A5101585218- Inflammasome and immune disorders
- interferon and immune responses
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Adenosine and Purinergic Signaling
- Immune Response and Inflammation
- Kawasaki Disease and Coronary Complications
- Heme Oxygenase-1 and Carbon Monoxide
- Receptor Mechanisms and Signaling
- COVID-19 Clinical Research Studies
- UAV Applications and Optimization
- Autophagy in Disease and Therapy
- Guidance and Control Systems
- Retinal Development and Disorders
- COVID-19 Impact on Reproduction
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Ginger and Zingiberaceae research
- Photoreceptor and optogenetics research
- Phytochemicals and Medicinal Plants
- Mobile Agent-Based Network Management
- Fluid Dynamics and Heat Transfer
- Insect symbiosis and bacterial influences
- IL-33, ST2, and ILC Pathways
- Protein Kinase Regulation and GTPase Signaling
First Affiliated Hospital of Zhengzhou University
2024
Jianghan University
2024
Shenzhen Luohu People's Hospital
2024
Shenzhen University
2024
Wenzhou Medical University
2024
Sichuan Agricultural University
2023
Second Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
Third Affiliated Hospital of Sun Yat-sen University
2022
Sun Yat-sen University
2022
Abstract Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to also COVID-19 severity. Here, we show a distinct mechanism by which N protein promotes NLRP3 inflammasome activation induce hyperinflammation. facilitates maturation proinflammatory cytokines and induces cultured cells mice. Mechanistically, interacts directly protein, the binding ASC, assembly. More importantly, aggravates lung...
Zika virus (ZIKV) infection is a public health emergency and host innate immunity essential for the control of infection. The NLRP3 inflammasome plays key role in immune responses by activating caspase-1 to facilitate interleukin-1β (IL-1β) secretion. Here we report that ZIKV stimulates IL-1β secretion infected patients, human PBMCs macrophages, mice, mice BMDCs. knockdown cells knockout inhibit ZIKV-mediated secretion, indicating an ZIKV-induced activation. Moreover, NS5 protein required...
One of the fundamental reactions innate immune responses to pathogen infection is release pro-inflammatory cytokines, including IL-1β, processed by NLRP3 inflammasome. The stimulator interferon genes (STING) has essential roles in response against infections. Here we reveal a distinct mechanism which STING regulates inflammasome activation, IL-1β secretion, and inflammatory human cell lines, mice primary cells, mice. Interestingly, upon HSV-1 cytosolic DNA stimulation, binds promotes...
SARS-CoV-2 is highly pathogenic in humans and poses a great threat to public health worldwide. Clinical data shows disturbed type I interferon (IFN) response during the virus infection. In this study, we discovered that nucleocapsid (N) protein of plays an important role inhibition beta (IFN-β) production. N repressed IFN-β production induced by poly(I:C) or upon Sendai (SeV) We noted also suppressed production, several signaling molecules downstream retinoic acid-inducible gene (RIG-I)...
Polysaccharide extracted from okra (Abelmoschus esculentus (L.) Moench), a traditional functional food, is biologically active substance reported to possess hypoglycemic and anti-oxidative qualities. However, it unknown which polysaccharides play role have the potential mechanism. This present study assess possible impacts of novel polysaccharide isolated (OP) on mice fed with high-fat diet (HFD) combined an intraperitoneal injection (i.p.) 100 mg/kg streptozotocin (STZ) twice, induce type 2...
Activation of NLRP3 inflammasome is important for effective host defense against invading pathogen. Together with apoptosis-associated speck-like protein containing CARD domain (ASC), induces the cleavage caspase-1 to facilitate maturation interleukin-1beta (IL-1β), an pro-inflammatory cytokine. IL-1β subsequently plays critical roles in inflammatory responses by activating immune cells and inducing many secondary cytokines. Although role response well defined, mechanism underlying its...
Zika virus (ZIKV) has emerged as a global health threat due to its unexpected causal link devastating neurological disorders such fetal microcephaly; however, date, no approved vaccine or specific treatment is available for ZIKV infection. Here we develop biomimetic nanodecoy (ND) that can trap ZIKV, divert away from intended targets, and inhibit The ND, which composed of gelatin nanoparticle core camouflaged by mosquito medium host cell membranes, effectively adsorbs inhibits replication in...
Dengue virus (DENV) infection causes serious clinical symptoms, including dengue hemorrhagic fever (DHF) and shock syndrome (DSS). Vascular permeability change is the main feature of diseases, abnormal expression proinflammatory cytokines important cause vascular change. However, mechanism underlying induced by DENV has not been fully elucidated. Here, we reveal a distinct which promotes NLRP3 inflammasome activation interleukin-1 beta (IL-1β) release to induce endothelial leakage in mice. M...
Abstract Background Extracellular adenosine triphosphate (ATP), a key danger-associated molecular pattern (DAMP) molecule, is released to the extracellular medium during inflammation by injured parenchymal cells, dying leukocytes, and activated platelets. ATP directly activates plasma membrane channel P2X7 receptor (P2X7R), leading an intracellular influx of K + , trigger inducing NLRP3 inflammasome activation. However, mechanism underlying P2X7R-mediated activation poorly understood,...
Protein kinase C (PKC) links various extracellular signals to intracellular responses and is activated by diverse factors including diacylglycerol, Ca2+, arachidonic acid. In this study, using a fully functional green fluorescent protein conjugated PKCbetaII (GFP-PKCbetaII), we demonstrate novel approach study the dynamic redistribution of PKC in live cells response G protein-coupled receptor activation. Agonist-induced translocation was rapid, transient, selectively mediated activation...
Dengue virus (DENV) infection causes several diseases ranging from dengue fever to life-threatening hemorrhagic and shock syndrome characterized by endothelial dysfunction, vascular leakage, shock. Here, we identify a potential mechanism which DENV induces tissue injury leakage promoting the activation of interleukin (IL)-1β. facilitates IL-1β secretion in infected patients, mice, human peripheral blood mononuclear cells (PBMCs), mouse bone marrow-derived macrophages (BMDMs),...
During host-virus co-evolution, cells develop innate immune systems to inhibit virus invasion, while viruses employ strategies suppress responses and maintain infection. Here, we reveal that Zika (ZIKV), a re-emerging arbovirus causing public concerns devastating complications, restricts host through distinct mechanism. ZIKV nonstructural protein 5 (NS5) interacts with the retinoic acid-inducible gene I (RIG-I), an essential signaling molecule for defending pathogen infections. NS5...
The NACHT, leucine-rich repeat, and pyrin domains-containing protein 3 (collectively known as NLRP3) inflammasome activation plays a critical role in innate immune pathogenic microorganism infections. However, excessive of NLRP3 will lead to cellular inflammation tissue damage, naturally it must be precisely controlled the host. Here, we discovered that solute carrier family 25 member (SLC25A3), mitochondrial phosphate protein, an important negatively regulating activation. We found SLC25A3...
Suan-Zao-Ren decoction is a classic traditional Chinese medicinal prescription, which has been used in the clinical treatment of insomnia and anxiety for thousands years.
ABSTRACT Background Sepsis‐associated encephalopathy (SAE) is a serious neurologic complication in septic patients with poor prognoses. There increasing evidence that stimulator of interferon genes (STING) plays crucial role neuroinflammation and cognitive impairment. However, whether sepsis associated STING changes contributes to impairment unknown. Methods Male adult mice received lipopolysaccharide (LPS) injection (a single dose 4 mg/kg; i.p. injection) 30 min later, they were injected...
Abstract Heterotrimeric G proteins play central roles in many signaling pathways, including the phototransduction cascade animals. However, degree of involvement protein subunit Gαq is not clear since animals with previously reported strong loss-of-function mutations remain responsive to light stimuli. We recovered a new allele Drosophila that abolishes response conventional electroretinogram assay, and reduces sensitivity whole-cell recordings dissociated cells by at least five orders...
A long noncoding RNA (lncRNA) is longer than 200 bp. It regulates various biological processes mainly by interacting with DNA, RNA, or protein in multiple kinds of processes. Adenosine monophosphate (AMP)-activated kinase (AMPK) activated during nutrient starvation, especially glucose starvation and oxygen deficiency (hypoxia), exposure to toxins that inhibit mitochondrial respiratory chain complex function. AMPK an energy switch organisms controls cell growth cellular processes, including...
The purpose of this case report and literature review is to show that familial episodic pain syndrome (FEPS) a non-inflammatory genetically inherited syndrome. A 3-year-old boy presented at our hospital with in both his forearms lower limbs below the knees for more than 3 years. There were no abnormalities blood tests, smears, liver kidney function trace elements cellular immunity test, humoral autoantibody C-reactive protein (CRP) erythrocyte sedimentation rate (ESR) tumor-related bone...
Abstract Excessive inflammatory responses induced upon SARS-CoV-2 infection interlocks with severe symptoms and acute lung injury in patients Severe Coronavirus Disease 2019 (COVID-19). Revealing the mechanism underlying control of SARS-CoV-2-triggered immune-inflammatory would help us to understand pathological process guide clinical treatment. However, effect NLRP3 inflammasome on regulating SARS-CoV-2-induced has not been reported. Here, we revealed a distinct by which nucleocapsid (N)...