A5008380199- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Skin Diseases and Diabetes
- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Peripheral Neuropathies and Disorders
- Viral Infections and Immunology Research
- Celiac Disease Research and Management
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Genetic factors in colorectal cancer
- Dermatology and Skin Diseases
- Neuroendocrine Tumor Research Advances
- Sarcoidosis and Beryllium Toxicity Research
- Neurogenetic and Muscular Disorders Research
- Myofascial pain diagnosis and treatment
- Leprosy Research and Treatment
- Blood groups and transfusion
- Dermatological and Skeletal Disorders
- Parkinson's Disease and Spinal Disorders
- Pancreatitis Pathology and Treatment
- Spondyloarthritis Studies and Treatments
- IgG4-Related and Inflammatory Diseases
- Salivary Gland Tumors Diagnosis and Treatment
China-Japan Friendship Hospital
2015-2025
Peking Union Medical College Hospital
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
This study aimed to analyze the clinical features of anti-SAE antibodies in Chinese myositis patients comparison with different cohorts. The were tested and control subjects. Long-term follow-up was conducted on antibody-positive patients. Anti-SAE exclusively present 12 out 394 (3.0%) adult dermatomyositis (DM) Of anti-SAE-positive DM patients, 75% had distinctive diffuse dark-red or pigment-like skin rashes, 67% these experienced mild muscle weakness. Muscular biopsies showed pathological...
Rheumatoid arthritis (RA) is a common chronic, inflammatory autoimmune disease, and early clinical diagnosis crucial for its treatment. CXCR4 expression was characterized in arthritic mouse models joints of RA patients, [18 F]AIF-NOTA-QHA-04 specificity assessed non-malignant cells with elevated expression. This study explored the application CXCR4-targeted PET probe monitoring disease activity therapeutic efficacy RA. To this aim, metabolic characteristics correlation uptake severity were...
The objective of this study was to detect the prevalence anti-3-hydroxyl-3- methylglutaryl coenzyme A reductase (anti-HMGCR) antibodies in Chinese patients with idiopathic inflammatory myopathies (IIMs), and analyze clinical features antibody-positive IIM patients.The presence anti-HMGCR detected 405 IIMs, 90 healthy controls, 221 other rheumatic diseases by using an ELISA kit. Clinical data from -negative were compared. Long-term follow-up conducted evaluate role antibody disease...
To evaluate the efficacy and safety of Janus kinase inhibitors (JAKi) in treatment refractory anti-synthetase syndrome (ASS) real-world clinical settings. The medical records all ASS patients who were treated with JAKi from October 2020 to June 2023 retrospectively reviewed. Twenty included, (100%) had interstitial lung disease (ILD). After JAKi, 14 (70%) showed significant improvement manifestations, including arthritis (56.3% vs. 6.3%, p = 0.002), rash (77.8% 27.8%, 0.012), shortness...
To identify potential risk factors and prognostic of Pneumocystis jirovecii pneumonia (PJP) infection in anti-melanoma differentiation-associated gene 5 antibody-positive DM (anti-MDA5+ DM) patients, to evaluate the diagnostic performance metagenomic next-generation sequencing (mNGS).Anti-MDA5+ patients who underwent mNGS or real-time PCR for PJP detection were recruited. The occurrence death analysed via Logistic regression Cox proportional hazards regression, respectively. efficacy was...
Abstract Objectives The purpose was to clarify the characteristics of interstitial lung disease (ILD) in immune-mediated necrotizing myopathy (IMNM) patients with anti-signal recognition particle (SRP) antibodies. Methods Medical records IMNM anti-SRP antibodies were reviewed retrospectively. Results A total 60 identified. Twenty-seven (45.0%) diagnosed ILD based on imaging: nonspecific pneumonia (NSIP) 17 (63.0%) and organizing 9 (33.3%). Reticulation pattern identified whereas 10 cases...
Objective: To investigate the prevalence, risk factors and prognosis of invasive pulmonary aspergillosis (IPA) in patients with anti-melanoma differentiation-associated gene 5 positive dermatomyositis (anti-MDA5+ DM). Methods: A retrospective analysis was conducted anti-MDA5+ DM diagnosed between January 2016 March 2023. Patients lower respiratory tract specimens were categorized into IPA+ IPA- groups based on presence IPA their clinical characteristics prognoses then compared. Results: Of...
Objective: To investigate the clinical features and prognosis of anti-melanoma differentiation-related gene 5 (MDA5) antibody anti-cyclic citrullinated peptide (CCP) double-positive dermatomyositis (DM) (MDA5+/CCP+ DM). Methods: A retrospective analysis 264 consecutive cases MDA5+ DM hospitalized from March 2018 to 2022, patients with anti-CCP antibodies were screened out. Patients MDA5+/CCP- served as control. Propensity score matching was used compare features, well treatment survival...
To investigate the clinical features, severity and prognosis of interstitial lung disease (ILD) in patients with mixed connective tissue (MCTD).
Objective This study aimed to analyze the clinical features of anti-PM/Scl antibodies in Chinese patients. Method We reviewed data antibody-positive patients, including their long-term follow-up. Results A total 30 patients carried antibodies, 21 (70%) were females, and mean age was 55.4 years, 15 (50%) 10 (33.3%) positive for anti-PM/Scl-75 anti-PM/Scl-100, respectively. Fifteen cases diagnosed as inflammatory myopathy, namely, 11 dermatomyositis (DM) 4 polymyositis (PM). Five (16.7%) with...
Abstract Objective To investigate the role of bronchoalveolar lavage (BAL) in DM-associated interstitial lung disease (ILD). Methods We retrospectively reviewed medical records patients with DM-ILD who underwent bronchoscopy between October 2015 and September 2019. then collated clinical features, laboratory data findings. The follow-up study was terminated on 1 May 2020. Results A total 113 were included this study, including 27 acute/subacute pneumonia (A/SIP) 86 chronic (CIP). A/SIP group...
Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive dermatomyositis (DM) has low survival rate, whereas macrophage activation syndrome (MAS) is a severe and life-threatening associated with autoimmune diseases. Their coexistence very rare. This study aimed to describe the prevalence, clinical characteristics, outcomes of anti-MDA5 antibodies-positive DM patients complicated MAS.In this retrospective study, we enrolled antibodies, who were hospitalized between 2016...
To explore the clinical features and prognoses of dermatomyositis (DM) associated with a double-positive anti-MDA5 anti-aminoacyl-tRNA synthetase (anti-ARS) antibody presentation. We retrospectively analyzed 1280 consecutive patients idiopathic inflammatory myopathy (IIM). Individuals anti-ARS antibodies (anti-MDA5+/ARS+) were compared to anti-MDA5-/ARS+ anti-MDA5+/ARS- control individuals based on clinical, pulmonary radiological characteristics, treatment, follow-up information. Six...