A5068120827- Plant Molecular Biology Research
- Research in Cotton Cultivation
- Ferroptosis and cancer prognosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Light effects on plants
- melanin and skin pigmentation
- Quinazolinone synthesis and applications
- Phytochemicals and Antioxidant Activities
- Histone Deacetylase Inhibitors Research
- Advanced Sensor and Energy Harvesting Materials
- Spinal Cord Injury Research
- Cancer-related molecular mechanisms research
- Antibiotic Resistance in Bacteria
- Ginseng Biological Effects and Applications
- Biochemical Analysis and Sensing Techniques
- Spine and Intervertebral Disc Pathology
- Glutathione Transferases and Polymorphisms
- Computational Drug Discovery Methods
- Liver Disease and Transplantation
- Plant Toxicity and Pharmacological Properties
- RNA modifications and cancer
- Spinal Hematomas and Complications
- Enzyme function and inhibition
- Bone Tissue Engineering Materials
- Genomics, phytochemicals, and oxidative stress
University of California, Los Angeles
2025
University of South China
2024
Shandong Academy of Agricultural Sciences
2021-2024
Shandong Normal University
2021-2024
China Agricultural University
2017-2024
Qinghai Provincial Peoples Hospital
2019-2023
The Affiliated Hospital to Changchun University of Chinese Medicine
2021-2023
Shanghai Jiao Tong University
2023
University College London
2018-2022
Beihua University
2019-2021
Large bone defects caused by tumors and traumas are difficult clinical problems. For its treatment, autogenous transplantation is the "gold standard". However, there some shortcomings of this such as limited supply extra trauma from removal. In recent years, orthopedic implants tissue engineering materials have developed rapidly, adding impetus to solution problem. At present, main include medical metal materials, polymer cement, ceramic artificial etc. Among which become research hotspot...
Abstract Stretchable electronics capable of conforming to nonplanar and dynamic human body surfaces are central for creating implantable on‐skin devices high‐fidelity monitoring diverse physiological signals. While various strategies have been developed produce stretchable devices, the signals collected from such often highly sensitive local strain, resulting in inevitable convolution with surface strain‐induced motion artifacts that difficult distinguish intrinsic Here all‐printed super...
Effect of imatinib on rats with spinal cord injury (SCI) was investigated through the nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. Forty-eight Sprague-Dawley were randomly divided into sham operation group (n=12), model (n=12) and inhibitor (n=12). The results immunohistochemistry showed that in comparison group, other three groups had overtly increased positive expression level Bax evidently reduced Bcl-2 (P<0.05). Compared those distinctly lower,...
Lower back pain is a common problem in middle-aged and elderly people, intervertebral disc degeneration (IVDD) often the main cause. The present study aimed to explore effects of dimethyl fumarate (DMF) on inflammation oxidative stress disc. C57/BL6 mice were used construct an IVDD model by tail suspension daily intraperitoneal injections 10 mg/kg DMF administered analyze IVDD. In addition, human nucleus pulposus (NP) cells cultured stimulated with recombinant IL-1β examine NP cells....
The clinical anti-inflammatory drug dexamethasone (DEX) can cause many side effects such as muscle atrophy for long-term use. Muscle induced by DEX may be caused decrease of glucose consumption. Panax ginseng C.A. Meyer was previously considered to an antiatrophic agent glucocorticoid- (GC-) treated therapies. As one the main components, it remains unclear whether total protein (GP) facilitates recovery from DEX.In this study, GP extracted and purified with Sephadex-G50. C2C12 myoblasts 2%...
Our previous investigation indicated that the preparation of Panax ginseng Meyer (P. ginseng) inhibited melanogenesis. It comprised salicylic acid (SA), protocatechuic (PA), p-coumaric (p-CA), vanillic (VA), and caffeic (CA). In this investigation, regulatory effects P. phenolic monomers on melanin production were assessed.In vitro in vivo impact assessed.SA, PA, p-CA VA tyrosinase (TYR) to reduce production, whereas CA had opposite effects. SA, significantly downregulated melanocortin 1...
Background: Long non-coding RNAs (lncRNAs) reportedly play important roles in biomarker and tumorigenesis of gastric cancer (GC). This study aimed to determine the potential application prognostic lncRNA signature identified role LINC01614 carcinogenesis GC. Material Methods: Data accessed from Cancer Genome Atlas database was used construct a signature. Joint effect analysis clinical parameters performed verify value Co-expression conducted for lncRNAs protein-coding genes. Moreover,...
HOOKLESS1 (HLS1) plays an indispensable role in apical hook development by promoting asymmetric auxin distribution the hook. However, precise mechanisms which HLS1 regulates differential gene expression inner and outer sides of to promote this remains unknown. The cotton were separated for sequencing search differently expressed auxin-related genes. Then, GhYUCCA8 GhGH3.17 genes, are highly side, respectively, as well GhHLS1, silenced SSA-VIGS method study their interaction function on...
Gastric cancer (GC) is among the most common forms of affecting digestive system. This study sought to identify hub genes regulating early GC (EGC) in order explore their potential for diagnosis and prognosis patients.We utilized a publically available dataset from Gene Expression Omnibus database (GSE55696). Differences between EGC LGIN with respect gene expression were compared using limma software. Identified differentially expressed (DEGs) subjected ontology (GO) pathway enrichment...
Inhibition of β-lactamases is a promising strategy to overcome antimicrobial resistance commonly used β-lactam antibiotics. Boronic acid derivatives have proven be effective inhibitors due their direct interaction with the catalytic site these enzymes. We synthesized series phenylboronic and evaluated structure-activity relationships as Klebsiella pneumoniae carbapenemase (KPC-2) inhibitors. identified potent KPC-2 2e & 6c (Ki = 0.032 μM 0.038 μM, respectively) that enhance activity...
<p id="C3">Realizing full and strong stand establishment of seedlings is the basis for achieving high yields bump harvests in cotton. However, cotton a dicotyledonous plant whose cotyledons are successfully all unearthed standing. Seedling emergence susceptible to environmental conditions seeding techniques. Therefore, it generally more difficult get than other major crops. The apical hook formation hypocotyl growth at seed germination stages play key roles seedling establishment. Here we...
Abstract Prolonged skin exposure to ultraviolet radiation can lead development of several acute and chronic diseases, with UVA considered a primary cause dermal photodamage. We prepared wild ginseng adventitious root extract (ARE) that could alleviate irradiation‐induced NIH‐3T3 cell viability decline. After employing series purification methods isolate main active components ARE, protein mixture (ARP) was identified then tested for protective effects against damage. The results showed ARP...
Malignant gliomas, characterized by pronounced heterogeneity, a complex microenvironment, and propensity for relapse drug resistaniguree, pose significant challenges in oncology. This study aimed to investigate the prognostic value of Ligand Receptor related genes (LRRGs) within glioma microenvironment. An intersection 71 ligand-related (LRGs) 2628 receptor-related (RRGs) yielded total 69 LRRGs. Utilizing least absolute shrinkage selection operator (LASSO) regression analysis, RiskScore...
Stretchable electronics capable of conforming to nonplanar and dynamic human body surfaces are central for creating implantable on-skin devices high-fidelity monitoring diverse physiological signals. While various strategies have been developed produce stretchable devices, the signals collected from such often highly sensitive local strain, resulting in inevitable convolution with surface strain-induced motion artifacts that difficult distinguish intrinsic Here we report all-printed super...
Abstract De novo molecular generation is a promising approach to drug discovery, building novel molecules from the scratch that can bind target proteins specifically. With increasing availability of machine learning algorithms and computational power, artificial intelligence (AI) has emerged as valuable tool for this purpose. Here, we have developed database 3D ligands collects six AI models de based on proteins, including 20 disease-associated targets. Our currently includes 1767 protein...