A5023315687- Trigeminal Neuralgia and Treatments
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Head and Neck Surgical Oncology
- Cerebral Venous Sinus Thrombosis
- Meningioma and schwannoma management
- Cytokine Signaling Pathways and Interactions
- Lymphatic System and Diseases
- Prostate Cancer Treatment and Research
- Brain Metastases and Treatment
- Neurosurgical Procedures and Complications
- Aquaculture disease management and microbiota
- Bone and Joint Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Pharmacological Effects and Toxicity Studies
- interferon and immune responses
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Migraine and Headache Studies
- Esophageal Cancer Research and Treatment
- Management of metastatic bone disease
- Melanoma and MAPK Pathways
- Gastric Cancer Management and Outcomes
- Optical Coherence Tomography Applications
Zhejiang University
2014-2024
The University of Texas MD Anderson Cancer Center
1994-2023
Shanghai First Maternity and Infant Hospital
2022
82th Hospital of Pla
2020-2022
Chinese Medical Doctor Association
2021
Affiliated Hospital of Nantong University
2021
Nantong University
2010-2021
Guangxi Medical University
2021
Princess Margaret Cancer Centre
2020
Dalian Medical University
2017
Stereotactic biopsy is often performed for diagnostic purposes before treating patients whose imaging studies highly suggest glioma. Indications cited include diagnosis and/or the "inoperability" of tumor. This study questions routine use stereotactic in initial management gliomas. At The University Texas M. D. Anderson Cancer Center, we retrospectively reviewed a consecutive series 81 suggested glioma and who underwent followed by craniotomy/resection (within 60 days) between 1993 1998. All...
✓ Surgery and radiosurgery are effective treatment modalities for brain metastasis. To compare the results of these modalities, authors followed 31 patients treated by 62 surgery who were retrospectively matched. Patients matched according to following criteria: histological characteristics primary tumor, extent systemic disease, preoperative Karnofsky Performance Scale score, time metastasis, number metastases, patient age sex. For radiosurgery, median size lesion was 1.96 cm 3 (range...
Checkpoint immunotherapy has yielded meaningful responses across many cancers but shown modest efficacy in advanced prostate cancer. B7 homolog 3 protein (B7-H3/CD276) is an immune checkpoint molecule and emerged as a promising therapeutic target. However, much remains to be understood regarding B7-H3's role cancer progression, predictive biomarkers for B7-H3-targeted therapy, combinatorial strategies. Our multi-omics analyses identified B7-H3 one of the most abundant checkpoints tumors...
CD58 and CD2 have long been known as a pair of reciprocal adhesion molecules involved in the immune modulations CD8+ T NK-mediated cellular immunity humans several other mammals. However, functional roles CD4+ T-mediated adaptive humoral remain poorly defined. Moreover, current observations were mainly acquired from vitro assays, vivo investigation is greatly limited due to absence Cd58 homology murine models. In present study, we identified cd58 cd2 homologs model species zebrafish (Danio...
Abstract The BTLA−HVEM checkpoint axis plays extensive roles in immunomodulation and diseases, including cancer autoimmune disorders. However, the functions of this hepatitis remain limited. In study, we explored regulatory role Btla–Hvem a ConA-induced model zebrafish. Results showed that Btla Hvem were differentially expressed on intrahepatic Cd8+ T cells hepatocytes. Knockdown or significantly promoted hepatic inflammation. was highly healthy liver but downregulated inflamed liver, as...
Tyrosine kinase 2 (TYK2) mediates the interleukin-23 (IL-23), IL-12, and type I interferon (IFN)-driven signal responses that are critical in autoimmune diseases. Here, a series of novel derivatives with an N-(methyl-d3)pyridazine-3-carboxamide skeleton bind to TYK2 pseudokinase domain were designed, synthesized, evaluated. Among them, compound 30 demonstrated more excellent inhibitory potency against STAT3 phosphorylation than positive control deucravacitinib. In addition JAK isoform...
Object. Twenty-two patients who had solitary metastatic brain tumors with dural extension were treated surgically over a 3-year period. Their cases reviewed to characterize these lesions and compare the similar cohort in which there was no involvement. Methods. The median age of 58 years (range 11–68 years) male/female ratio 12:10. preoperative Karnofsky Performance Scale (KPS) score group 90 70–100). most common histological diagnoses seen included breast cancer, adenocarcinoma squamous...
Neurenteric cysts in the anterior craniocervical junction (CCJ) region can be found extremely rare cases. We report one case with neurenteric cyst that was excised by far-lateral transcondylar (FLT) approach. A 43-year-old man presented a history of recurrent episodes mild neck pain and dysesthesia his bilateral hands 2 years' duration rapid deterioration 3 weeks prior to admission. Magnetic resonance imaging (MRI) CCJ revealed well-defined intradural cystic lesion located ventral from...
Abstract Clinical studies have shown that subsets of patients with cancer achieve a significant benefit from Aurora kinase inhibitors, suggesting an urgent need to identify biomarkers for predicting drug response. Chromodomain helicase DNA binding protein 1 (CHD1) is involved in chromatin remodeling, repair, and transcriptional plasticity. Prior demonstrated CHD1 has distinct expression patterns cancers different molecular features, but its impact on responsiveness remains understudied....
Abstract Background Loss-of-function (LOF) mutations of JAK1, a member the JAK kinase family, were frequently observed in EC, indicating that JAK1 may act as tumor suppressor, at least EC. However, mechanism mediated regulation tumorigenesis remains poorly understood. Methods The genetic alterations EC using latest sequencing dataset deposited TCGA database. RNA-Seq and normal endometrial tissues from cohort was analyzed. expression investigated immunohistochemistry. levels genes cancer...
Introduction Recognition of flat and small neoplastic lesions by colonoscopy is still challenging. High-definition (HD) i-Scan a promising technique to maximize the sensitivity colonoscopy; however, whether can increase detection rate polyps unclear. The aim this study was prospectively compare HD with for in routine practice. Materials methods A total 449 patients who underwent first time were randomized 1 : ratio undergo HD+i-Scan or colonoscopy. Detected colorectal judged according type,...
Abstract: Nervus intermedius neuralgia (NIN) is a rare craniofacial with features of paroxysmal pain in the deep ear. Because sensory nerves overlap ear, diagnosis NIN often difficult and not definitive. Here, we present case 70-year-old woman who had deep-ear for more than 4 years was diagnosed trigeminal treated carbamazepine without relief another hospital. Magnetic resonance tomographic angiography revealed no neurovascular conflict nerve, whereas anterior inferior cerebellar artery...
To evaluate the efficacy of HbA1C in diagnosing diabetes subjects with primary hypertension.The results demonstrated that area under reciever operating characteristic ( ROC ) curve was 0.895,with corresponding sensitivity 85.4％,and specificity 82.2％,when optimal cutpoint 6.0％.Our study suggested ≥6.0％ can be used efficiently patients hypertension. Key words: Hypertension; ; Diabetes; Receiver curve; Diagnosis
Objective: To assess the curative effect of stage II femoral head necrosis treated by arthroscopy assisted lesion clearance, bone graft and titanium rod support. Methods: All patients (including 58 74 hips) were diagnosed as according to ARCO staging system during 2003-2013. In these patients, 15 hips IIA, 34 IIB 25 IIC. Located C-arm arthroscopy, minimally-invasive percutaneous pulp core decompression clearance within accurately performed, then, OAM composite autologous marrow was implanted...
Objective To assess the curative effect of arthroscopy assisted lesion accurate bone marrow core decompression, graft and titanium rod support on stage Ⅱ femoral head necrosis. Methods All patients (including 58 74 hips) were diagnosed as necrosis according to ARCO staging system from April 2003 December 2013. Among these patients, 11 (15 ⅡA, 25 (34 ⅡB 22 (25 ⅡC. Being located by C-arm arthroscopy, minimally-invasive percutaneous pulp decompression clearance within accurately...