequencing (WES) was applied to a diagnosis suspected proband based on clinical symptoms. Blood samples were taken from the parents for co-segregation analysis using Sanger sequencing. In addition, prenatal gene performed family. Finally bioinformatics utilized predict...
Abstract Objective: To compare multiple breast cancer screening methods for evaluating non-mass-like lesions (NMLs) and to investigate the best method (NMLs). Methods: This retrospective study examined 253 patients aged 24 68 years who were diagnosed with NMLs from April 2017 December 2019. All evaluated by MG, HHUS, ABUS determine BI-RADS classification, underwent pathological examination within six months or at least 2 of follow-up. The sensitivity, specificity, accuracy, positive...
Abstract Background: CLIFAHDD is caused by mutation in NALCN and characterized facial malformation, hypotonia, developmental delay. Recently rare mutations associated with of syndrome have been reported. Methods: Whole exome sequencing (WES) was applied to a diagnosis suspected proband based on clinical symptoms. Blood samples were taken from the parents for co-segregation analysis using Sanger sequencing. In addition, prenatal gene performed family. Finally bioinformatics utilized predict...