A5063144492- Optical Network Technologies
- Advanced Photonic Communication Systems
- Aquaculture disease management and microbiota
- T-cell and B-cell Immunology
- Photonic and Optical Devices
- Immune Cell Function and Interaction
- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- interferon and immune responses
- Carbon and Quantum Dots Applications
- Advanced Fiber Laser Technologies
- MicroRNA in disease regulation
- Zebrafish Biomedical Research Applications
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Viral Infections and Vectors
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Plant biochemistry and biosynthesis
- Inflammasome and immune disorders
- Cancer Immunotherapy and Biomarkers
- Mercury impact and mitigation studies
- Heat shock proteins research
Zhejiang University
2014-2025
Liaocheng University
2024-2025
National University of Defense Technology
2022-2025
Soochow University
2024
Southeast University
2023
Jilin University
2017-2022
Tianjin University of Commerce
2022
Shandong University
2015-2022
Guangdong Medical College
2020-2021
Anhui Agricultural University
2020
Ovarian granulosa cells (GCs) proliferate and differentiate along with follicular growth, this is indispensable for oocyte development female fertility. Although the role of macroautophagy/autophagy in ovarian function has been reported, its contribution to regulation GC characteristics remains elusive. The siRNA-mediated knockdown two key autophagy-related genes ATG5 BECN1 autophagy inhibitor chloroquine were used interfere GCs. Inhibition both genetically pharmacologically resulted...
The long-held paradigm that B cells cannot uptake nonspecific particulate Ags for the initiation of primary adaptive immunity has been challenged by recent discovery teleost have potent phagocytic and microbicidal abilities. This provides preliminary clues primitive might act as initiating APCs in priming immunity. In this study, zebrafish clearly showed a Ag-presenting ability to both soluble bacterial particles prime naive CD4(+) T cell activation. finding demonstrates innate-like nature...
We propose and experimentally demonstrate a photonic multichannel terahertz (THz) wireless system with up to four optical subcarriers total capacity as high 100 Gb/s by employing an externally injected gain-switched laser comb source. Highly coherent multiple carriers different spacing are produced using the gain switching technique. Single- Terahertz signals generated heterodyne mixing of modulated single or one unmodulated tone spaced about 200 GHz. The frequency stability phase noise...
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is one of the best-characterized inflammasomes in humans and other mammals. However, knowledge about NLRP3 nonmammalian species remains limited. Here, we report molecular functional identification an homolog (DrNLRP3) a zebrafish (Danio rerio) model. We found that DrNLRP3's overall structural architecture was shared with mammalian NLRP3s. It initiates classical assembly for inflammatory caspase (DrCaspase-A/-B) activation...
The precise placement of thioester bonds into sequence-controlled polymers remains a grand challenge. Here, we demonstrate the versatile synthesis from step polymerization cyclic thioanhydrides (A), diacrylates (B), and diols/diamines (C). In addition to easily accessible diverse monomers, method is metal-free/catalyst-free, atom-economical, wide in monomer scope, yielding 107 with >90% yields weight-average molecular weights up 175.4 kDa. obtained contain ABAC-type repeating units precisely...
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is one of the best-characterized inflammasomes in humans and other mammals. However, knowledge about NLRP3 nonmammalian species remains limited. Here, we report molecular functional identification an homolog (DrNLRP3) a zebrafish (Danio rerio) model. We found that DrNLRP3's overall structural architecture was shared with mammalian NLRP3s. It initiates classical assembly for inflammatory caspase (DrCaspase-A/-B) activation...
NLRP1 inflammasome is one of the best-characterized inflammasomes in humans and other mammals. However, existence this nonmammalian species remains poorly understood. In study, we report molecular functional identification an homolog, Danio rerio (DrNLRP1) from a zebrafish (D. rerio) model. This DrNLRP1 possesses similar structural architecture to mammalian NLRP1s. It can trigger formation classical for activation inflammatory caspases Caspase [DrCaspase]-A DrCaspase-B) maturation D. IL-1β...
Endothelial cell senescence is one of the most important causes vascular dysfunction and atherosclerosis. Circular RNAs (circRNAs) are endogenous RNA molecules with covalently closed-loop structures, which have been reported to be abnormally expressed in many human diseases. However, potential role circRNAs endothelial atherosclerosis remains largely unknown. Here, we compared expression patterns young senescent cells sequencing. Among differentially circRNAs, circGNAQ, a circRNA enriched...
Abstract Mesenchymal stem cell (MSC) therapy has become a promising treatment for liver fibrosis due to its predominant immunomodulatory performance in hepatic stellate inhibition and resolution. However, the cellular molecular mechanisms underlying these processes remain limited. In present study, we provide insights into functional role of bone marrow-derived MSCs (BM-MSCs) alleviating by targeting intrahepatic Ly6C hi lo macrophage subsets mouse model. Upon chronic injury, subset was...
Abstract Cancer cells harbor cell-intrinsic programs capable of sculpting immunogenic landscapes, yet molecular brakes that enforce immune evasion remain poorly defined. Here, we identify C9ORF50, a previously uncharacterized intrinsically disordered protein, as liquid-liquid phase separation-driven regulator RNA processing and actionable immunotherapy target. Genetic ablation C9ORF50 induces selective intron retention in spliceosome component transcripts, leading to cytoplasmic accumulation...
In this paper, we propose a multi-carrier THz wireless communication system using an injection-locked gain-switched laser as optical comb source. The phase noise of the 192 GHz signal resulting from beating two lines is theoretically analyzed and experimentally examined. Moreover, three channel, 10 Gbaud QPSK generated, transmission over 40 km standard single mode fiber (SSMF) demonstrated.
CD58 and CD2 have long been known as a pair of reciprocal adhesion molecules involved in the immune modulations CD8+ T NK-mediated cellular immunity humans several other mammals. However, functional roles CD4+ T-mediated adaptive humoral remain poorly defined. Moreover, current observations were mainly acquired from vitro assays, vivo investigation is greatly limited due to absence Cd58 homology murine models. In present study, we identified cd58 cd2 homologs model species zebrafish (Danio...
Peroxiredoxin (Prx) was previously known as a Cys-dependent thioredoxin. However, we unexpectedly observed that Prx1 from the green spotted puffer fish Tetraodon nigroviridis (TnPrx1) able to reduce H2O2 in manner independent of Cys peroxidation and reductants. This study aimed validate novel function for Prx1, delineate biochemical features explore its antioxidant role cells. We have confirmed humans truly possesses catalase (CAT)-like activity is residues reductants, but dependent on iron....
Cyclic GMP-AMP synthase (cGAS) is one of the most-characterized cytoplasmic DNA sensors in humans and other mammals. However, knowledge about cGAS homologs nonmammalian species remains limited. In this study, we report molecular functional identification two homologs, namely, DrcGASa DrcGASb, from a zebrafish (Danio rerio) model. DrcGASb share same overall conservative structural architectures domains/residues to mammalian cGASs. Both synthesized 2′3′-cGAMP isomer but not 3′3′-cGAMP via...