A5101612214- Nitric Oxide and Endothelin Effects
- Burkholderia infections and melioidosis
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- SARS-CoV-2 and COVID-19 Research
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Animal Virus Infections Studies
- Autophagy in Disease and Therapy
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- Academic Publishing and Open Access
- Electrolyte and hormonal disorders
- Cerebral Venous Sinus Thrombosis
- Regional Economic and Spatial Analysis
- Menstrual Health and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- E-commerce and Technology Innovations
- Carcinogens and Genotoxicity Assessment
- Hepatitis C virus research
- Chronic Myeloid Leukemia Treatments
- Sphingolipid Metabolism and Signaling
- Lipid metabolism and biosynthesis
- Customer Service Quality and Loyalty
Nanjing Medical University
2024
Beijing Friendship Hospital
2023-2024
Capital Medical University
2017-2024
Tianjin haihe hospital
2023-2024
Tianjin Medical University
2023-2024
Second Hospital of Tianjin Medical University
2023-2024
Jinan University
2023
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2023
Tianjin University
2023
Loma Linda University
2014-2022
Zinc oxide nanoparticles (ZnO NPs) have been extensively used in various industries and reported to inhibit spermatogenesis, however, ZnO NPs-induced spermatogenesis failure is yet be fully elucidated. Herein, mouse-derived spermatogonia cell line GC-1 spg cells were treated with NPs for 24 h the presence or absence of radical scavenger N-acetyl-L-cysteine (NAC) autophagy inhibitor 3-methyladenine (3-MA), then viability was observed by MTT assay; apoptosis western blotting analysis...
As one of the most frequently produced synthetic compounds worldwide, bisphenol A (BPA) has been widely used in many kinds products such as appliances, housewares, and beverage cans. BPA shown to cause damage male reproductive system; however, potential mechanism remains be investigated. In present study, exposure decreased testis epididymis coefficient, caused a disintegration germinal epithelium, density motility sperm tissue, increased number abnormal morphology, which indicated that...
Abstract One marker of arterial stiffness (AS) is the brachial-ankle pulse wave velocity (baPWV). We aim to investigate predictive value baPWV with regard new-onset atrial fibrillation (AF). All participants without AF from 2010 2020 in Kailuan cohort were included. The primary endpoint was AF. Participants categorized into three study groups based on baPWV, a normal group as reference. analyzed continuous variable. Multivariable Cox proportional hazard regression models used association. A...
Introduction Pseudomonas aeruginosa is present throughout nature and a common opportunistic pathogen in the human body. Carbapenem antibiotics are typically utilized as last resort clinical treatment of multidrug-resistant infections caused by P. . The increase carbapenem-resistant poses an immense challenge for these infections. Bacteriophages have potential to be used antimicrobial agents treating antibiotic-resistant bacteria. Methods Results In this study, new virulent phage,...
Online medical consultation (OMC) is generating considerable interest among researchers and practitioners due to the mandatory quarantine measures implemented during COVID-19 pandemic in China. However, acceptance rate of OMC has declined over time. This paper aims empirically investigate using a proposed research model by integrating technology (TAM) with trust its antecedent variables. A quantitative self-administered cross-sectional survey was conducted collect data from 260 healthcare...
Ducks infected with duck circovirus (DuCV) show symptoms such as feather loss, growth retardation and low body weight in the flock. The virus induces immunosuppression increases prevalence of infection other pathogens. However, most studies on were focused co-infection, fewer had been conducted pathogenicity alone. aim present study was to investigate pathogenesis DuCV-1 experimentally specific pathogen-free ducks. In this study, we sequenced whole genome a strain identified genotype...
Severe acute exacerbation in patients with chronic hepatitis B is a unique clinical presentation that results high mortality. To compare the efficacy of 4 weeks entecavir or lamivudine therapy severe caused by B, 65 were retrospectively analyzed. The groups received 0.5 mg (group A) 100 B) daily. After treatment, virological and biochemical responses deterioration rates determined. average age alanine aminotransferase (ALT), bilirubin, albumin, creatinine (Cr), HBV DNA levels similar A prior...
Recently, With the development of global agricultural industrialization, modern agriculture has functions improving quality ecological environment and providing people with sightseeing, leisure, vacation. How to take user as center combine user’s personalized characteristics offer rural tourism products they need become a research problem real-world application value challenge. In this context, study develops an intelligent recommendation model by extensively analyzing contents information...
Lysophosphatidylcholine (LPC), a major class of glycerophospholipids ubiquitously present in most tissues, plays dominant role many diseases, while it is still unknown about the potential mechanism LPC affecting testicular Leydig cells. In study, mouse TM3 cells vitro were treated with for 48 h. was found to significantly induce apoptosis and oxidative stress cells; inhibition by N-acetyl-L-cysteine, an inhibitor stress, could rescue induction apoptosis, indicating that induced via stress....
Background Atrial fibrillation (AF) is a prevalent issue among critically ill patients, and the availability of effective treatment strategies for AF limited. Aim The objective this study was to evaluate mortality rate associated with in patients who were either aspirin or non-aspirin users. Methods This cohort incorporated from Medical Information Mart Intensive Care database. compared incidences 28-day mortality, 90-day 1-year between without prescriptions. To assess association endpoints,...
Background: Immunothrombosis is a physiological process that constitutes an intravascular innate immune response. Abnormal immunothrombosis can lead to thrombotic disorders. With the outbreak of COVID-19, there increasing attention mechanisms and its critical role in events, growing number relevant research papers are emerging. This article employs bibliometrics discuss current status, hotspots, trends this field. Methods: Research published from January 1, 2003, May 29, 2023, were collected...
Abstract The suppressive micro-environment within tumors is partly caused by infiltrating macrophages. Expression of HLA-G on tumor cells and its receptor LILRB2 macrophages are associated with poor prognosis in cancer patients. Anti antibodies have been developed to block interaction promote M1 macrophage differentiation. Whether anti antibody can exert effect through an independent mechanism has not investigated. Here, we describe PSB120, a fully humanized high affinity without...
Abstract SKLB1028 is a novel multi‐target protein kinase inhibitor under investigation for the treatment of FLT3‐ITD mutated acute myeloid leukemia. Based on preclinical characterization metabolism, three drug–drug interaction clinical studies were performed to investigate effects itraconazole, rifampin (CYP3A4 and inducer, respectively), gemfibrozil (CYP2C8 inhibitor) metabolism SKLB1028. Fourteen healthy Chinese male subjects enrolled in each study. In Study 1, administered single dose...
Rationale: Gastric mucosal ulcer caused by drug overdose is very rare in clinical practice, and here a case of gastric antral overdose. Patient concerns: A 35-year-old housewife from mountainous region China took 48 Ibuprofen Sustained-Release capsules (300 mg/capsule) orally at 1 time. Because severe tingling the upper abdomen accompanied sharp increase blood pressure, she came to doctor hours later. Diagnoses: (multiple stage A1), duodenococcitis, chronic nonatrophic gastritis,...
Abstract Background and Aims New‐onset atrial fibrillation (NOAF) is a common manifestation in critically ill patients. There paucity of evidence indicating relationship between urinary ketones NOAF. Methods Critically patients with ketone measurements from the Medical Information Mart for Intensive Care (MIMIC‐IV) database were included. The primary outcome was NOAF Propensity score matching performed following by multivariable logistic regression. Results A total 24,688 available data...
The 2019 novel coronavirus is a new of the beta genus and defined as category B infectious disease, prevented A disease. infection causes diversity clinical manifestations, including fever, dry cough, shortness breath, muscle soreness etc. infected are believed to be principal source infection, asymptomatic individuals who infected. Droplet transmission contact considered major route influenza spread. In some condition, aerosol works well. Alimentary tract remains confirmed. Most treatment...
With the gradual acceleration of urban transformation, characteristic towns in revolutionary areas have received great attention as a new carrier for development urbanization. It is critical to conduct thorough and complete evaluation unique town project take appropriate corresponding measures ensure project’s success. This study presents important policy aspects that determine long-term evolution projects based on theoretical examination their construction. Based this, this builds combines...
Elevated levels of the inflammatory marker interleukin-6 (IL-6) and cardiac injury N-terminal pro-B-type natriuretic peptide (NT-proBNP) have been observed in patients with coronavirus disease 2019 (COVID-19). However, relationship between IL-6 NT-proBNP remains unclear. Therefore, we investigated COVID-19.This was a cross-sectional study. Consecutive COVID-19 were included herein. The independent dependent target variables levels, respectively, measured at baseline. Univariate multivariate...
Abstract Epidemiological studies have revealed a correlation between diabetes mellitus and elevated blood glucose levels with atrial fibrillation (AF). Blood were assessed in critically ill patients to determine whether they correlate 28-day mortality. This study incorporated cohort of 13,105 diagnosed AF from MIMIC-IV database. Both smooth curve analysis cox proportional hazards regression employed. The selected participants had mean age 73.7 ± 11.7 years, an estimated 58.6% being male....