A5101870672- Autophagy in Disease and Therapy
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Cancer-related molecular mechanisms research
- Regulation of Appetite and Obesity
- Genetic Mapping and Diversity in Plants and Animals
- Nanoparticle-Based Drug Delivery
- Biochemical Analysis and Sensing Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Reproductive System and Pregnancy
- Plant Disease Resistance and Genetics
- Lipid metabolism and biosynthesis
- Phytochemicals and Antioxidant Activities
- Plant Virus Research Studies
- Microplastics and Plastic Pollution
- Circular RNAs in diseases
- Effects and risks of endocrine disrupting chemicals
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Kruppel-like factors research
- Cannabis and Cannabinoid Research
- Polyamine Metabolism and Applications
Shandong Agricultural University
2025
Chinese Academy of Agricultural Sciences
2021-2025
Farmland Irrigation Research Institute
2025
Shihezi University
2024
Nanchang University
2013-2024
Gansu Agricultural University
2019-2024
ZheJiang Academy of Agricultural Sciences
2019-2024
Dongyang People's Hospital
2017-2024
Jiangsu Yonggang Group (China)
2024
Wenzhou Medical University
2017-2024
Eggplant (Solanum melongena L.) is an economically important vegetable crop in the Solanaceae family, with extensive diversity among landraces and close relatives. Here, we report a high-quality reference genome for eggplant inbred line HQ-1315 (S. melongena-HQ) using combination of Illumina, Nanopore 10X genomics sequencing technologies Hi-C technology assembly. The assembled has total size ~1.17 Gb 12 chromosomes, contig N50 5.26 Mb, consisting 36,582 protein-coding genes. Repetitive...
Zinc oxide nanoparticles (ZnO NPs) have shown adverse health impact on the human male reproductive system, with evidence of inducing apoptosis. However, whether or not ZnO NPs could promote autophagy, and possible role autophagy in progress apoptosis, remain unclear. In current study, vitro vivo toxicological responses were explored by using a mouse model Leydig cell line. It was found that intragastrical exposure to mice for 28 days at concentrations 100, 200, 400 mg/kg/day disrupted...
Radish ( Raphanus sativus L.) is a vegetable crop with economic value and ecological significance in the genus Radish, family Brassicaceae . In recent years, developed countries have attached great importance to collection conservation of radish germplasm resources their research utilization, but lack population genetic information molecular markers has hindered development breeding radish. this study, we integrated genomic data published databases for single-nucleotide polymorphism (SNP)...
Eggplant (Solanum melongena; 2n = 24) is an economically important fruit crop of the family Solanaceae that was domesticated in India and Southeast Asia. Construction a high-resolution genetic map map-based gene mining eggplant have lagged behind other crops within such as tomato potato. In this study, we conducted high-throughput single nucleotide polymorphism (SNP) discovery genome using specific length amplified fragment (SLAF) sequencing constructed high-density for quantitative trait...
Di-isononyl phthalate (DINP) has been widely utilized in industrial, commercial and medical applications for the past few years. Therefore, more attention should be paid to toxicity of DINP. DINP can cause damage female reproductive system; however, potential mechanism remains further investigated. In this study, mice were orally administered with 0, 2, 20 200 mg DINP/kg/day 14 days. We found that significantly affected arrangement granulosa cells ovarian follicles. addition, could induce...
Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity animals humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that exposure for 14 consecutive days led serious hepatocellular injury obvious inflammatory cell infiltration. addition, malondialdehyde formation hydrogen peroxide generation, indicators oxidative stress, significantly...
As a plasticizer, plastic softener, and flame-retardant, tri-ortho-cresyl phosphate (TOCP) is has been widely used in industry reported to have toxic effect on the male reproductive system animals besides neurotoxicity immunotoxicity. We that TOCP inhibits spermatogenesis induces autophagy of rat spermatogonial stem cells, but it still unknown whether mouse Leydig cells its potential mechanism.Cell viability was observed by MTT assay. Level testosterone measured radioimmunoassay. Apoptosis...
Abstract Circular RNA (circRNA) is a newly discovered non-coding RNA, which play significant roles in the function and transcriptional regulation of microRNA. To date, Chinese cabbage, functional characteristic circRNAs response to calcium deficiency-induced tip-burn have not been reported. In this study, 730 were isolated from cabbage leaves, 23 22 differentially expressed different deficiency stages compared with control. Forty-six host genes identified, one circRNA was found act as miRNAs...
As one of the endocrine-disrupting chemicals (EDCs), dibutyl phthalate (DBP) has been extensively used in industry. DBP shown to cause damage Leydig cells, yet its underlying mechanism remains elusive. In this study, we show that induces ferroptosis mouse cells via upregulating expression Sp2, a transcription factor. Also, Sp2 is identified promote Vdac2 gene by binding promoter and subsequently involved DBP-induced cells. addition, proved induce inducing oxidative stress, while inhibition...
Evapotranspiration (ET) is a crucial component of the water cycle, and accurate regional ET quantification essential for agricultural management. Upscaling using flux towers measurements provides an effective means to bridge gap between local observations broader-scale assessments. However, current upscaling approaches are often conducted at watershed or global scales, where relatively coarse spatial resolutions limit their applicability field-scale To address these challenges, this study...
Tri-ortho-cresyl phosphate (TOCP) has been widely used as plasticizers, plastic softeners, and flame retardants in industry reported to have a deleterious effect on the male reproductive system animals besides delayed neurotoxicity. Our preliminary results found that TOCP could disrupt seminiferous epithelium testis inhibit spermatogenesis, but precise mechanism is yet be elucidated. This study shows inhibited viability of rat spermatogonial stem cells dose-dependent manner. not lead cell...
Chrysophanol prevented LPS/<sc>d</sc>-GalN-induced liver injury through the induction of antioxidant defence, suppression apoptosis and reduction inflammatory response<italic>via</italic>inhibition RIP140/NF-κB pathway.
Abstract As a widely used plasticizer in industry, di‐2‐ethylhexylphthalate (DEHP) can cause testicular toxicity, yet little is known about the potential mechanism. In this study, DEHP exposure dramatically inhibited cellviability and induced apoptosis of mouse GC‐1 spg cells. Furthermore, significantly increased levels autophagy proteins LC3‐II, Beclin1 Atg5, as well ratio ofLC3‐II/LC3‐I. Transmission electron microscopy (TEM) further confirmed that was also shown to induceoxidative stress;...
Zinc oxide nanoparticles (ZnO NPs) have been extensively used in various industries and reported to inhibit spermatogenesis, however, ZnO NPs-induced spermatogenesis failure is yet be fully elucidated. Herein, mouse-derived spermatogonia cell line GC-1 spg cells were treated with NPs for 24 h the presence or absence of radical scavenger N-acetyl-L-cysteine (NAC) autophagy inhibitor 3-methyladenine (3-MA), then viability was observed by MTT assay; apoptosis western blotting analysis...
Aim In this study, 5-fluorouracil (5-FU) is delivered to target colon without the interference of mononuclear phagocyte system (MPS).Methods Outer membrane vesicles (OMVs) were used as biological shield disguise mesoporous silica (MSN) and 5-FU. OMVs-MSN-5-FU prepared by high pressure co-extrusion, characterised on basis size, drug loading, transmission electron microscope, infra-red spectroscopy, differential scanning calorimetry, thermal gravity analysis, % in vitro release, MTT assay,...
Lysophosphatidylcholine (LPC), also known as lysolecithin, is one of the major components oxidized low-density lipoproteins (ox-LDL). In pathogenetic process diverse diseases, LPC acts a significant lipid mediator. However, no evidence shows that can affect female reproductive system. our study, we found inhibited cell viability primary mouse ovarian granulosa cells. Meanwhile, was shown to induce apoptosis, which accompanied by an increase in apoptosis-related protein levels, such cleaved...
In this study, a new type of β-1,3-d-glucan porous microcapsule (GPM)-enveloped and folate conjugated chitosan-functional liposome (FCL), FCL@GPM, was developed for the potential oral co-delivery chemotherapeutic drugs quantum dots (QDs) with facilitated drug absorption antitumor efficacy. dual-particulate system, multiple FCLs serve as cores effective loading, folate-mediated tumor-targeting, intracellular accumulation, pH-responsive controlled release agents, while GPM acts shell affording...