A5103101594- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Galectins and Cancer Biology
- HIV Research and Treatment
- Salivary Gland Disorders and Functions
- HIV/AIDS drug development and treatment
- Bioinformatics and Genomic Networks
- RNA and protein synthesis mechanisms
- Bipolar Disorder and Treatment
- Genetic Syndromes and Imprinting
- Chromosomal and Genetic Variations
- Bacterial Genetics and Biotechnology
- Radiomics and Machine Learning in Medical Imaging
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Functional Brain Connectivity Studies
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
- Diabetes and associated disorders
- Epigenetics and DNA Methylation
- Genomic variations and chromosomal abnormalities
- Urinary and Genital Oncology Studies
- Cancer-related molecular mechanisms research
- Attention Deficit Hyperactivity Disorder
- Race, Genetics, and Society
Macau University of Science and Technology
2024
Institute of Psychology, Chinese Academy of Sciences
2009-2023
Dongguan People’s Hospital
2010-2023
Southern Medical University
2022-2023
Tianjin University of Science and Technology
2020
University of Chinese Academy of Sciences
2017
Chinese Academy of Sciences
2002-2015
China National Chemical Corporation (China)
2011
Sinopec (China)
2011
University of Lausanne
2007-2009
Understanding why some people establish and maintain effective control of HIV-1 others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using whole-genome association strategy, we identified polymorphisms that explain nearly 15% variation among individuals viral load during asymptomatic set-point period infection. One these found within an endogenous retroviral element associated with major histocompatibility allele human leukocyte antigen ( HLA )– B*5701 , whereas...
To extend the understanding of host genetic determinants HIV-1 control, we performed a genome-wide association study in cohort 2,554 infected Caucasian subjects. The was powered to detect common variants explaining down 1.3% variability viral load at set point. We provide overwhelming confirmation three associations previously reported and show further independent effects both rare Major Histocompatibility Complex region (MHC). also examined polymorphisms previous candidate gene studies fail...
To meet the immediate need for a framework of post-whole genome association (WGA) annotation, we have developed WGAViewer, suite JAVA software tools that provides user-friendly interface to automatically annotate, visualize, and interpret set P -values emerging from WGA study. Most valuably, it can be used highlight possible functional mechanisms in an automatic manner, example, by directly or indirectly implicating polymorphism with apparent link gene expression, help generate hypotheses...
Abstract The root of Aconitum carmichaelii Debx . (Fuzi) is an herbal medicine used in China that exerts significant efficacy rescuing patients from severe diseases. A key toxic compound Fuzi, aconitine (AC), could trigger unpredictable cardiotoxicities with high-individualization, thus hinders safe application Fuzi. In this study we investigated the individual differences AC-induced cardiotoxicities, biomarkers and underlying mechanisms. Diversity Outbred (DO) mice were as a genetically...
Balancing competing objectives remains a fundamental challenge in multi-task learning (MTL), primarily due to conflicting gradients across individual tasks. A common solution relies on computing dynamic gradient update vector that balances tasks as optimization progresses. Building this idea, we propose ConicGrad, principled, scalable, and robust MTL approach formulated constrained problem. Our method introduces an angular constraint dynamically regulate directions, confining them within...
Schizophrenia is a common psychiatric disorder with high heritability and complex genetic architecture. Genome-wide association studies (GWAS) have identified several significant loci associated schizophrenia. However, the explained still low. Growing evidence has shown schizophrenia attributable to multiple genes moderate effects. In-depth mining integration of GWAS data urgently expected uncover disease-related gene combination patterns. Network-based analysis promising strategy better...
We describe a sequence assembler, RePS (repeat-masked Phrap with scaffolding), that explicitly identifies exact 20mer repeats from the shotgun data and removes them prior to assembly. The established software is used compute meaningful error probabilities for each base. Clone-end-pairing information construct scaffolds order orient contigs. show real human rice reasonable assemblies are possible even at coverages of only 4× 6×, despite having up 42.2% in repeats. [The following individuals...
Abstract Background Burkholderia cenocepacia is a threatening nosocomial epidemic pathogen in patients with cystic fibrosis (CF) or compromised immune system. Its high level of antibiotic resistance an increasing concern treatments against its infection. Strain B. J2315 the most infectious isolate from CF patients. There strong demand to reconstruct genome-scale metabolic network systematically analyze capabilities and virulence traits, search for potential clinical therapy targets. Results...
BackgroundAPOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G) has antiretroviral activity associated with the hypermutation of viral DNA through cytosine deamination. APOBEC3G two deaminase (CDA) domains; catalytically inactive amino-terminal domain (N-CDA) carries Vif interaction domain. There is no 3-D structure solved by X-ray or nuclear magnetic resonance.Methodology/Principal FindingsWe predicted human based on crystal APOBEC2. To assess model structure, we...
Objective To evaluate the possibility of copy number variation (CNV) CYP2B6. Methods We investigated CNV in 226 HIV-1-infected individuals by quantitative PCR. Identification a candidate prompted characterization size deletion assessment absence exons, mapping recombination site sequencing, and southern blot. The functional consequences were assessed silico (predicted protein), vivo, evaluation plasma drug levels CYP2B6 substrate efavirenz. Results Analyses identified one white individual...
Primary Sjögren's syndrome (pSS) is a complex autoimmune disorder. So far, genetic research in pSS has lagged far behind and the underlying biological mechanism unclear. Further exploring existing genome-wide association study (GWAS) data urgently expected to uncover disease-related gene combination patterns. Herein, we conducted network-based analysis by integrating GWAS Han Chinese with protein-protein interactions network identify candidate genes. After module detection evaluation, 8...
Abstract Background Recent progress in high-throughput technologies has greatly contributed to the development of DNA methylation profiling. Although there are several reports that describe methylome detection whole genome bisulfite sequencing, high cost and heavy demand on bioinformatics analysis prevents its extensive application. Thus, current strategies for study mammalian methylomes is still based primarily genome-wide methylated enrichment combined with microarray or sequencing....
Background and Aims: Methionine has been proven to inhibit addictive behaviors of cocaine dependence. This study aimed identify the potential mechanisms MET relating its inhibitory effects on induced cellular behavioral changes. Methods: MRNA miRNA high-throughput sequencing prefrontal cortex in a mouse model conditioned place preference (CPP) combined with L-methionine was performed. Differentially expressed miRNAs (DE-miRNAs) differentially genes (DEGs) regulated by inhibited were...
Post-traumatic stress disorder (PTSD) is a psychiatric syndrome that occurs after trauma exposure. Neurotransmitters such as dopamine and oxytocin have been reported to be involved in neuropathology of PTSD. Previous studies indicated the dopamine-oxytocin interaction may contribute behavioral disorders. Thus, exploring epistasis (gene-gene interaction) between oxytocinergic dopaminergic systems might useful reveal genetic basis In this study, we analyzed two functional single nucleotide...
The polymorphism of genes involved in folate-mediated one-carbon metabolism may be a risk factor for neural tube defects (NTDs). In the present study, we aimed to investigate single nucleotide polymorphisms (SNPs) BHMT, CUBN, FTCD, GAMT, GART, SARDH, SHMT1, and MUT, their effect on NTDs Chinese Han population.A total 270 cases 192 controls were enrolled this study. SNPs analyzed with next-generation sequencing method. folate levels brain tissues from 113 available 123...
Objectives: Investigation of the genetic basis endophenotype and analysis pathways with multiple genes small effects might increase understanding attention deficit hyperactivity disorder (ADHD). Here we aimed to explore cognitive flexibility in ADHD at single nucleotide polymorphism (SNP), gene pathway levels.Methods: The trail-making test was used 788 patients. A genome-wide association conducted for 644,166 SNPs.Results: top SNP rs2049161 (P = 5.08e-7) involved DLGAP1 CADPS2 gene-based...