A5102905862- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Skin Diseases and Diabetes
- Muscle Physiology and Disorders
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Advanced Biosensing Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Immunodeficiency and Autoimmune Disorders
- Innovative Microfluidic and Catalytic Techniques Innovation
- Biosensors and Analytical Detection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Inflammatory mediators and NSAID effects
- Salivary Gland Disorders and Functions
- T-cell and B-cell Immunology
- Osteoarthritis Treatment and Mechanisms
- Parkinson's Disease and Spinal Disorders
- Rheumatoid Arthritis Research and Therapies
- Diabetes and associated disorders
- Celiac Disease Research and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hereditary Neurological Disorders
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
China-Japan Friendship Hospital
2014-2024
Peking Union Medical College Hospital
2012-2022
Academy of Medical Sciences
2022
State Grid Corporation of China (China)
2022
Peking University People's Hospital
2021
Peking University
2021
Inner Mongolia Electric Power (China)
2019
SFC Fluidics (United States)
2013-2017
X-Fab (Germany)
2015
Cancer is a significant complication contributing to increased mortality in idiopathic inflammatory myopathies (IIMs), and the association between IIMs cancer has been extensively reported. Myositis-specific autoantibodies (MSAs) can help stratify patients into more homogeneous groups may be used as biomarker for cancer-associated myositis. In this study, we aimed systematically define MSAs IIMs. Serum from 627 with was tested MSAs. The risk different estimated by standardized incidence...
The abnormal formation and insufficient clearance of neutrophil extracellular traps (NETs) has been reported to be involved in the pathogenesis lupus nephritis (LN). regulation NETs may contribute increases levels circulating cell-free DNA (cfDNA). present study tested hypothesis that elevated plasma cfDNA are related LN.Fifty-four systemic erythematosus (SLE) patients 43 control subjects were included this study. concentrations measured using Picogreen Kit, low-density granulocyte (LDG)...
This phase 2b, randomised, double-blind, placebo-controlled trial evaluated the efficacy and safety of telitacicept, a novel fusion protein that neutralises signals B lymphocyte stimulator proliferation-inducing ligand, in active systemic lupus erythematosus (SLE).
Efficacy of adalimumab for ankylosing spondylitis (AS) has been established Western populations but not in the Chinese population. This study is first to evaluate efficacy and safety patients with AS.Chinese adults active AS who had an inadequate response or were intolerant ≥1 non-steroidal anti-inflammatory drugs randomised 40 mg (N=229) matching placebo (N=115) subcutaneously every other week (EOW) 12 weeks, followed by a 12-week open-label EOW phase. The primary endpoint was percentage...
The epidemiological characteristics of Sjögren syndrome (SS) are significantly varied in different countries. We conducted the present study to survey primary SS China. recruited 483 patients from 16 Chinese medical centers nationwide January 2009 November 2011 and assessed salivary lacrimal gland dysfunction, organ involvement, autoimmunity these patients. cohort included 456 women 27 men (ratio, 17:1; mean age at onset, 42 ± 11 years; median diagnosis, 49 range, 41–56 years). Male showed a...
Anti-Mi-2 antibody is a type of myositis-specific autoantibody found in idiopathic inflammatory myopathy patients. To investigate the clinical features and long-term outcomes anti-Mi-2-positive dermatomyositis (DM) Serum anti-Mi-2β antibodies were detected 357 DM patients by enzyme-linked immunosorbent assays, possible associated investigated based on cross-sectional longitudinal studies. Of patients, 40/357 (11.2%) positive for to have significantly higher frequency V sign (72.5% vs 45.7%;...
Objective. To investigate early cardiac involvement in patients with polymyositis/dermatomyositis (PM/DM), and to evaluate the risk factors for impairment. Methods. The study population included 46 PM/DM who did not have overt cardiovascular manifestations 21 age- sex-matched healthy controls. Traditional echocardiography tissue Doppler imaging (TDI) were used function both groups. Clinical characteristics recorded. Multivariate logistics regression analysis was applied impairment PM/DM....
Objective. To investigate the levels of soluble programmed death ligand 1 (sPD-L1) and evaluate its association with malignancy in patients dermatomyositis (DM). Methods. Levels sPD-L1 were measured serum from 88 DM without malignancies (sDM), 40 cancer-related (CRDM), 30 healthy controls (HC) using ELISA. The CRDM subjects divided into new-onset cancers (nCRDM) stable (sCRDM). Receiver-operating characteristic (ROC) curve analysis was performed to determine cutoff value that distinguished...
Dermatomyositis (DM) associated rapidly progressive interstitial lung disease (RP-ILD) has high mortality rate and poor prognosis. Galectin-9 (Gal-9) plays multiple functions in immune regulation. We investigated Gal-9 expression DM patients its association with DM-ILD. A total of 154 idiopathic inflammatory myopathy 30 healthy controls were enrolled the study. Cross-sectional longitudinal studies used to analyze between serum levels clinical features. Enzyme-linked immunosorbent assay...
Abstract Background Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by the presence of numerous autoantibodies. The interaction infectious agents (viruses, bacteria and parasites) genetically susceptible host may be key mechanism for SLE. Toxoplasma gondii widespread intracellular parasite that has been implicated in pathogenesis diseases. However, relationship between T. infection increased risk SLE Chinese populations remains unclear. Methods...