A5060552645- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Folate and B Vitamins Research
- Advanced Glycation End Products research
- Trace Elements in Health
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Cardiovascular Health and Disease Prevention
- Neonatal Health and Biochemistry
- Parathyroid Disorders and Treatments
- Crop Yield and Soil Fertility
- Iron Metabolism and Disorders
- Renal Diseases and Glomerulopathies
- Gout, Hyperuricemia, Uric Acid
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 Clinical Research Studies
- Alcohol Consumption and Health Effects
- SARS-CoV-2 and COVID-19 Research
- Glycosylation and Glycoproteins Research
- Pancreatic function and diabetes
- Heart Failure Treatment and Management
- Heavy Metal Exposure and Toxicity
- Renin-Angiotensin System Studies
- Neonatal and Maternal Infections
Southern Medical University
2016-2025
Nanfang Hospital
2016-2025
National Clinical Research
2016-2025
Shanxi Agricultural University
2024-2025
Xi'an Chest Hospital
2025
Beijing Chao-Yang Hospital
2025
Capital Medical University
2025
Dongguan People’s Hospital
2025
National Clinical Research Center for Digestive Diseases
2019-2024
Guangdong Provincial People's Hospital
2005-2024
Importance The role of mycophenolate mofetil (MMF) in management immunoglobulin A nephropathy (IgAN) remains highly controversial. Objective To evaluate the efficacy and safety MMF patients with IgAN at high risk kidney function loss. Design, Setting, Participants This randomized clinical trial open-label, blinded end-point design was conducted among adults IgAN, proteinuria greater than 1.0 g/d, estimated glomerular filtration rate (eGFR) 30 less 60 mL/min/1.73m 2 or persistent hypertension...
Epidemiological evidence has indicated that vitamin D deficiency increased the risk of insulin resistance in metabolic syndrome. The present study was conducted to test hypothesis 1,25-dihydroxyvitamin may improve free fatty-acid (FFA)-induced muscle cells.The cell model established by treatment FFA differentiated C2C12 cells. Glucose uptake myotubes analysed 3H-labelled 2-deoxyglucose assay. diameter measured under condition glutaraldehyde-induced autofluorescense. Tyrosine phosphorylated...
<h3>Importance</h3> The efficacy of folic acid therapy on renal outcomes has not been previously investigated in populations without fortification. <h3>Objective</h3> To test whether treatment with enalapril and is more effective slowing function decline than alone across a spectrum at baseline from normal to moderate chronic kidney disease (CKD) among Chinese adults hypertension. <h3>Design, Setting, Participants</h3> In this substudy eligible China Stroke Primary Prevention Trial (CSPPT),...
Tubular epithelium constitutes the majority of renal parenchyma and is primary target various kidney injuries. However, how injured tubules drive interstitial fibroblast activation proliferation remains poorly understood. Here, we investigated role sonic hedgehog (Shh), a secreted extracellular signaling protein, in proliferation. Shh was induced tubular epithelia animal models CKD by ischemia/reperfusion injury (IRI), adriamycin, or mass ablation, biopsy specimens from patients with...
Abstract Chronic kidney disease (CKD) affects 10–15% of the population worldwide, results in high morbidity and mortality, requires costly treatment renal replacement therapy. Glomerulosclerosis, tubulointerstitial fibrosis, persistent intestinal flora disturbance are common CKD. Short-chain fatty acids (SCFAs), produced by microbiota, have been previously reported to ameliorate injury; however, specific concentrations types that required improve function remain unknown. The present study...
TGF- β 1, via Smad-dependent or Smad-independent signaling, has a central role in the pathogenesis of renal fibrosis. This pathway been recognized as potential target for antifibrotic therapy. Here, we identified GQ5, small molecular phenolic compound isolated from dried resin Toxicodendron vernicifluum , potent and selective inhibitor 1–induced Smad3 phosphorylation. In 1–stimulated tubular epithelial cells interstitial fibroblast cells, GQ5 inhibited interaction with type I receptor (T RI)...
We evaluated the interaction of serum folate and vitamin B12 with methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on risk first ischemic stroke efficacy folic acid treatment in prevention stroke.A total 20,702 hypertensive adults were randomized to a double-blind daily enalapril 10 mg 0.8 or alone. Participants followed up every 3 months.Median values concentrations at baseline 8.1 ng/mL 280.2 pmol/L, respectively. Over median 4.5 years, among those not receiving acid,...
Background and objectives The relationship of depressive symptoms with kidney function remains poorly investigated. We aimed to evaluate the prospective association between rapid decline in Chinese adults normal function. Design, setting, participants, & measurements A total 4763 participants eGFR≥60 ml/min per 1.73 m 2 at baseline were enrolled from China Health Retirement Longitudinal Study. Baseline determined using a ten-item Center for Epidemiologic Studies Depression scale cutoff...
Mesangial deposition of extracellular matrix (ECM) is a hallmark several glomerular diseases including diabetic nephropathy. Accumulation advanced oxidation protein products (AOPPs) has been found in diabetes and chronic kidney disease linked to mesangial ECM progressive glomerulosclerosis these disorders. Although emerging evidence implicates AOPPs as the renal pathogenic factors, underlying mechanisms have not investigated. Here, using cultured rat cells (MCs) model, we identify important...
Abstract Background Acute worsening of renal function, an independent risk factor for adverse outcomes in acute decompensated heart failure (ADHF), occurs as a consequence new onset kidney injury (AKI) or deterioration pre-existed chronic disease (CKD) (acute-on-chronic injury, ACKI). However, the possible difference prognostic implication between AKI and ACKI has not been well established. Methods We studied all consecutive patients hospitalized with ADHF from 2003 through 2010 Nanfang...
We aimed to examine whether baseline homocysteine (Hcy) concentrations affect antihypertensive responses enalapril treatment among previously untreated hypertensive patients (n=10 783) in the CSPPT (China Stroke Primary Prevention Trial).After a 3-week run-in with daily dose of 10 mg enalapril, eligible were randomly assigned double-blind tablet either (10 mg) and folic acid (0.8 or alone for median 4.5 years. After period alone, systolic blood pressure-lowering effect was significantly...
Intracardiac leiomyomatosis (ICL) is an uncommon condition characterized by the proliferation of intravascular tissue within veins, leading to development tumor emboli. This can pose a significant threat life when invades cardiac structures. The diagnostic process for this complex and presents considerable challenges. We report case 38-year-old female patient whose pulmonary artery computed tomography (CT) revealed low density structure in branches artery. Echocardiography mobile right heart...
Introduction. The pharmacokinetic data on dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, is limited in patients with severe renal impairment. We aimed to evaluate the properties and safety of dapagliflozin chronic kidney disease (CKD) stage 4. Methods. This was single center, open label, trial involving multiple doses. Patients an estimated glomerular filtration rate (eGFR) 15-<30 mL/min/1.73m2 were enrolled. single-dose group received 10mg oral once daily, while...
Ceftazidime avibactam (CAZ-AVI) is recommended for treating severe infections caused by multidrug-resistant gram-negative bacteria (MDR-GNB). However, there are few real-world studies on the use of CAZ-AVI to treat lower respiratory tract (LRTIs) MDR-GNBs in intensive care units (ICUs). This study aimed evaluate clinical characteristics patients with LRTIs MDR-GNB who were treated ICU, and investigate independent risk factors mortality. single-center retrospective included ICU a tertiary...
Abstract Triceps skinfold thickness (TSF) is a surrogate marker of subcutaneous fat. Evidence limited about the association sex-specific TSF with risk all-cause mortality among maintenance hemodialysis (MHD) patients. We aimed to investigate longitudinal relationship MHD A multicenter prospective cohort study was performed in 1034 patients undergoing MHD. The primary outcome mortality. Multivariable Cox proportional hazards models were used evaluate mean (standard deviation) age population...
Abstract Background Current evidence on the relationship between dietary carbohydrate intake (DCI) and mortality risk among patients undergoing maintenance hemodialysis (MHD) is limited. Moreover, joint impact of DCI energy (DEI) remains unclear. Therefore, we aimed to investigate both individual combined associations DEI with all-cause cardiovascular disease (CVD) mortality. Methods This study included 1,044 MHD from eight outpatient dialysis centers across China. The DCI, expressed as a...
This study aimed to investigate the effects of different planting density and row spacing configurations on maize corn yield, leaf photosynthetic parameters, senescence characteristics; reveal purpose physiological mechanism interaction regulatsving yield; clarify optimal combinations for optimizing population structure, delaying senescence, improving light energy utilization efficiency. In doing so, this provides a theoretical basis technical guidance increasing sustainable development...
Whether the burden of advanced oxidation protein products (AOPP) accumulation, a marker oxidative stress, is affected by dialysis modality remains unclear. We compared serum levels AOPP in patients on haemodialysis (HD) and continuous ambulatory peritoneal (CAPD) tested hypothesis that an accumulation was independent risk factor for cardiovascular disease.This cross-section study. A total 2095 (1539 HD, 556 CAPD) were recruited from nine largest centres China. Persons medical disease...