A5100643584- Neurological disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Parkinson's Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Thermoregulation and physiological responses
- Infrared Thermography in Medicine
- Advanced Technologies in Various Fields
- Alcohol Consumption and Health Effects
- Estrogen and related hormone effects
- Biomedical and Engineering Education
- Neural dynamics and brain function
- Cancer Cells and Metastasis
- Pharmacogenetics and Drug Metabolism
- Flavonoids in Medical Research
- Olfactory and Sensory Function Studies
- Protein Kinase Regulation and GTPase Signaling
- Climate Change and Health Impacts
The University of Texas MD Anderson Cancer Center
2022-2025
Guangzhou Medical University
2016-2024
Tianjin University of Traditional Chinese Medicine
2024
Wuhan Third Hospital
2024
Zhongshan Hospital
2019-2023
Fudan University
2019-2023
Qilu University of Technology
2021-2023
Tsinghua University
2011-2022
University of Hong Kong
2020-2022
East China University of Science and Technology
2022
Checkpoint immunotherapy has yielded meaningful responses across many cancers but shown modest efficacy in advanced prostate cancer. B7 homolog 3 protein (B7-H3/CD276) is an immune checkpoint molecule and emerged as a promising therapeutic target. However, much remains to be understood regarding B7-H3's role cancer progression, predictive biomarkers for B7-H3-targeted therapy, combinatorial strategies. Our multi-omics analyses identified B7-H3 one of the most abundant checkpoints tumors...
Abstract Chromatin remodeling proteins contribute to DNA replication, transcription, repair, and recombination. The chromodomain helicase DNA-binding (CHD) family of remodelers plays crucial roles in embryonic development, neurogenesis, carcinogenesis. As the founding member, CHD1 is capable assembling nucleosomes, chromatin structure, regulating gene transcription. Dysregulation at genetic, epigenetic, post-translational levels common prostate cancer other malignancies. Through interacting...
The development of noninvasive approaches to precisely control neural activity in mammals is highly desirable. Here, we used the ion channel transient receptor potential ankyrin-repeat 1 (TRPA1) as a proof principle, demonstrating remote near-infrared (NIR) activation endogenous neuronal channels mice through an engineered nanoagonist. This achievement enables specific neurostimulation nongenetically modified mice. Initially, target-based screening identified flavins photopharmacological...
Alterations of electrophysiological activities, such as changed spike firing rates, reshaping the patterns, and aberrant frequency oscillations between subthalamic nucleus (STN) primary motor cortex (M1), are thought to contribute impairment in Parkinson's disease (PD). However, alterations characteristics STN M1 PD still unclear, especially under specific treadmill movement. To examine relationship activity STN-M1 pathway, extracellular trains local field potential (LFPs) were...
To compare the efficacy and safety of surgical resection plus radiofrequency ablation (SR-RFA) with transarterial chemoembolization (TACE) in patients multifocal hepatocellular carcinoma (HCC) beyond Milan criteria.From 2009 to 2015, a total 469 consecutive HCC criteria (≤5 nodules) treated SR-RFA (n=59) or TACE (n=410) were analyzed. Their overall survival (OS) rate was compared through propensity score matching (PSM) analysis at ratio 1:2, 141 identified (SR-RFA, n=47; TACE, n=94)....
Background: The associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) hepatocellular carcinoma (HCC) with fibrosis/cirrhosis is often associated limited growth of future remnant (FLR). We introduced a new procedure named transcatheter arterial embolization-salvaged ALPPS (TAE-salvaged ALPPS) which was shown to be especially suitable HCC patients cirrhosis or fibrosis who failed adequately respond conventional ALPPS. short-term efficacy safety the TAE-salvaged on...
Abstract Cytochrome P450 2C8 ( CYP 2C8) is one of the enzymes that primarily participate in producing metabolisms medications and P‐glycoprotein (P‐gp) has been regarded as important molecules chemotherapeutically induced multidrug resistance MDR ). In addition, pregnane X receptor PXR ) involved regulating both P‐gp. We aim to research effect on Taxol‐resistant non–small‐cell lung cancer NSCLC cells) via cells were treated with SR 12813, LY 335979, or si RNA . Cell counting kit CCK ‐8)...
Background: To explore biliary tract stone (BTS) as prognostic factors of intrahepatic cholangiocarcinoma (ICC). Methods: Clinical data 985 ICC patients were classified into no BTS group and group-subgrouped hepatolithiasis (HL) non-hepatolithiasis (NHL) group. Propensity score matching was utilized to mitigate baseline characteristics. Preoperative peripheral inflammation parameters (PPIP) further investigated. Immunostaining CD3, CD4, CD8, CD68, PD1 PD-L1 conducted. Results: Overall...
OBJECTIVE: Endothelial cells play a critical role in maintaining vascular function and kinetic homeostasis, but excessive accumulation of palmitic acid (PA) may lead to endoplasmic reticulum stress trigger endothelial cell dysfunction. Baicalin (BCL), natural plant extract, has received widespread attention for its biological activities anti-inflammation anti-oxidative stress. However, the mechanism BCL on PA-induced dysfunction is unclear. Therefore, aim this study was investigate whether...
Liver cirrhosis is closely related to the abnormal liver function and occurrence of cancer. Accurate non-invasive assessment great significance for preventing disease progression treatment decision-making. We aim develop validate a diagnostic model in patients with chronic hepatitis B (CHB).From July 2015 April 2017, seven-hundred fifty-four primary HBV-related cancer who underwent hepatectomy were reprospectively recruited. All examined 2D-SWE serologic testing preoperatively, which...
Actinomycetes play a vital role as one of the most important natural resources for both pharmaceutical and agricultural applications. The actinomycete strain SPRI-371, isolated from soil collected in Jiangsu province, China, was classified Streptomyces aureus based on its morphological, physiological, biochemical molecular biological characteristics. Its bacterial activity metabolites were identified aureonuclemycin (ANM), belonging to adenosine derivatives with formula C16H19N5O9 ANM A...
Middle cerebral artery (MCA) aneurysm is a serious medical condition mainly occurring in the proximal and bifurcation tracts. Evidence has indicated that endovascular treatment an effective surgical method for patients with MCA aneurysm. In present study, efficacy of low-profile visualized intraluminal support (LVIS) stent aneurysms was evaluated comparison using non-LVIS device. A total 92 who underwent LVIS or were included study. The clinical presentation, aneurysmal characteristics,...
Background: Astragaloside III has been used to treat different cancers; however their effect on breast cancer remains unknown. 
 Materials and methods: The present study examined the effects of from Astragalus membranaceus cell lines in vitro as well xenograft vivo. Results: results showed that could effectively reduce survival inhibit tumor growth potential mechanism is induction apoptosis signaling pathways. Conclusion: We believe provides a new therapeutic tool cancer.
Objective: To evaluate the efficacy and safety of surgical resection plus radiofrequency ablation (SR-RFA) for multifocal hepatocellular carcinoma (HCC) with 2 or 3 nodules compared (SR).Method: We retrospectively evaluated 824 consecutive HCC patients (SR, n = 754; SR-RFA, 70) from January 2009 to December 2015 performed propensity score matching (PSM) adjust patient imbalances at a ratio 1:4.Results: At baseline, in SR-RFA group had smaller tumour size worse liver function (including more...