A5001448252- IL-33, ST2, and ILC Pathways
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Plant Virus Research Studies
- Toxoplasma gondii Research Studies
- Dermatology and Skin Diseases
- Herpesvirus Infections and Treatments
- Psoriasis: Treatment and Pathogenesis
- Viral Infections and Vectors
- Heme Oxygenase-1 and Carbon Monoxide
- Viral Infections and Immunology Research
- Digestive system and related health
- Advancements in Transdermal Drug Delivery
- Asthma and respiratory diseases
- Machine Learning and ELM
- RNA Interference and Gene Delivery
- Viral Infections and Outbreaks Research
- Kawasaki Disease and Coronary Complications
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Phagocytosis and Immune Regulation
- interferon and immune responses
- Inflammatory Bowel Disease
- MicroRNA in disease regulation
Guangzhou Medical University
2019-2025
Jinan University
2018-2025
Qingzhou City People's Hospital
2024
First Affiliated Hospital of Jinan University
2019
Third Affiliated Hospital of Guangzhou Medical University
2019
Guizhou University
2018
Abstract Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to also COVID-19 severity. Here, we show a distinct mechanism by which N protein promotes NLRP3 inflammasome activation induce hyperinflammation. facilitates maturation proinflammatory cytokines and induces cultured cells mice. Mechanistically, interacts directly protein, the binding ASC, assembly. More importantly, aggravates lung...
Abstract Viral infection in respiratory tract usually leads to cell death, impairing function cause severe disease. However, the diversity of clinical manifestations SARS-CoV-2 increases complexity and difficulty viral prevention, especially high-frequency asymptomatic risk virus transmission. Studying how affects apoptotic pathway may help understand pathological process its infection. Here, we uncovered imployed a distinct anti-apoptotic mechanism via N protein. We found virus-like...
Abstract Global coronavirus disease 2019 (COVID‐19) pandemics highlight the need of developing vaccines with universal and durable protection against emerging SARS‐CoV‐2 variants. Here we developed an extended‐release vaccine delivery system (GP‐diABZI‐RBD), consisting original WA1 strain receptor‐binding domain (RBD) as antigen diABZI stimulator interferon genes (STING) agonist in conjunction yeast β‐glucan particles (GP‐diABZI) platform. GP‐diABZI‐RBD could activate STING pathway inhibit...
The imbalance of T lymphocyte subsets substantially conduces to disturbed intestinal immune system and succeeding colonic tissue damage in inflammatory bowel diseases. It is considered that regulation phytochemicals on cytokine production potentially provides a broad prospect for the exploitation immunomodulatory agents. Here, we reported oral administration feruloylated oligosaccharides (FOs) effectively alleviated mice colitis disease induced by dextran sulfate sodium (DSS). FOs decreased...
Exosomal microRNAs (miRNAs) serve as dependable and noninvasive biomarkers for early cancer diagnosis. However, the accurate feasible detection of exosomal miRNAs is often hindered by their low abundance requirement specialized equipment miRNA detection. In this study, we present a novel approach, termed primer exchange reaction-based fluorescence emission with cascade RNA aptamers transcription (PERFECT) highly sensitive miRNA. The design method involves selective interaction DNA probe...
Zika virus (ZIKV) is a member of the Flaviviridae family and causes congenital microcephaly Guillain–Barré syndrome. Currently, there lack approved vaccines or therapies against ZIKV infection. In this study, we profile vRNA‒host protein interactomes at stem‒loop B (SLB) reveal that interleukin enhancer binding factor 3 (ILF3) DEAH-box helicase 9 (DHX9) form positive regulators antiviral RNA inference in undifferentiated human neuroblastoma cells induced pluripotent stem cell-derived neural...
Amino acid (aa) metabolism is closely correlated with the pathogenesis of psoriasis; however, details on aa transportation during this process are barely known. Here, we find that SLC38A5, a sodium-dependent neutral transporter counter-transports protons, markedly upregulated in psoriatic skin both human patients and mouse models. SLC38A5 deficiency significantly ameliorates psoriasis, indicating pathogenic role SLC38A5. Surprisingly, almost exclusively expressed dendritic cells (DCs) when...
Abstract Background Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by the presence of numerous autoantibodies. The interaction infectious agents (viruses, bacteria and parasites) genetically susceptible host may be key mechanism for SLE. Toxoplasma gondii widespread intracellular parasite that has been implicated in pathogenesis diseases. However, relationship between T. infection increased risk SLE Chinese populations remains unclear. Methods...
Allergic rhinitis (AR) is the most common cause of inflammation nasal mucosa. It also form non-infectious associated with an immunoglobulin E (IgE)-mediated immune response against allergens. Previous studies have indicated that interleukin-1β (IL-1β) has a pathological role in development allergic asthma. The present study was designed to assess whether IL-1β participates pathogenesis AR. A total 45 patients AR were enrolled and identified increased expression expressed by peripheral blood...
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Abstract Mucosa‐associated lymphoid tissue lymphoma translocation protein‐1 (MALT1) protease presents crucial antiapoptotic properties in activated B cell‐like diffuse large B‐cell (ABC‐DLBCL); however, the mechanism is unclear. Here, we reported that inhibition of MALT1 ABC‐DLBCL cells led to cell apoptosis, along with elevated mitochondrial reactive oxygen species production and a reduced consumption rate. These alterations induced by were associated expression glutaminase (GLS1)...
SARS-CoV-2, a highly contagious coronavirus, is responsible for the global pandemic of COVID-19 in 2019. Currently, it remains uncertain whether SARS-CoV-2 possesses oncogenic or oncolytic potential influencing tumor progression. Therefore, important to evaluate clinical and functional role on Here, we integrated bioinformatic analysis RNA-seq data from GEO database performed studies explore regulatory solid progression, including lung, colon, kidney liver cancer. Our results demonstrate...
Zika virus (ZIKV), belonging to the Flaviviridae family, has been a severe threat human health since worldwide outbreak. ZIKV is capable of inducing fetal microcephaly, Guillain-Barre syndrome, and other serious neurological complications. Polypyrimidine tract-binding protein 1 (PTBP1) key member heterogeneous nuclear ribonucleoproteins (hnRNPs) functioning in selective mRNA splicing gene expression regulation. Our previous study indicated that PTBP1 increases astrocytes upon infection, yet...
Abstract Excessive inflammatory responses induced upon SARS-CoV-2 infection interlocks with severe symptoms and acute lung injury in patients Severe Coronavirus Disease 2019 (COVID-19). Revealing the mechanism underlying control of SARS-CoV-2-triggered immune-inflammatory would help us to understand pathological process guide clinical treatment. However, effect NLRP3 inflammasome on regulating SARS-CoV-2-induced has not been reported. Here, we revealed a distinct by which nucleocapsid (N)...