A5100660182- Periodontal Regeneration and Treatments
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Ubiquitin and proteasome pathways
- Synthesis of Organic Compounds
- Natural product bioactivities and synthesis
- Endodontics and Root Canal Treatments
- Tissue Engineering and Regenerative Medicine
- Adipose Tissue and Metabolism
- T-cell and Retrovirus Studies
- dental development and anomalies
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Retinoids in leukemia and cellular processes
- Inflammatory mediators and NSAID effects
- Bone and Dental Protein Studies
- Garlic and Onion Studies
- Flavonoids in Medical Research
- Berberine and alkaloids research
- Cell death mechanisms and regulation
- Synthesis and bioactivity of alkaloids
- Natural Products and Biological Research
- Dental Trauma and Treatments
- Electrospun Nanofibers in Biomedical Applications
Guangzhou University of Chinese Medicine
2010-2024
Soochow University
2020
China Medical University
2010-2020
Affiliated Hospital of Southwest Medical University
2020
Shanghai Medical College of Fudan University
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Fudan University
2020
Nanjing Normal University
2020
Lianyungang Maternal and Children’s Hospital
2019
State Key Laboratory of Oncology in South China
2017
Abstract Depression is a significant global health concern that remains inadequately treated due to the limited effectiveness of conventional drug therapies. One potential therapeutic agent, hypericin (HYP), identified as an effective natural antidepressant. However, its poor water solubility, low bioavailability, and ability penetrate brain parenchyma have hindered clinical application. To address these shortcomings enhance efficacy HYP, it loaded onto black phosphorus nanosheets (BP)...
BACKGROUND Accumulating evidence suggests that plant-derived molecules may prove extremely beneficial in the development of chemotherapy for deadly cancer types. Multiple myeloma is a rare and incurable type cancers. Very little research has been directed towards management multiple myeloma. Here, anticancer effects triterpenoid, Asiaticoside, were examined against drug-resistant cell line KM3/BTZ. MATERIAL AND METHODS Cell viability was determined by CCK-8 assay autophagy checked...
Abstract Lung cancer is the leading cause of cancer-associated mortality worldwide. DNA damage-regulated autophagy modulator 1 (DRAM1) plays an important roles in and tumor progression. However, mechanisms by which DRAM1 inhibits growth are not fully understood. Here, we report that was decreased nonsmall-cell lung carcinoma (NSCLC) associated with poor prognosis. We confirmed inhibited growth, migration, invasion NSCLC cells vitro. Furthermore, overexpression suppressed xenografted tumors...
Atherosclerosis is characterized by endothelial dysfunction, lipid deposition, fibro-proliferative reactions and inflammation. Octacosanol a high-molecular-weight primary aliphatic alcohol. As the main component of cholesterol-lowering drug, octacosanol could inhibit lipids accumulation cholesterol metabolism. To explore indication on protection, we evaluated its effects proliferation migration human umbilical vein cells (HUVEC). Cell viability assay using methyl thiazolyl tetrazolium...
AbstractObjective To investigate the relationship between Tiam1 and lymphangiogenesis in human colorectal carcinoma (CRC) tissues, as well expression of VEGF-C a CRC cell line (HCT116) after knockdown gene with RNA interference (RNAi). Methods The expressions Tiam1, Rac1, Podoplanin 50 samples were detected by immunohistochemical analysis. lymph microvessel density (LMVD) positive specimens was evaluated. results analyzed statistically to correlation VEGF-C, node metastasis other...
Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease in preterm infants, which characterized by alveolar and vascular increased permeability. Hyperoxia critical factor the pathogenesis of BPD, hyperoxia-induced acute injury (HALI) model has similar pathological manifestations as human therefore, may provide insight into BPD. Studies have shown that Twist1 regulates pulmonary permeability LPS-induced through Ang-Tie2 pathway. However, effect pathway on HALI not been...
Abstract Continuing our studies on NO‐donating ursolic acid–benzylidene derivatives as potential antitumor agents, we designed and synthesized a series of new arylidene containing acid aromatic heterocyclic units. Compounds 5c 6c showed significant broad‐spectrum activity. Compound exhibited nearly three‐ to nine‐fold higher cytotoxicity compared with the parent drug in A549, MCF‐7, HepG‐2, HT‐29, HeLa cells, it was also found be most potent apoptosis inducer MCF‐7 cells. More importantly,...
FNC, 2'-deoxy-2'-β-fluoro-4'-azidocytidine, is a novel cytidine analogue, that has shown strong antiproliferative activity in human lymphoma, lung adenocarcinoma and acute myeloid leukemia. In this study, we investigated the effects of FNC on mantle cell lymphoma (MCL) underlying mechanisms. vitro experiments, viability was detected by CCK8 assay, cycle progression apoptosis were assessed flow cytometry, expression relative proteins Western Blot. The vivo antitumor effect SCID xenograft...
Arenobufagin (ARE) has demonstrated potent anticancer activity in various types of tumor, but the role and mechanism ARE for lung cancer remain unclear. Oxidative stress exists under normal conditions is an inevitable state body. A variety noxious stimuli can break equilibrium oxidative promote apoptosis. Here, we used a CCK-8 assay to examine cell viability. We determined damage by measuring levels intracellular ROS GSH, SOD, MDA. Annexin V-FITC/PI double staining assay, as well Hoechst...
Intraocular pressure (IOP) generates stress and strains in the laminar cribrosa sclera, which may affect development progression of glaucoma. Scleral stiffness material components have changed under elevated IOP. However, detailed components' changes hypertensive sclera are not well understood. In this study, we aimed to investigate main scleral extracellular matrix (ECM) metalloproteinase 2 (MMP2), their relationship with time chronic IOP Sprague-Dawley rats. Ocular hypertension model was...
Inhibition of the glycolytic pathway is a critical strategy in anticancer therapy because role aerobic glycolysis cancer cells. The inhibitor 2-Deoxy-d-glucose (2-DG) has shown potential combination with other agents. Buforin IIb an effective antimicrobial peptide (AMP) broad-spectrum activity and selectivity. efficacy treatment 2-DG buforin prostate remains unknown. Here, we tested as mitochondria-targeting AMP androgen-independent human cell line DU145. Combining had synergistic toxic...
Objective: 15-Deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ ) induces reactive oxygen species (ROS)-mediated apoptosis in many malignant cells, which has not been studied hepatoma cells. In this study, we investigated whether 15d-PGJ induced hepatocellular carcinoma (HCC) associated with ROS. Materials and methods: The LM3, SMMC-7721, Huh-7 HCC cell lines were treated (5–40 µM) for 24, 48, 72 hours. Cholecystokinin 8 was used to detect the cytotoxicity of . Flow cytometry, Hoechst staining,...
To evaluate the effects of basic fibroblast growth factor (FGF-2) and vascular endothelial (VEGF) on proliferation, migration, adhesion human periodontal ligament stem cells (PDLSC) in vitro.Human PDLSC were cultured vitro using tissue culture method.The incubated with various concentrations FGF-2 VEGF [A:α-MEM 2% fetal bovine serum (FBS) (control 1); B:A supplemented 20 µg/L FGF-2; C:A 10 VEGF; D:A E:α-MEM 10% FBS 2); F:E G:E H:E VEGF]. Soluble tetrazolium salts assay was used to...
Introduction This study was undertaken to examine the anticancer effects of natural product rhein on human leukaemia cells. Material and methods Cell viability determined by MTT assay. Immunofluorescence staining, DAPI, AO/EB, annexin V/PI staining were used for detection apoptosis. qRT-PCR analysis protein expression. Western blot determine Results The results revealed that caused a significant (p < 0.05) dose-dependent decrease in AML-193 It also morphological changes such as cell...
Purpose: To investigate the effect of pyrimidine-thioindole on gastric cancer proliferation and underlying mechanism action. Methods: Cell viability apoptosis were determined using MTT assay Annexin V/PI assay, respectively. Reverse transcription-polymerase chain reaction (RT-PCR) was used for determination expression levels miR-145, while protein assayed by western blotting. Results: Pyrimidine-thioindole treatment significantly inhibited AGS SNU-5 cells (p < 0.05), but had no GES-1 cells....
The aim of this study was to investigate the effect TIEG1 on K562 cell apoptosis and expression BCL-2/BAX, PTEN. different concentration(0, 1, 5, 10, 20 ng/ml) were used treat cells, growth inhibition rate detected by using MTT method. After treating cells with 10.00 ng/ml TIEG1, flow cytometry. RT-PCR levels BCL-2 /BAX results showed that displays inhibitory proliferation in time-and dose-dependent manner (r = 0.52, P < 0.05) ; after treated for 6, 12, 24 48 h, IC50 48.19, 18.72, 9.5 3.85...