A5017696516- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Trace Elements in Health
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Cancer Research and Treatments
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- Heavy Metal Exposure and Toxicity
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Dialysis and Renal Disease Management
- Intraperitoneal and Appendiceal Malignancies
- Nanowire Synthesis and Applications
- Colorectal Cancer Treatments and Studies
First Affiliated Hospital of Guangdong Pharmaceutical University
2012-2024
Guangxi Medical University
2007-2024
Stomatology Hospital
2023-2024
Tumor Hospital of Guangxi Medical University
2012-2024
Third Affiliated Hospital of Southern Medical University
2013-2024
University of Virginia
2024
Guangdong Pharmaceutical University
2014-2023
Jinan University
2016-2022
Shanghai First People's Hospital
2019-2021
Shanghai Jiao Tong University
2021
In the central nervous system diseases, glioma is one of most common malignancies around world. Despite recent improvements in therapies for glioma, prognosis some high-risk remains poor. isoliquiritigenin (ISL) reported to have antioxidative and antitumor activities. However, potential mechanisms between ISL circle RNAs (circRNAs) tumorigenesis process not yet been reported. Here, we treated cells with ISL, circRNA expression levels were detected. Circ0030018 was found significantly...
Abstract Glioblastoma is a deadly cancer, with no effective therapies. Better understanding and identification of selective targets are urgently needed. We found that advillin (AVIL) overexpressed in all the glioblastomas we tested including glioblastoma stem/initiating cells, but hardly detectable non-neoplastic astrocytes, neural stem cells or normal brain. Glioma patients increased AVIL expression have worse prognosis. Silencing nearly eradicated culture, dramatically inhibited vivo...
Abstract Chimeric antigen receptor-based T-cell immunotherapy is a promising strategy for treatment of hematological malignant tumors; however, its efficacy towards solid cancer remains challenging. We therefore focused on developing nanobody-based CAR-T cells that treat the tumor. CD105 expression upregulated neoangiogenic endothelial and cells. has been developed as drug target. Here we show generation CD105-specific nanobody, an anti-human cells, by inserting sequences anti-CD105...
BACKGROUND Early screening methods for gastric cancer (GC) are lacking; therefore, the disease often progresses to an advanced stage when patients first start exhibit typical symptoms. Endoscopy and pathological biopsy remain primary diagnostic approaches, but they invasive not yet widely applicable early population screening. miRNA is a highly conserved type of RNA that exists stably in plasma. Dysfunction linked tumorigenesis progression, indicating individual miRNAs or combinations...
Here we explored the fusion of dendritic cells (DCs), potent antigen-presenting that initiate primary immune responses, with cancer-associated fibroblasts (CAFs), which are a stromal component needed for tumor progression, aim stimulating T to inhibit growth. Dendritic from bone marrow BALB/c mice were co-cultured CAFs H22 mouse hepatoma cells. found express fibroblast activation protein and α-smooth muscle actin by flow cytometry, Western blotting immunofluorescence. Polyethylene glycol was...
Cancer tissue-specific and nuclei-targeted drug delivery is ideal for the of chemotherapy. However, it has only been achieved in vitro studies mainly due to low efficiency vivo. In this study, we aimed establish an efficient dual-targeted system that targets liver cancer tissue as well nuclei cells vivo.We first synthesized TAT peptide (TATp)-mesoporous silica nanoparticle (MSN) complex (TATp-MSN) generated liposomes carried cancer-specific aptamer TLS11a (TLS11a-LB). We then...
Abstract Circular RNAs (circRNAs) are a kind of noncoding that have different biological functions. CircRNAs play very important parts in the progression cancers. Nevertheless, exact mechanism and function many circRNAs glioma not clear. In our study, circKIF4A was identified as remarkably upregulated circRNA expressed tissues cell lines. We performed loss-off gain-of-function experiments to inquire into glioma. discovered knockdown decreased proliferation invasion ability cells. Moreover,...
Cytotoxic T‑lymphocyte antigen‑4 (CTLA‑4) is a critical negative regulator of immune responses. CTLA‑4 rapidly upregulated following T‑cell activation, and then binds to B7 molecules with higher affinity than CD28. may abolish the initiation responses T cells by raising threshold signals required for full activation cells, it also terminate ongoing T-cell This regulatory role has led development monoclonal antibodies (mAbs) designed block activity enhancing against cancer. mAbs have several...
Introduction Transarterial chemoembolization (TACE) is inefficient at converting unresectable hepatocellular carcinoma (uHCC) to resectable. Treatment with immune checkpoint inhibitors (ICIs) an emerging strategy for uHCC. Combined therapy of TACE ICIs considered improve the therapeutic effect. Case presentation A 45-year-old man was diagnosed a bulky HCC under cirrhotic background without distant metastasis. Curative resection infeasible, and plus tislelizumab (an ICI targeting PD-1)...
Purpose Gastric cancer (GC) is associated with rapid disease progression and poor patient prognosis, highlighting the pressing need for new biomarkers to facilitate management. Exosomes are released by all cells ubiquitous in body fluids, thus giving them great potential as diagnostic therapeutic targets. MicroRNAs (miRNAs) can be transported exosomes, a common target regulation cancer. Methods Our screen of miRNAs Gene Expression Omnibus The Cancer Genome Atlas databases identified...
Background: Chimeric antigen receptor (CAR) T-cell therapy is practical in treating cancers of hematopoietic origin, but that solid tumors compromises efficacy for the loss recognized by CAR. However, dendritic cell (DC)/tumor fusion vaccines present a spectrum known or unknown tumor antigens to stimulate T expansion and enhanced response. Developing new strategy nanobody-based CAR-T (Nb-CAR-T) cells antitumor activity DC/tumor stimulation would provide guidance more effective therapies....
Abstract Background T cell engagers (TCEs) have been established as an emerging modality for hematologic malignancies, but solid tumors remain refractory. However, the upregulation of programmed death 1 (PD-1) is correlated with dysfunction that confer tumor-mediated immunosuppression. Developing a novel nanobody-based trispecific engager (Nb-TriTE) would be potential strategy to improve therapeutic efficacy. Methods Given nanobodies (Nbs), we first screened Nb targeting fibroblast...
Dendritic cell (DC)-based tumor vaccines are a promising immunotherapeutic method of cancer treatment. However, their therapeutic applications significantly limited by weak immunogenicity, costly culturing steps, and easily degradable properties. Thus, the anti-tumor activity for should be improved. In this study, novel lipid nanoparticle (M/CpG-ODN-H22-Lipo) was developed, which conjugated with synthetic CpG oligodeoxynucleotides (CpG-ODN) mannose then loaded H22 hepatoma lysate. Our data...
RNA processing mechanisms, such as alternative splicing and editing, have been recognized critical means to expand the transcriptome. Chimeric RNAs formed by intergenic provide another potential layer of diversification. By analyzing a large set RNA-Seq data validating results in over 1,200 blood samples, we identified
Objective The relationship between serum total cholesterol (TC) and triglyceride (TG) levels mortality in maintenance hemodialysis (MHD) patients remains inconsistent. We aimed to explore the individual combined association of TC TG with risk Chinese MHD patients.
Gastric cancer (GC) is one of the most common malignant tumors. More and more evidences support role microRNAs (miRNAs) in tumor progression. However, miRNAs human GC remains largely unknown.Based on published gastric expression profile data, combined with bioinformatics analysis, potential process were screened. The miR-199b-5p cells patients' plasma was detected by RT-PCR. effects vitro EdU proliferation assay, colony formation Transwell assay wound healing assay. Western blot used to...