Jian Chen

ORCID: 0000-0003-0370-7979
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About
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Research Areas
  • Hydraulic and Pneumatic Systems
  • Tribology and Lubrication Engineering
  • Phytochemicals and Antioxidant Activities
  • Atherosclerosis and Cardiovascular Diseases
  • Alcohol Consumption and Health Effects
  • Genomics and Phylogenetic Studies
  • Electromagnetic Fields and Biological Effects
  • Viral Infectious Diseases and Gene Expression in Insects
  • Signaling Pathways in Disease
  • Flavonoids in Medical Research
  • Infrared Thermography in Medicine
  • Neuroscience of respiration and sleep
  • Respiratory Support and Mechanisms
  • Peptidase Inhibition and Analysis
  • Natural product bioactivities and synthesis
  • Histone Deacetylase Inhibitors Research
  • Dupuytren's Contracture and Treatments
  • Bioactive Compounds and Antitumor Agents
  • Cardiac Fibrosis and Remodeling
  • Chronic Kidney Disease and Diabetes
  • Cavitation Phenomena in Pumps
  • Urological Disorders and Treatments
  • Nasolacrimal Duct Obstruction Treatments
  • Advanced Glycation End Products research
  • Acute Kidney Injury Research

Xiamen University of Technology
2025

Wuhan Third Hospital
2024

Deyang Stomatological Hospital
2024

Xiamen University
2024

Chengdu University of Traditional Chinese Medicine
2022

Shanghai Traditional Chinese Medicine Hospital
2021

Nantong Maternity and Child Health Hospital
2019

Nantong University
2019

Yuhuangding Hospital
2018

Jiangnan University
2013-2017

A new integrated dynamic model is developed by examining the motion equations and kinematics of slipper piston, coupled with lubrication properties oil film. This simultaneously addresses vibrations piston along characteristics film lubrication. To validate this model, a test apparatus constructed. It found that power loss simulated from pair comprises approximately 20–65% measured loss, while leakage flow rate generated constitutes around 30–50% rate. The vibration responses as well...

10.1177/13506501241308942 article EN Proceedings of the Institution of Mechanical Engineers Part J Journal of Engineering Tribology 2025-01-07

This study investigated the protective effects and antioxidant mechanisms of blueberry anthocyanin extract (BBAE) in vivo vitro using model acute CC14-induced liver injury mice. It was found that BBAE significantly inhibited ethanol-induced increases alanine aminotransferase, aspartate aminotransferase malondialdehyde a dose-dependent manner (P<0.05). The activities superoxide dismutase, catalase glycogen glutathione reductase were markedly increased group (P<0.01). also suppressed cellular...

10.1080/09540105.2011.634378 article EN Food and Agricultural Immunology 2012-02-07

Applying in silico simulations and vitro experiments, the amino acid proline was proved to have a profound influence on Streptomyces griseus trypsinogen, hydrogen bond between H(57) D(102) found be crucial for trypsin activity. By introducing an artificial propeptide, IVEF, titer of increased 6.71-fold.

10.1128/aem.00376-13 article EN Applied and Environmental Microbiology 2013-04-06

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10.2139/ssrn.4800317 preprint EN 2024-01-01

OBJECTIVE: Endothelial cells play a critical role in maintaining vascular function and kinetic homeostasis, but excessive accumulation of palmitic acid (PA) may lead to endoplasmic reticulum stress trigger endothelial cell dysfunction. Baicalin (BCL), natural plant extract, has received widespread attention for its biological activities anti-inflammation anti-oxidative stress. However, the mechanism BCL on PA-induced dysfunction is unclear. Therefore, aim this study was investigate whether...

10.3233/ch-242230 article EN Clinical Hemorheology and Microcirculation 2024-06-21

Abstract Free fatty acids (FFAs) have emerged as significant risk factors for atherosclerosis (AS). Prolonged exposure to FFAs induces vascular endothelial injury, including inflammatory responses and oxidative stress, which are central events in AS. Chromofungin (CHR), a peptide derived from chromogranin A (CGA), has been implicated various biological functions. However, its physiological roles biology involvement the pathological development of AS not previously reported. In present study,...

10.1002/bab.2676 article EN Biotechnology and Applied Biochemistry 2024-10-02

Lipoid proteinosis (LP) is a rare form of dermatosis with autosomal recessive inheritance. The present study hypothesized that an extracellular matrix protein 1 (ECM1) gene mutation forms the pathological basis LP. association between ECM1 and LP; however, requires further investigation was thus investigated in study. Injury skin tissue samples from patients LP were collected, along venous blood for genomic DNA extraction. Immunohistochemical staining performed. Polymerase chain reaction...

10.3892/mmr.2018.8928 article EN Molecular Medicine Reports 2018-04-24

A new integrated dynamic model is developed by examining the motion equations and kinematics of slipper piston, coupled with lubrication properties oil film. This simultaneously addresses vibrations piston along characteristics film lubrication. To validate this model, a test apparatus constructed. The vibration responses as well characteristics, are analyzed under various load pressures speeds. central thickness exhibit comparable magnitudes. at harmonic frequencies decreases increasing...

10.2139/ssrn.4820202 preprint EN 2024-01-01
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