A5101421793- Lung Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Neurological Disease Mechanisms and Treatments
- Biofuel production and bioconversion
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Head and Neck Cancer Studies
- Healthcare and Venom Research
- Family Support in Illness
- Medicinal Plants and Bioactive Compounds
- Hepatitis B Virus Studies
- Palliative Care and End-of-Life Issues
- Congenital heart defects research
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Mental Health Treatment and Access
- Genomics, phytochemicals, and oxidative stress
- Fatty Acid Research and Health
- RNA modifications and cancer
- Pressure Ulcer Prevention and Management
- Liver Diseases and Immunity
- Coronary Artery Anomalies
- Cardiomyopathy and Myosin Studies
- Biomedical Research and Pathophysiology
- Pancreatitis Pathology and Treatment
Wuhan University
2022-2025
Dalian Medical University
2025
Taizhou People's Hospital
2025
Nantong University
2025
Nanjing Medical University
2025
Harbin Medical University
2025
Renmin Hospital of Wuhan University
2024-2025
Fujian Medical University
2020-2024
Hubei Provincial Center for Disease Control and Prevention
2024
Guangzhou University of Chinese Medicine
2023
Abstract Objective Demoralization has garnered increasing attention in recent years as a significant psychological distress. This study aims to identify latent classes of demoralization lung cancer patients using Latent Class Analysis (LCA) from person‐centered perspective and explore the factors influencing demoralization. Methods A cross‐sectional convenience sampling was conducted among 567 three tertiary hospitals China. LCA employed classify heterogeneous Multinomial logistic regression...
Despite the recent advancements in treatment of cancer, 5-year survival patients with non-small cell lung cancer (NSCLC) remains unsatisfactory. Lung adenocarcinoma (LUAD) is NSCLC's most common subtype, and metastasis major cause death cancer. Therefore, identifying novel targets associated NSCLC crucial to improving treatment. This study aimed characterize expression GNGT1 LUAD clarify mechanism underlying association between higher level worse prognosis patients. The transcriptome...
ABSTRACT Glioblastoma multiforme (GBM) is the deadliest brain tumour with an extremely poor prognosis. Tryptophan catabolism could enhance array of protumour‐genic signals and promoted progression in GBM. However, mechanisms oncogenic signalling under tryptophan potential therapy targeting this pathway have not been completely understood. Interleukin 4‐induced 1 (IL4I1) newly defined as a metabolic enzyme function GBM cells still remains unclear. In our study, we found IL4I1 was upregulated...
Abstract The most common socioeconomic healthcare issues in clinical are burns, surgical incisions and other skin injuries. Skin lesion healing can be achieved with nanomedicines drug application techniques. This study developed a nano-spray based on cross-linked amorphous calcium peroxide (CaO2) nanoparticles of polyacrylic acid (PAA) for treating wounds (PAA-CaO2 nanoparticles). CaO2 serves as ‘drug’ precursor, steadily continuously releasing ions (Ca2+) hydrogen (H2O2) under mildly acidic...
Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it effective against cerebral ischemic/reperfusion (I/R) injury. The pharmacologically active component and targeting site of remain elusive. In this study, the cerebral-protective effect evaluated on a rat transient middle artery occlusion (MCAO) model. data showed oral administration had better effectiveness in protection than an intravenous injection. Neither nor its metabolite...
Cholestasis is a common complication of hepatitis B virus (HBV) infection, characterized by increased intrahepatic and plasma bile acid levels. was found negatively associated with outcome, however, the exact mechanism which cholestasis impacts anti-viral immunity impedes HBV clearance remains elusive. Here, we that cholestatic mice are featured dysfunctional T cells response, as indicated decreased sub-population CD25+ /CD69+ CD4+ CD8+ cells, while CTLA-4+ subsets were increased....
Abstract Mutations in cysteine and glycine-rich protein 3 (CSRP3)/muscle LIM (MLP), a key regulator of striated muscle function, have been linked to hypertrophic cardiomyopathy (HCM) dilated (DCM) patients. However, the roles CSRP3 heart development regeneration are not completely understood. In this study, we characterized novel zebrafish gene-trap line, gSAIzGFFM218A , which harbors an insertion csrp3 genomic locus, heterozygous fish served as expression reporter line homozygous mutant...
In this article, an ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry method was developed to detect the chemical structures of proanthocyanidins (PAs) from seed coats Schisandra chinensis. The cleavage pathways compounds were revealed. S. chinensis PAs, including two monomers, B-type procyanidin dimers, three trimers, one mixed trimer and tetramer, confirmed. These nine detected in for first time. identified by comparing their maximum absorption...
Cystine is the primary source material for synthesis of glutathione. However, pharmacokinetics and tissue distribution cystine are largely unknown. A surrogate analyte D4-cystine was employed to generate calibration curves determination levels endogenous in mice by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Validation assessments proved sensitivity, specificity reproducibility method with a lower limit quantification (LLOQ) 5 ng/mL over 5-5000 plasma. The were evaluated after...
The excessive accumulation of lipids in hepatocytes induces a type cytotoxicity called hepatic lipotoxicity, which is fundamental contributor to liver metabolic diseases (such as NAFLD). Magnesium isoglycyrrhizinate (MGIG), magnesium salt the stereoisomer natural glycyrrhizic acid, widely used safe and effective protectant. However, mechanism by MGIG protects against NAFLD remains unknown. Based on significant correlation between reprogramming metabolism, we aimed explore beneficial effects...
Understanding the particular mechanisms by which vulnerability and capability factors influence cognitive reactivity (CR) can contribute to an enhanced capacity adequately react depression. However, few studies have explored CR model. The main aim of present study was develop a model that specifies predictive effects for depression among individuals at high risk first-episode recurrent A national cross-sectional, online using convenience sampling conducted 587 vulnerable healthy 224...
<title>Abstract</title> Lipid metabolism reprogramming is critical in various biological processes and considered a hallmark cancers. The expression data of mRNA corresponding follow-up information were obtained from TCGA used as training set the CGGA validating set. Based on genes involved lipid metabolism, 550 glioma samples clustered by unsupervised classification method. Then, we construct metabolism-related risk signature based Lasso regression algorithm. mechanism related to score was...
Motivation: The staging and prognosis of nasopharyngeal carcinoma (NPC) remain significant challenges, with potential correlations to the Ki-67 proliferation status. Goal(s): To assess analyze an ITH model based on pre-treatment synthetic MRI (SyMRI) for predicting status in patients pathologically confirmed NPC. Approach: Twenty-eight NPC who underwent SyMRI. SyMRI data were processed generate T1, T2, PD maps. ITHscore, derived from quantitative parameter maps, was utilized establish models...