Z Y Zhang

ORCID: 0000-0003-4283-521X
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About
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Research Areas
  • Probiotics and Fermented Foods
  • Gut microbiota and health
  • Vascular Malformations and Hemangiomas
  • Mycobacterium research and diagnosis
  • Cancer Cells and Metastasis
  • Oral and Maxillofacial Pathology
  • Genomics and Phylogenetic Studies
  • Oral microbiology and periodontitis research
  • Nanocluster Synthesis and Applications
  • Cardiac Fibrosis and Remodeling
  • Global Public Health Policies and Epidemiology
  • Tumors and Oncological Cases
  • Central Venous Catheters and Hemodialysis
  • Biopolymer Synthesis and Applications
  • Salivary Gland Disorders and Functions
  • Traditional Chinese Medicine Studies
  • Child and Adolescent Health
  • Advanced Nanomaterials in Catalysis
  • Tuberculosis Research and Epidemiology
  • Biological and pharmacological studies of plants
  • Herbal Medicine Research Studies
  • Phytochemistry and Biological Activities
  • Dental Health and Care Utilization
  • Vascular anomalies and interventions
  • Polyoxometalates: Synthesis and Applications

Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025

Fuzhou University
2024

Shanghai Ninth People's Hospital
2010-2023

Shanghai Jiao Tong University
2009-2023

Beijing Tsinghua Chang Gung Hospital
2021

Tsinghua University
2021

Lactobacillus plantarum is a lactic acid bacterium (LAB) species commonly used as probiotic. We have sequenced the genome of JDM1, which Chinese commercial LAB with several probiotic functions, using GS 20 system. recommend that each strain should undergo complete sequencing to ensure safety and stability.

10.1128/jb.00587-09 article EN Journal of Bacteriology 2009-05-23

Abstract Meisoindigo (Mei) has been clinically utilized for the treatment of chronic myeloid leukemia (CML), yet precise molecular targets by which it exerts effects remain unclear. Through activity‐based protein profiling (ABPP), kinase, membrane‐associated tyrosine/threonine 1 (PKMYT1) is identified as a direct target Mei. Specifically, Mei forms selective and reversible covalent bond with Cys301 residue PKMYT1, triggering its K48‐linked polyubiquitination accelerating proteasomal...

10.1002/advs.202413676 article EN cc-by Advanced Science 2025-04-25

Venous malformation (VM) is the most common symptomatic low-flow vascular malformation, which predominantly occurs in head and neck region. The aim of this paper was to evaluate results endovascular sclerotherapy voluminous VM, when lesion either >or=15 cm maximum diameter or invades more than one anatomical space, region using absolute ethanol under digital subtraction angiography (DSA) guidance.A total 23 patients with VMs between October 2005 December 2008 were retrospectively reviewed....

10.1258/phleb.2009.009019 article EN Phlebology The Journal of Venous Disease 2010-05-17

Bifidobacteria, known as probiotic bacteria, are high-G+C Gram-positive bacteria which naturally inhabit the human gastrointestinal tract and vagina. Recently, we completely sequenced Bifidobacterium longum JDM301, is a widely used Chinese commercial strain with several properties.

10.1128/jb.00538-10 article EN Journal of Bacteriology 2010-06-05

Comprehensive research on ethnic disparities in dental caries China is limited. The aims of this cross-sectional study were to compare the levels adolescents between Han group and minority groups explore risk indicators for within subgroups. Data from Fourth National Oral Health Survey 2015, which covered all 31 province-level administrative divisions mainland China, used. status permanent dentition aged 12, 13, 14, 15 y was measured using decayed, missing, filled teeth (DFMT) score,...

10.1177/0022034520976541 article EN Journal of Dental Research 2020-12-07

Sepsis-induced myocardial dysfunction (SIMD) leads to poor prognosis or even death in severe sepsis cases, therefore, exploring its pathogenesis and new therapeutic targets has become the focus of current research. Specifically, an SIMD rat model was constructed by cecal ligation puncture (CLP) method. At 24 h after intraperitoneal injection NLRP3 selective inhibitor MCC950, levels serum cardiac troponin I (cTnI) Lactate dehydrogenase (LDH) were detected, function rats examined via...

10.23812/20-662-a article EN Journal of Biological Regulators and Homeostatic Agents/Journal of Biological Regulators & Homeostatic Agents 2021-02-28

Integrating Fenton chemistry and nanomedicine into cancer therapy has significantly promoted the development of chemodynamic (CDT). Nanoscale polyoxometalates (POMs), with their reversible redox properties, exhibit promising potential in developing outstanding CDT drugs by exploring Fenton‐like catalytic reactivity tumor environments. However, such research is still its infancy. In this work, we report synthesis a new crystalline antimonotungstate {Dy2Sb2W7O23(OH)(DMF)2(SbW9O33)2} (1, DMF =...

10.1002/anie.202422949 article EN Angewandte Chemie International Edition 2024-12-16

Mycobacteriosis is on the increase. Nontuberculous mycobacteria (NTM) are resistant to most antituberculosis drugs naturally. We determined complete genome sequence of a novel NTM strain, JDM601, Mycobacterium terrae complex, which was isolated from patient with tuberculosis-like disease and various antibiotic resistances.

10.1128/jb.05291-11 article EN Journal of Bacteriology 2011-06-18

Aim. The study was conducted to investigate the antibacterial and antiasthmatic effects of Nandina domestica leaf extract, find out its active components, assess safety issue. Methods . (1) Solid-phase agar dilution method used for activity test nandina extract change bacterial morphology after treatment observed under transmission microscope; (2) guinea pig model asthma prevention effect extract; (3) alkaloids flavones were separated from further analyzed with HPLC-MS; (4) mice assessment...

10.1155/2018/8298151 article EN Evidence-based Complementary and Alternative Medicine 2018-01-01

Abstract Klebsiella pneumoniae is a common pathogen associated with nosocomial infections and characterised serologically by capsular polysaccharide (K) lipopolysaccharide O antigens. We surveyed total of 348 non-duplicate K. clinical isolates collected over 1-year period in tertiary care hospital, determined their K serotypes sequencing the wbb Y wzi gene loci, respectively. Isolates were also screened for antimicrobial resistance hypervirulent phenotypes; 94 (27.0%) identified as...

10.1017/s0950268820001788 article EN cc-by-nc-nd Epidemiology and Infection 2020-01-01

Objectives: To investigate the clinical symptoms, computed tomography (CT) features and treatments of intraosseous venous malformations (IVM) that occur in facial bone. Methods Results: Eleven patients with IVM were treated two surgical techniques, excision ( n = 4) or curettage 7). No recurrence was encountered at follow-up (45.8 ± 16.0 months). Postoperative deformities left paediatric who excision. Conclusions: The diagnosis can be difficult is mainly based on symptoms CT features. should...

10.1258/phleb.2011.011115 article EN Phlebology The Journal of Venous Disease 2012-03-19

Objective: To determine the correlation between diabetes mellitus control and periodontitis. Methods: This study was a cross-sectional survey using stratified system sampling model design. The target population patients with investigated from May to July 2018 in Huangpu District of Shanghai. In present study, severe periodontitis defined as at least two sites different quadrants probing depth (PD)≥6 mm clinical attachment loss (CAL)≥ 5 mm. Edentulous induced by were also classified others...

10.3760/cma.j.cn112144-20210128-00045 article EN 2021-06-09

As the national key discipline and initiator of oral maxillofacial deformity group, Department Oral Maxillofacial Surgery persisted in teaching, designed a novel teaching form combining theoretical knowledge online software practice according to characteristics our carried out cloud training via National Telemedicine Education Platform. Ten lecturers, 325 students 50 practical were investigated by questionnaire present study with questions focusing on geographical distribution composition...

10.3760/cma.j.cn112144-20200629-00380 article EN 2021-02-09
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