A5101893182- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive natural compounds
- Retinal Diseases and Treatments
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Cholinesterase and Neurodegenerative Diseases
- RNA modifications and cancer
- Glaucoma and retinal disorders
- Ubiquitin and proteasome pathways
- Adenosine and Purinergic Signaling
- Chemical Synthesis and Analysis
- Advanced biosensing and bioanalysis techniques
- Insect Resistance and Genetics
- Neural dynamics and brain function
- Fungal and yeast genetics research
- Plant-based Medicinal Research
- BRCA gene mutations in cancer
- Advanced Glycation End Products research
- Plant pathogens and resistance mechanisms
University of Jinan
2025
Shanghai Jiao Tong University
2017-2024
Ruijin Hospital
2020-2024
Fudan University
2022-2024
Huadong Hospital
2022-2024
Shanghai First People's Hospital
2021
Shanghai Eye Disease Prevention & Treatment Center
2021
Sichuan Cancer Hospital
2014-2017
China Pharmaceutical University
2008-2015
University of Szeged
2015
Telmisartan, a member of the angiotensin II type 1 receptor blockers, is usually used for cardiovascular diseases. Recent studies have showed that telmisartan has property PPARγ activation. Meanwhile, essential tumor proliferation, invasion and metastasis. In this work we explore whether could exert anti-tumor effects through activation in A549 cells. MTT trypan blue exclusion assays were included to determine survival rates cell viabilities. RT-PCR western blotting analyze expression...
Background: Oxidative stress-related apoptosis is considered as the key mechanism implicated in pathophysiology of nephrotoxicity with vancomycin (VCM) therapy. We evaluated possible effects N-acetylcysteine (NAC) on VCM-induced and underlying mechanism. Methods: was established using HK-2 cells SD rats observed by measuring cell survival, kidney histological changes, renal function injury related markers (KIM-1 NGAL). stress, involved signaling pathways were also evaluated. Results: In...
Diabetic retinopathy (DR), a neurovascular disease, is one of the leading causes blindness in working-age adults. Long noncoding RNAs (lncRNAs) have attracted attention as indicators for DR. This study aimed to characterize role lncRNA human testis development-related gene 1 (TDRG1) and its modulation vascular endothelial growth factor (VEGF) deteriorating DR.Tissue samples were obtained from patients with epiretinal membranes (EMs) or proliferative DR, retinal microvascular cells (HRECs)...
The role of histone deacetylases 6 (HDAC6) has been elucidated in various neurodegenerative diseases. However, the effect HDAC6 on retinal degenerative processes remains unknown. aim this study was to elucidate potential ischaemia and reperfusion (I/R) injury model.The pathological lesion evaluated by haematoxylin eosin (H&E) staining. HDAC expression or activity detected immunohistochemistry, Western blotting assays colorimetric assays. apoptotic- autophagic- related proteins were...
Glaucoma is a neurodegenerative disease that shares similar pathological mechanisms with Alzheimer's (AD). Drug treatments for glaucoma increasingly rely upon both lowering of intraocular pressure (IOP) and optic nerve protection, as IOP alone has been unsatisfactory. Huperzine A (HupA) an acetylcholinesterase inhibitor (AChEI) used AD. This study investigated the potential HupA treatment glaucoma.The ability to lower via causing pupil constriction was assessed using New Zealand rabbits. The...
Abstract Two new, i.e. , 1 and 2 69 known phenolics were isolated from the aerial parts of Abies nephrolepis. These chemical constituents included 22 lignans, 30 flavonoids, 19 other phenols. Their structures determined mainly by analysis 1D‐ 2D‐NMR spectroscopic data. All 71 isolates evaluated for their inhibitory activities against lipopolysaccharide (LPS)‐induced NO production in RAW 264.7 macrophages. Compound exhibited a potent effect with an IC 50 value 13.7 μg/ml.
Histone deacetylase (HDAC) 2 plays a vital role in modifying histones to mediate inflammatory responses, while HDAC2 itself is commonly regulated by post-translational modifications. Small ubiquitin-related modifier (SUMO), as an important PTM factor, involved the regulation of multiple protein functions. Our previous studies have shown that carbocisteine (S-CMC) reversed cigarette smoke extract (CSE)-induced down-regulation expression/activity thiol/GSH-dependent manner and enhanced...
From the aerial part of <i>Abies recurvata</i>, 62 miscellaneous chemical constituents were isolated including 6 new and 56 known ones. The compounds comprised three monoterpenes, two diterpenes, one lignan. Their structures characterized on basis various spectroscopic techniques. Dihydrodehydrodiconiferyl alcohol (<b>35</b>) showed strongest inhibitory effects against lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells with an IC<sub>50</sub> value 66.4 µM.
Plackett-Burman design and response surface methodology were employed to optimize the medium components for endochitinase production by Pichia pastoris . A Plackett- Burman of seven factors with 12 runs was applied evaluate effects different medium components. Yeast extract, oleic acid Tween-80 found have significant influence on production. The optimal concentrations three factors investigated using Box- Behnken design. The optimal components obtained achieving maximum activity of the as...
Abstract A systematic phytochemical investigation on Abies forrestii afforded two new and 20 known compounds. Abieseconordines B ( 1 2 ) are the first examples of norditerpenes with a novel 18‐nor‐5,10 : 9,10‐disecoabietane skeleton. Their structures were established mainly by analysis 1D‐ 2D‐NMR spectroscopic data. In addition, electronic circular‐dichroism calculations molecular‐orbital utilized to confirm absolute configuration . Both compounds exhibited potent effect in bioassay...
Muscarinic acetylcholine receptor (mAChR) agonists have been used to treat glaucoma due their intraocular pressure-lowering effects. Recently, it has reported that retinal mAChRs activation can also stimulate neuroprotective pathways.In our study, we evaluated the potential effect of L-satropane, a novel mAChR agonist, on neuronal injury induced by cobalt chloride (CoCl2) and ischemia/reperfusion (I/R).CoCl2-induced hypoxia in cultured cell models I/R-induced damage rats vivo were evaluate...
To quantify the levels of three inflammatory cytokines in aqueous humour patients with prior acute primary angle closure (APAC) and investigate their correlation surgical outcomes trabeculectomy.In this prospective cohort study, samples were collected from 44 APAC eyes. Analyte concentrations monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF) interleukin-6 (IL-6) measured using multiplexed immunoassay kits. Intraocular pressure was Goldmann application...
Flap endonuclease 1 (FEN1) is closely associated with tumor progression and proliferation, making it a promising biomarker for cancer diagnosis. However, developing sensitive, reliable, user-friendly method quantitative FEN1 detection remains technically challenging. In this study, an ultrasensitive biosensor established using target-induced cleavage-ligation-transcription-activation cascade strategy (LTACas13a) to enhance the cleavage ability of CRISPR/Cas13a. The LTACas13a has shown...
牛荣荣 1 于 萍 王玮文 2 ( 北京市"学习与认知"重点实验室; 首都师范大学心理学院, 北京 100048) 中国科学院心理健康重点实验室, 中国科学院心理研究所, 100101) 摘 要 注意缺陷多动障碍(attention deficit/hyperactivity disorder, ADHD)行为控制不足与决策冲动密切相关, 后 者受内侧前额皮层(medial prefrontal cortex, mPFC)与伏隔核(nucleus accumbens, NAc)调节。 为调查 ADHD 决策冲动 与 mPFC-NAc 间功能耦合的关系, 研究采用 模型 SHR (spontaneously hypertensive rat, SHR)大鼠, 结合延迟 折扣任务和在体电生理, 研究发现, 与对照 Wistar (WIS)大鼠相比, 大鼠对延迟大奖赏的选择百分比降低; WIS 大鼠 的 Theta 频段相干值表现为延迟选择时显著大于立即选择时、首次选择时大于连续选择时、转换 试次时大于连续试次时, 而 大鼠在上述条件均低于 大鼠。回归分析发现 的相干差值与延迟...