A5102808153- Plant-based Medicinal Research
- Berberine and alkaloids research
- Pharmacogenetics and Drug Metabolism
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Drug Transport and Resistance Mechanisms
- Traditional Chinese Medicine Analysis
- Ferroptosis and cancer prognosis
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Ginger and Zingiberaceae research
- Phytochemistry and Biological Activities
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Immunotherapy and Immune Responses
- Phytochemistry and Bioactive Compounds
- Biochemical effects in animals
- Inflammatory mediators and NSAID effects
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Plant chemical constituents analysis
- vaccines and immunoinformatics approaches
- Liver Diseases and Immunity
- Nephrotoxicity and Medicinal Plants
Guangzhou University of Chinese Medicine
2016-2025
Ministry of Education of the People's Republic of China
2018-2024
Xi'an Shiyou University
2023
University of Missouri
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2015
// Yunli Tong 1, 2, * , Yuting Liu Hongming Zheng 2 Liang Wenqin Jinjun Wu Rilan Ou Guiyu Zhang Fangyuan Li Ming Hu 3 Zhongqiu Linlin Lu 1 School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China International Institute for Translational Chinese Medicine, Guangzhou University 510006, Department Pharmacological and College Pharmacy, Houston, Texas, 77030, USA These authors have contributed equally to this work Correspondence to: Liu, e-mail:...
Lung cancer remains the most common cause of cancer-related deaths, with a high incidence and mortality in both sexes worldwide. Chemoprevention has been effective strategy for lung prevention. Thus, exploring novel candidate agents low toxicity chemoprevention is essential urgent. Houttuynia cordata Thunb. (Saururaceae) (H. cordata), which widely used herbal medicine also popularly consumed as healthy vegetable, exhibits anti-inflammatory, antioxidant antitumor activity. However,...
Hepatic fibrosis (HF) represents the excessive wound healing where an excess amount of connective tissues is formed within liver, finally resulting in cirrhosis or even hepatocellular carcinoma (HCC). Therefore, it significant to discover efficient agents and components treat HF, thus restraining further progression hepatopathy. Astragalus membranaceus (Fisch.) Bunge [also called Astragali Radix (AR)] a famous herb traditional Chinese medicine (TCM), which possesses variety biological...
The Aconitum species, which mainly contain bioactive alkaloids, are frequently administered concomitantly with other herbal medicines or chemical drugs in clinics. potential risk of drug-drug interactions (DDIs) arising from co-administration alkaloids and against specific targets such as P-glycoprotein (P-gp) must be evaluated. This study focused on the effects three representative alkaloids: aconitine (AC), benzoylaconine (BAC), aconine, expression activity P-gp. We observed that increased...
Abstract The root of Aconitum carmichaelii Debx . (Fuzi) is an herbal medicine used in China that exerts significant efficacy rescuing patients from severe diseases. A key toxic compound Fuzi, aconitine (AC), could trigger unpredictable cardiotoxicities with high-individualization, thus hinders safe application Fuzi. In this study we investigated the individual differences AC-induced cardiotoxicities, biomarkers and underlying mechanisms. Diversity Outbred (DO) mice were as a genetically...
Polyphyllin VI (PVI) and polyphyllin VII (PVII) derived from Paris polyphylla possess anti-cancer activities. However, the mechanisms for anti-lung cancer effects of PVI PVII remain poorly understood. In this study, exhibited inhibitory on proliferation A549 NCI-H1299 cells. induced G2/M cell cycle arrest triggered apoptosis. upregulated tumor suppressor protein p53 downregulated cyclin B1. The two treatments significantly increased expression levels death receptor 3, 5, Fas, cleaved PARP,...
Colon cancer is a highly malignant with poor prognosis. Astragalus membranaceus (Fisch.) Bunge (Huang Qi in Chinese, HQ), well-known Chinese herbal medicine and popular food additive, possesses various biological functions has been frequently used for clinical treatment of colon cancer. However, the underlying mechanism not fully understood. Isoflavonoids, including formononetin (FMNT) calycosin (CS), are main bioactive ingredients isolated from HQ. Thus, this study aimed to explore...
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by insulin deficiency due to pancreatic