A5101585174- Neonatal Respiratory Health Research
- Autophagy in Disease and Therapy
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Mitochondrial Function and Pathology
- Maternal Mental Health During Pregnancy and Postpartum
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- COVID-19 and healthcare impacts
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sepsis Diagnosis and Treatment
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Neuroscience of respiration and sleep
- Cancer Research and Treatments
- Schizophrenia research and treatment
- COVID-19 Impact on Reproduction
- Cancer, Hypoxia, and Metabolism
- Endodontics and Root Canal Treatments
- Liver Disease and Transplantation
- Fibroblast Growth Factor Research
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
First Affiliated Hospital Zhejiang University
2024-2025
Qingdao University
2018-2025
Xinjiang Medical University
2024-2025
Tumor Hospital of Xinjiang Medical University
2024-2025
Zhejiang University
2025
Wuxi Taihu Hospital
2024
Nanjing University of Chinese Medicine
2022-2024
Affiliated Hospital of Southwest Medical University
2017-2024
Hainan Medical College Hospital
2024
Hainan General Hospital
2024
The aim is to diagnose COVID-19 earlier and improve its treatment by applying medical technology, the "COVID-19 Intelligent Diagnosis Treatment Assistant Program (nCapp)" based on Internet of Things. Terminal eight functions can be implemented in real-time online communication with "cloud" through page selection key. According existing data, questionnaires, check results, diagnosis automatically generated as confirmed, suspected, or suspicious 2019 novel coronavirus (2019-nCoV) infection. It...
Abstract FGF-10 can prevent or reduce lung specific inflammation due to traumatic infectious injury. However, the exact mechanisms are poorly characterized. Additionally, effect of on lung-resident mesenchymal stem cells (LR-MSCs) has not been studied. To better characterize LR-MSCs, was intratracheally delivered into lungs rats. Three days after instillation, bronchoalveolar lavage performed and plastic-adherent were cultured, characterized then therapeutically rats LPS intratracheal...
Leptomeningeal metastasis (LM) is the most devastating complication of non-small cell lung cancer (NSCLC), and its incidence increasing. We investigated survival outcomes patients with NSCLC who received combined antiangiogenic systemic therapies before after LM progression explored survival-associated factors. Patients epidermal growth factor receptor (EGFR)-mutant or wild-type NSCLC-LM receiving therapy were included. Survival analyzed separately for different progression. The primary...
This study aims to uncover the mechanisms and quantitative dose response relationships among sleep quality, anxiety, depression miscarriage, as well develop a comprehensive predictive model for miscarriage rate. In this study, 1058 pregnant women in mainland China were recruited. We utilized both univariate, multivariate analyses sensitivity analysis investigate relationship between depression, miscarriage. Then, we used mediation directed acyclic graph explore how anxiety quality mediate...
Background: Bronchopulmonary dysplasia (BPD) is one of the most common long-term lung complications prematurely born infants caused by prolonged injury and repair during immature development. Resveratrol has reported to exert anti-inflammatory, antioxidation, antiapoptosis effects. This study aimed investigate effect resveratrol in BPD.Methods: Neonate rats were delivered spontaneously randomized divided into four groups on postnatal day (PN) 0.5: room air (21% O2)+dimethyl sulfoxide (DMSO),...
Bronchopulmonary dysplasia is a severe and long-term pulmonary disease in premature infants. Hyperoxia-induced acute lung injury plays critical role bronchopulmonary dysplasia. Resveratrol polyphenolic phytoalexin natural agonist of Sirtuin 1. Many studies have shown that resveratrol has protective effect on hyperoxia-induced damage, but its specific mechanism still not clear. Further exploration the possible was main goal this study. In study, human alveolar epithelial cells were used to...
Meteorin‑β (Metrnβ) is a protein that secreted by skeletal muscle and adipose tissue, participates in cardiovascular diseases. However, its role myocardial infarction (MI) has not been fully elucidated to date. The aim of the present study was investigate underlying mechanism Metrnβ MI. In study, mice were subjected left coronary ligation induce MI model before being injected with adeno‑associated virus 9 (AAV9)‑Metrnβ overexpress Metrnβ. Mice echocardiography pressure‑volume measurements 2...
Abstract Preservation or restoration of normal alveolar epithelial barrier function is crucial for pulmonary oedema resolution. Keratinocyte growth factor‐2 ( KGF ‐2), a potent cell mitogen, may have role in preventing ventilator‐induced lung injury VILI ), which occurs frequently mechanically ventilated patients. The aim the study was to test ‐2 rats. Forty healthy adult male S prague‐ D awley rats were randomly allocated into four groups, where Groups HVZP (high‐volume zero positive...
Chronic composite psychological stress intervention is the accumulation of factors which may induce stress, including food deprivation, water deprivation and swimming in cold water. Approximately 40% cases atherosclerosis are associated with chronic stress. The aim present study was to explore effects Lycium barbarum polysaccharides (LBP) on blood lipid levels oxidative hyperlipidemic mice, following A mouse model generated, mice were subjected treated LBP for 30 days. After days...
Biomaterials could affect the inflammation reaction and wound healing via activation polarization of macrophages. However, influence iRoot SP mineral trioxide aggregate (MTA) on macrophage under inflammatory conditions was not reported although these two root filling materials have been applied extensively in patients undergoing endodontic treatment. Therefore, present study aimed to explore mechanism how MTA cell behavior RAW 264.7 macrophages when stimulated by lipopolysaccharide (LPS)...
Iron overload has been found in the lungs of patients with idiopathic pulmonary fibrosis (IPF) and is thought to be involved disease progression; however, underlying mechanism complex not yet fully understood. We sought assess vitro role iron progression lung epithelial cells, examine possible regulation IPF.Erastin was used establish a cell model accumulation mouse line 12 (MLE-12). A Cell Counting Kit-8 assay annexin V staining were applied measure viability apoptosis, quantitative...
Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease in preterm infants, which characterized by alveolar and vascular increased permeability. Hyperoxia critical factor the pathogenesis of BPD, hyperoxia-induced acute injury (HALI) model has similar pathological manifestations as human therefore, may provide insight into BPD. Studies have shown that Twist1 regulates pulmonary permeability LPS-induced through Ang-Tie2 pathway. However, effect pathway on HALI not been...
Objectives Our previous study showed that resveratrol (Res) attenuates apoptosis and mitochondrial dysfunction in alveolar epithelial cell injury induced by hyperoxia activating the SIRT1/PGC-1α signaling pathway. In present study, we investigated whether Res protects against hyperoxia-induced lung neonatal rats Methods Naturally delivered were randomly divided into six groups: normoxia + normal saline, dimethyl sulfoxide (DMSO), Res, DMSO, Res. Lung tissue samples collected on postnatal...
Colorectal cancer (CRC) is a heterogeneous cancer. Its treatment depends on its anatomical site and molecular features. Carcinomas of the rectosigmoid junction are frequent; however, specific data these tumors sparse, as they frequently assigned to either colon or rectum. This study sought identify features determine whether there should be any difference between therapeutic management that sigmoid rectum cancer.The 96 CRC patients with carcinomas in colon, junction, were retrospectively...
Vitamin D (1,25-(OH)2D) has been reported to be associated with hyperuricemia in many epidemiologic reports. CYP24A1 is a rate-limiting enzyme involved vitamin metabolism. The aim of this study was investigate the association between rs6068816 polymorphism gene and hyperuricemia. 130 patients from First Affiliated Hospital Zhengzhou University were included as case group. subjects without selected control group establish 1:1 matching case-control study. Logistic regression used Additionally,...
Abstract HCC cell immune escape is a critical element in the evolution of malignancy. Herein, regulatory mechanism lncRNA NEAT1 regulating was investigated. Exosomes were isolated from M2 TAMs using ExoQuick‐TC. Then, cells incubated with TAMs‐derived exosomes (M2‐exos). The activation perforin + CD8 T measured flow cytometry. secretion IFN‐γ assessed ELISA. Cell viability and migration detected CCK8 Transwell assays, respectively. RIP RNA pull‐down assays used to investigate link between...
Modulation of inflammation is a crucial component the development acute lung injury. A20, ubiquitin editing enzyme, may regulate cellular inflammatory reactions, particularly those involving signaling pathway nuclear factor NF-κB (NF‑κB). The present study investigated mechanism by which A20 downregulated NF‑κB and further contributed to macrophage polarization from M1 M2 phenotypes in lipopolysaccharide (LPS)‑induced Sprague‑Dawley rats injected with LPS were used study. Bronchoalveolar...