A5101624539- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Microbial Natural Products and Biosynthesis
- Epigenetics and DNA Methylation
- Adenosine and Purinergic Signaling
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Molecular Biology Techniques and Applications
- Genomics and Chromatin Dynamics
- Chemical Reactions and Isotopes
- Histone Deacetylase Inhibitors Research
- Pneumonia and Respiratory Infections
- Retinal Diseases and Treatments
- Gene expression and cancer classification
China Pharmaceutical University
2025
Shanghai Jiao Tong University
2018-2020
Ruijin Hospital
2018
Institute of Forensic Science
2015
Initially isolated in 1950 from a Streptomyces strain, macrolides have evolved to address chronic lung inflammatory diseases and respiratory tract infections. However, with the emergence of bacterial resistance, there is an urgent need for new antibiotics alleviate current situation. The structure characterized by macrocyclic lactone ring 14, 15, or 16 atoms, often linked sugars via glycosidic bonds. mode action involves inhibiting protein synthesis binding ribosome, though recent studies...
Our study aimed to identify the underlying causes in patients with early onset dementia by clinical and genetic exploration. We recruited a group of 38 early-onset dementia. Firstly, hexanucleotide repeat expansions <i>C9ORF72</i> gene were screened all subjects exclude possibility copy number variation. Then, whole exome sequencing (WES) was conducted, data analyzed focusing on 89 dementia-related causing susceptible genes. The effects identified variants classified according American...
The role of histone deacetylases 6 (HDAC6) has been elucidated in various neurodegenerative diseases. However, the effect HDAC6 on retinal degenerative processes remains unknown. aim this study was to elucidate potential ischaemia and reperfusion (I/R) injury model.The pathological lesion evaluated by haematoxylin eosin (H&E) staining. HDAC expression or activity detected immunohistochemistry, Western blotting assays colorimetric assays. apoptotic- autophagic- related proteins were...
Abstract Klebsiella pneumoniae is a common pathogen associated with nosocomial infections and characterised serologically by capsular polysaccharide (K) lipopolysaccharide O antigens. We surveyed total of 348 non-duplicate K. clinical isolates collected over 1-year period in tertiary care hospital, determined their K serotypes sequencing the wbb Y wzi gene loci, respectively. Isolates were also screened for antimicrobial resistance hypervirulent phenotypes; 94 (27.0%) identified as...
An experimental model of male-mixed DNA (n=297) was constructed according to the mixed construction principle. This comprised use Applied Biosystems (ABI) 7500 quantitative polymerase chain reaction system, with scientific validation mixture proportion (Mx; root‑mean‑square error ≤0.02). Statistical analysis performed on locus separation accuracy using mixsep, a R‑package, and analytical performance mixsep assessed by examining data distribution pattern different gradients, short tandem...